Case burden of waterborne microbes
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Question
What are the case burdens (in DALYs) of waterborne microbes? Case burden is the disease burden that is caused by one case of infection of a particular microbe. Infection may be latent or symptomatic, and it may or may not lead to more severe complications or even death.
Answer
Rationale
Data
The case burdens are presented as DALYs per case of illness.
Obs  Exposure_agent  Response  Subgroup  Result  Description 

1  giardia  gastroenteritis  Age:04  0.002425  
2  giardia  gastroenteritis  Age:59  0.002732  
3  giardia  gastroenteritis  Age:1014  0.004313  
4  giardia  gastroenteritis  Age:1564  0.002572  
5  giardia  gastroenteritis  Age:6579  0.006245  
6  giardia  gastroenteritis  Age:80+  0.006245  
7  cryptosporidium  gastroenteritis  Age:04  0.001216  
8  cryptosporidium  gastroenteritis  Age:59  0.001989  
9  cryptosporidium  gastroenteritis  Age:1014  0.002877  
10  cryptosporidium  gastroenteritis  Age:1564  0.000818  
11  cryptosporidium  gastroenteritis  Age:6579  0.001174  
12  cryptosporidium  gastroenteritis  Age:80+  0.001174  
13  cryptosporidium  death  Age:04  79.6  probability of death of cryptosporidium infection 9.95E07 in 04yearolds 
14  cryptosporidium  death  Age:59  74.7  probability of death of cryptosporidium infection 0 in 514yearolds 
15  cryptosporidium  death  Age:1014  69.7  probability of death of cryptosporidium infection 0 in 514yearolds 
16  cryptosporidium  death  Age:1564  43.3  probability of death of cryptosporidium infection 2.09E05 in 1564yearolds 
17  cryptosporidium  death  Age:6579  14.8  probability of death of cryptosporidium infection 0.00164 in 6581yearolds 
18  cryptosporidium  death  Age:80+  4.5  probability of death of cryptosporidium infection 0.00164 in 6581yearolds 
19  norovirus  gastroenteritis  Age:04  0.000988  
20  norovirus  gastroenteritis  Age:59  0.000753  
21  norovirus  gastroenteritis  Age:1014  0.000797  
22  norovirus  gastroenteritis  Age:1564  0.000786  
23  norovirus  gastroenteritis  Age:6581  0.000737  
24  norovirus  gastroenteritis  Age:80+  0.000737  
25  norovirus  death  Age:04  79.6  probability of death from norovirus 2.94E06 in 04yearolds 
26  norovirus  death  Age:59  74.7  probability of death from norovirus 0 in 565yearolds 
27  norovirus  death  Age:1014  69.7  probability of death from norovirus 0 in 565yearolds 
28  norovirus  death  Age:1564  43.3  probability of death from norovirus 0 in 565yearolds 
29  norovirus  death  Age:6579  14.8  probability of death from norovirus 0.00024 in 6681yearolds 
30  norovirus  death  Age:80+  4.8  probability of death from norovirus 0.00024 in 6681yearolds 
31  rotavirus  gastroenteritis  Age:04  0.002130  
32  rotavirus  gastroenteritis  Age:59  0.001218  
33  rotavirus  gastroenteritis  Age:1014  0.001281  
34  rotavirus  gastroenteritis  Age:1564  0.000970  
35  rotavirus  gastroenteritis  Age:6579  0.001276  
36  rotavirus  gastroenteritis  Age:80+  0.001276  
37  rotavirus  death  Age:04  79.6  probability of death from rotavirus is 2.13E05 for 04yearolds 
38  rotavirus  death  Age:59  74.7  probability of death from rotavirus is 0 for people 5 years or older 
39  rotavirus  death  Age:1014  69.7  probability of death from rotavirus is 0 for people 5 years or older 
40  rotavirus  death  Age:1564  43.3  probability of death from rotavirus is 0 for people 5 years or older 
41  rotavirus  death  Age:6579  14.8  probability of death from rotavirus is 0 for people 5 years or older 
42  rotavirus  death  Age:80+  4.8  probability of death from rotavirus is 0 for people 5 years or older 
43  campylobacter  gastroenteritis  0.00295  
44  campylobacter  clinical GuillianBarré syndrome  0.29  
45  campylobacter  residual Guillian Barré syndrome  5.8  
46  campylobacter  reactive arthritis  0.024230  Duration of illness 6 weeks, severity 2.1  
47  campylobacter  death  13.3  If ill, probability of death from gastroenteritis is 0.000392, life lost 13.2 years. If ill, probability of death from GBS is 5.33e6, life lost 18.7 years.  
48  E.coli O157:H7  gastroenteritis  0.00062  Probability of gastroenteritis if ill from E. coli is 0.53, severity 0.067, duration 3.4 days.  
49  E.coli O157:H7  hemorrhagic colitis  0.00599  Probability of HC if ill from E. coli is 0.47, severity 0.39, duration 5.6 days.  
50  E.coli O157:H7  haemolytic uraemic syndrome  0.05351  Probability of HUS if ill from E. coli is 0.01, severity 0.93, duration 21 days.  
51  E.coli O157:H7  end stage renal disease  8.7  
52  E.coli O157:H7  death  13.2  Probability of death from E. coli infection is 0.00027, life lost 13.2 years. Probability of death from HUS is 0.04, life lost 26.2 years. Probability of death from ESRD is 0.0252, life lost 34 years. 
The number of years lost to death are calculated as the average years lost for that age group. The expected life years for each age can be found here. The data used is from 20012005.
Treatment  Age  Probability of needing the treatment if ill  Duration (days)  Severity 

