Dose-response function of persistent pollutants: Difference between revisions
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== | ==Question== | ||
'''Dose-response function of persistent pollutants''' describes the cancer dose-responses of several pollutants in humans (lifetime risk due to lifetime exposure). | '''Dose-response function of persistent pollutants''' describes the cancer dose-responses of several pollutants in humans (lifetime risk due to lifetime exposure). | ||
== | ==Answer== | ||
{{resultlink}} | |||
{| {{prettytable}} | {| {{prettytable}} | ||
| | | | ||
| | |Dose-response slope | ||
|----- | |----- | ||
|Dieldrin | |Dieldrin | ||
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|} | |} | ||
== | ==Rationale== | ||
===Data=== | |||
Potency of pollutants. Cancer slope factors (CSF) are used for cancer and Reference Dose (RfD) values are used for non-cancer endpoints. The data comes from the U.S.EPA. <ref> U.S.EPA. Guidance for Assessing Chemical Contaminant Data for Use in Fish Advisory. Volume 2: Risk Assessment and Fish Consumption Limits, 3rd Edition. 2000. Table 3-1. [http://www.epa.gov/waterscience/fish/guidance.html Open access Internet file] [http://ytoswww/yhteiset/Huippuyksikko/Kirjallisuus/Fish_and_health/EPAFishAdvisory/ Intranet file]</ref> | |||
The response assessment is restricted to cancer endpoints, because it is the more sensitive endpoint. | |||
Table. Cancer slope factors (CSF) for several pollutants. | |||
{| {{prettytable}} | {| {{prettytable}} | ||
| | | | ||
| | |CSF | ||
|----- | |----- | ||
|Dieldrin | |Dieldrin | ||
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|---- | |---- | ||
|} | |} | ||
===Causality=== | |||
Upstream variables | |||
* None | |||
===Unit=== | |||
(mg/kg/d)<sup>-1</sup> | |||
===Formula=== | |||
CSFs are directly used. | |||
==See also== | ==See also== |
Latest revision as of 08:13, 13 October 2012
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Question
Dose-response function of persistent pollutants describes the cancer dose-responses of several pollutants in humans (lifetime risk due to lifetime exposure).
Answer
{{#opasnet_base_link:Op_en1906}}
Dose-response slope | |
Dieldrin | 16 |
Toxaphene | 1.1 |
Dioxin | 1.56E+005 |
PCB | 2 |
Rationale
Data
Potency of pollutants. Cancer slope factors (CSF) are used for cancer and Reference Dose (RfD) values are used for non-cancer endpoints. The data comes from the U.S.EPA. [1]
The response assessment is restricted to cancer endpoints, because it is the more sensitive endpoint.
Table. Cancer slope factors (CSF) for several pollutants.
CSF | |
Dieldrin | 16 |
Toxaphene | 1.1 |
Dioxin | 1.56E+005 |
PCB | 2 |
Causality
Upstream variables
- None
Unit
(mg/kg/d)-1
Formula
CSFs are directly used.
See also
References
- ↑ U.S.EPA. Guidance for Assessing Chemical Contaminant Data for Use in Fish Advisory. Volume 2: Risk Assessment and Fish Consumption Limits, 3rd Edition. 2000. Table 3-1. Open access Internet file Intranet file