Dose-response function of persistent pollutants: Difference between revisions

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==Scope==
==Question==


'''Dose-response function of persistent pollutants''' describes the cancer dose-responses of several pollutants in humans (lifetime risk due to lifetime exposure).  
'''Dose-response function of persistent pollutants''' describes the cancer dose-responses of several pollutants in humans (lifetime risk due to lifetime exposure).  


==Definition==
==Answer==


===Data===
{{resultlink}}
 
Potency of pollutants. Cancer slope factors (CSF) are used for cancer and Reference Dose (RfD) values are used for non-cancer endpoints. The data comes from the U.S.EPA. <ref> U.S.EPA. Guidance for Assessing Chemical Contaminant Data for Use in Fish Advisory. Volume 2: Risk Assessment and Fish Consumption Limits, 3rd Edition. 2000. Table 3-1. [http://www.epa.gov/waterscience/fish/guidance.html Open access Internet file] [http://ytoswww/yhteiset/Huippuyksikko/Kirjallisuus/Fish_and_health/EPAFishAdvisory/ Intranet file]</ref>
 
The response assessment is restricted to cancer endpoints, because it is the more sensitive endpoint.
 
Table. Cancer slope factors (CSF) for several pollutants.


{| {{prettytable}}
{| {{prettytable}}
|
|
|CSF
|Dose-response slope
|-----
|-----
|Dieldrin
|Dieldrin
Line 35: Line 29:
|}
|}


===Causality===
==Rationale==


Upstream variables
===Data===
* None


===Unit===
Potency of pollutants. Cancer slope factors (CSF) are used for cancer and Reference Dose (RfD) values are used for non-cancer endpoints. The data comes from the U.S.EPA. <ref> U.S.EPA. Guidance for Assessing Chemical Contaminant Data for Use in Fish Advisory. Volume 2: Risk Assessment and Fish Consumption Limits, 3rd Edition. 2000. Table 3-1. [http://www.epa.gov/waterscience/fish/guidance.html Open access Internet file] [http://ytoswww/yhteiset/Huippuyksikko/Kirjallisuus/Fish_and_health/EPAFishAdvisory/ Intranet file]</ref>


(mg/kg/d)<sup>-1</sup>
The response assessment is restricted to cancer endpoints, because it is the more sensitive endpoint.


===Formula===
Table. Cancer slope factors (CSF) for several pollutants.
 
CSFs are directly used.
 
==Result==
 
{{resultlink}}


{| {{prettytable}}
{| {{prettytable}}
|
|
|Dose-response slope
|CSF
|-----
|-----
|Dieldrin
|Dieldrin
Line 69: Line 56:
|----
|----
|}
|}
===Causality===
Upstream variables
* None
===Unit===
(mg/kg/d)<sup>-1</sup>
===Formula===
CSFs are directly used.


==See also==
==See also==

Latest revision as of 08:13, 13 October 2012

Benefit-risk assessment on farmed salmon: To the assessment page | To the Analytica model
Decision variables:

Variable:Recommendation for consumption of farmed salmon | Variable:Pollutant concentration limits for fish feed

Indicators:

Variable:Pollutant health risk due to the consumption of salmon | Variable:Net health effects due to the consumption of salmon

Other variables:

Variable:Persistent pollutant concentrations in fish feed | Variable:Persistent pollutant concentrations in salmon | Variable:Salmon intake in the population of the Western Europe | Variable:Exposure to persistent pollutants due to salmon in the population of the Western Europe | Variable:Dose-response function of persistent pollutants | Variable:Omega-3 content in salmon | Variable:Omega-3 intake due to salmon in the population of the Western Europe | Variable:Dose-response function of cardiovascular effects of omega-3 fatty acids | Variable:Total mortality in the Western Europe | Variable:Cardiovascular mortality in the Western Europe | Variable:Cardiovascular effects of omega-3 in salmon in the Western Europe


Question

Dose-response function of persistent pollutants describes the cancer dose-responses of several pollutants in humans (lifetime risk due to lifetime exposure).

Answer

{{#opasnet_base_link:Op_en1906}}


Dose-response slope
Dieldrin 16
Toxaphene 1.1
Dioxin 1.56E+005
PCB 2

Rationale

Data

Potency of pollutants. Cancer slope factors (CSF) are used for cancer and Reference Dose (RfD) values are used for non-cancer endpoints. The data comes from the U.S.EPA. [1]

The response assessment is restricted to cancer endpoints, because it is the more sensitive endpoint.

Table. Cancer slope factors (CSF) for several pollutants.

CSF
Dieldrin 16
Toxaphene 1.1
Dioxin 1.56E+005
PCB 2

Causality

Upstream variables

  • None

Unit

(mg/kg/d)-1

Formula

CSFs are directly used.

See also

References

  1. ↑ U.S.EPA. Guidance for Assessing Chemical Contaminant Data for Use in Fish Advisory. Volume 2: Risk Assessment and Fish Consumption Limits, 3rd Edition. 2000. Table 3-1. Open access Internet file Intranet file
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