untreated  04  0.9375  10  0.067 
untreated  59  0.91034  10  0.067 
untreated  1014  0.72642  10  0.067 
untreated  1564  0.92486  10  0.067 
untreated  6581  0.5365  10  0.067 
general practitioner  04  0.0609  10  0.393 
general practitioner  59  0.0852  10  0.393 
general practitioner  1014  0.272  10  0.393 
general practitioner  1564  0.0721  10  0.393 
general practitioner  6581  0.451  10  0.393 
hospitalised  04  0.0015  30  0.393 
hospitalised  59  0.00446  30  0.393 
hospitalised  1014  0.00158  30  0.393 
hospitalised  1564  0.00304  30  0.393 
hospitalised  6581  0.0125  30  0.393 
Data for Cryptosporidium used in the calculations. The probability of illness if infected is 0.71.
Treatment  Age  Probability of needing the treatment if ill  Duration (days)  Severity 

untreated  04  0.91757  3.5  0.067 
untreated  59  0.80937  3.5  0.067 
untreated  1014  0.68105  3.5  0.067 
untreated  1564  0.97742  3.5  0.067 
untreated  6581  0.94706  3.5  0.067 
general practitioner  04  0.082  7  0.393 
general practitioner  59  0.188  7  0.393 
general practitioner  1014  0.316  7  0.393 
general practitioner  1564  0.0209  7  0.393 
general practitioner  6581  0.0367  7  0.393 
hospitalised  04  0.00043  18.4  0.393 
hospitalised  59  0.00263  18.4  0.393 
hospitalised  1014  0.0029  18.4  0.393 
hospitalised  1564  0.00166  18.4  0.393 
hospitalised  6581  0.0146  18.4  0.393 
Data for norovirus used in the calculations. The probability of illness if infected is 0.7.
Treatment  Age  Probability of needing the treatment if ill  Duration (days)  Severity 

untreated  04  0.94877  3.8  0.067 
untreated  59  0.9902  3.8  0.067 
untreated  1014  0.98239  3.8  0.067 
untreated  1565  0.98434  3.8  0.067 
untreated  6681  0.992741  3.8  0.067 
general practitioner  04  0.0448  5.73  0.393 
general practitioner  59  0.0086  5.73  0.393 
general practitioner  1014  0.0154  5.73  0.393 
general practitioner  1565  0.0137  5.73  0.393 
general practitioner  6681  0.00617  5.73  0.393 
hospitalized  04  0.00643  7.23  0.393 
hospitalized  59  0.0012  7.23  0.393 
hospitalized  1014  0.00221  7.23  0.393 
hospitalized  1565  0.00196  7.23  0.393 
hospitalized  6681  0.00089  7.23  0.393 
The data for rotavirus used in the calculations. The probability of illness if infected is 0.9.
Treatment  Age  Probability of needing the treatment if ill  Duration (days)  Severity 

untreated  04  0.82  4.9  0.067 
untreated  514  0.95  4.9  0.067 
untreated  1564  0.99  4.9  0.067 
untreated  6581  0.97  4.9  0.067 
general practitioner  04  0.137  7.1  0.393 
general practitioner  59  0.0244  7.1  0.393 
general practitioner  1114  0.0511  7.1  0.393 
general practitioner  1564  0.0127  7.1  0.393 
general practitioner  6581  0.0299  7.1  0.393 
hospitalized  04  0.0416  7.7  0.393 
hospitalized  59  0.0213  7.7  0.393 
hospitalized  1081  0  7.7  0.393 
The data for gastroenteritis cases caused by a campylobacter infection used in the calculations. The probability of illness if infected is 0.33, and the probability of the illness being gastroenteritis is 0.98.arg8024: . I assume it's 0.98, since the probability of arthritis is 0.02 and the the probability of gbs is 0.0002. Heta (talk) 13:31, 3 July 2019 (UTC) (type: truth; paradigms: science: comment)
Treatment  Probability of needing the treatment if ill  Duration (days)  Severity 

untreated  0.7627  5.1  0.067 
general practitioner  0.2373  8.4  0.393 
hospitalized  0.0097  14.2  0.393 
Calculations
See also
 Vesiopas (in Finnish)
 Water guide