Developmental dose-responses of fish consumption

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Original author: Henna Karvonen, Foodfiles Ltd 2006.

The effects of fish in development and infancy.

Ecological, descriptive and cross-sectional studies Cohort and case-control studies Exposure data from cohort and case-control studies Interventions Exposure data from interventions Comments
IQ of children - + Fish ++ Fish oil and MeHg Recent meta-analyses have calculated that increasing maternal docosahexaenoic acid (DHA) intake by 100 mg/day increases child IQ by 0.13 points whereas prenatal MeHg exposure sufficient to increase the concentration of mercury in maternal hair at parturition by 1 microg/g decreases IQ by 0.7 points. Cohort study on child development outcomes and prenatal exposures to MeHg from maternal consumption of a diet high in fish found no consistent pattern of associations between these variable.
Prevention of pre-eclampsia - + Omega-3 fatty acids in erythroscytes ++ Fish oil Current evidence does not support the use of fish oil supplements for the prevention of preeclampsia
Prevention of pregnancy induced hypertension ? ? ++ Fish oil At least six trials have examined the effect of fish oil supplementation on pregnancy induced hypertension none of them has provided evidence to support the use of fish oil supplements for the prevention of pregnancy induced hypertension
Retinal function ? ? ++ Long chain PUFA The effect of long chain PUFA supplementation of formula on visual acuity of infants born at term has been studied in at least seven RCTs. No constant findings on benefits exists, but supplementation appears to be relatively safe. Maternal supplementation increases the DHA concentration of milk in lactating mothers.

- No data, + Initial findings, ++ Replicate studies, +++ Plenty of data, ? No profound search done, some data may exist


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