Dose-response function of persistent pollutants: Difference between revisions

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{{Farmed salmon assessment}}
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[[Category:Exposure-response functions]]
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==Scope==
==Scope==
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==Result==
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Revision as of 13:06, 4 September 2008

Benefit-risk assessment on farmed salmon: To the assessment page | To the Analytica model
Decision variables:

Variable:Recommendation for consumption of farmed salmon | Variable:Pollutant concentration limits for fish feed

Indicators:

Variable:Pollutant health risk due to the consumption of salmon | Variable:Net health effects due to the consumption of salmon

Other variables:

Variable:Persistent pollutant concentrations in fish feed | Variable:Persistent pollutant concentrations in salmon | Variable:Salmon intake in the population of the Western Europe | Variable:Exposure to persistent pollutants due to salmon in the population of the Western Europe | Variable:Dose-response function of persistent pollutants | Variable:Omega-3 content in salmon | Variable:Omega-3 intake due to salmon in the population of the Western Europe | Variable:Dose-response function of cardiovascular effects of omega-3 fatty acids | Variable:Total mortality in the Western Europe | Variable:Cardiovascular mortality in the Western Europe | Variable:Cardiovascular effects of omega-3 in salmon in the Western Europe


Scope

Dose-response function of persistent pollutants describes the cancer dose-responses of several pollutants in humans (lifetime risk due to lifetime exposure).

Definition

Data

Potency of pollutants. Cancer slope factors (CSF) are used for cancer and Reference Dose (RfD) values are used for non-cancer endpoints. The data comes from the U.S.EPA. [1]

The response assessment is restricted to cancer endpoints, because it is the more sensitive endpoint.

Table. Cancer slope factors (CSF) for several pollutants.

CSF
Dieldrin 16
Toxaphene 1.1
Dioxin 1.56E+005
PCB 2

Causality

Upstream variables

  • None

Unit

(mg/kg/d)-1

Formula

CSFs are directly used.

Result

{{#opasnet_base_link:Op_en1906}}


Dose-response slope
Dieldrin 16
Toxaphene 1.1
Dioxin 1.56E+005
PCB 2


References

  1. ↑ U.S.EPA. Guidance for Assessing Chemical Contaminant Data for Use in Fish Advisory. Volume 2: Risk Assessment and Fish Consumption Limits, 3rd Edition. 2000. Table 3-1. Open access Internet file Intranet file
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