ERF of indoor dampness on respiratory health effects

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Question

What is the association between exposure to indoor dampness and mould in homes and respiratory health effects?

Answer

Exposure-response function

ERF of indoor dampness on respiratory health effects(OR per yes/no visible dampness and/or mold or mold odor)

Obs	Disease	Response metric	Subjects	Exposure route	Exposure metric	Exposure unit	ERF parameter	Threshold	ERF	Description
1	Respiratory health effect	Upper respiratory tract symptoms	All	Inhalation	visible dampness and/or mold or mold odor	yes/no	OR	0	1.70	1.70 (1.44-2.00), No. studies: 13
2	Respiratory health effect	Cough	All	Inhalation	visible dampness and/or mold or mold odor	yes/no	OR	0	1.67	1.67 (1.49-1.86), No. studies: 18
3	Respiratory health effect	Cough	Adults	Inhalation	visible dampness and/or mold or mold odor	yes/no	OR	0	1.52	1.52 (1.18-1.96), No. studies: 6
4	Respiratory health effect	Cough	Children	Inhalation	visible dampness and/or mold or mold odor	yes/no	OR	0	1.75	1.75 (1.56-1.96), No. studies: 6
5	Respiratory health effect	Wheeze	All	Inhalation	visible dampness and/or mold or mold odor	yes/no	OR	0	1.50	1.50 (1.38-1.64), No. studies: 22
6	Respiratory health effect	Wheeze	Adults	Inhalation	visible dampness and/or mold or mold odor	yes/no	OR	0	1.39	1.39 (1.04-1.85), No. studies: 5
7	Respiratory health effect	Wheeze	Children	Inhalation	visible dampness and/or mold or mold odor	yes/no	OR	0	1.53	1.53 (1.39-1.68), No. studies: 17
8	Respiratory health effect	Current asthma	All	Inhalation	visible dampness and/or mold or mold odor	yes/no	OR	0	1.56	1.56 (1.30-1.86), No. studies: 10
9	Respiratory health effect	Ever-diagnosed asthma	All	Inhalation	visible dampness and/or mold or mold odor	yes/no	OR	0	1.37	1.37 (1.23-1.53), No. studies: 8
10	Respiratory health effect	Ever-diagnosed asthma	Children	Inhalation	visible dampness and/or mold or mold odor	yes/no	OR	0	1.35	1.35 (1.20-1.51), No. studies: -
11	Respiratory health effect	Asthma development	All	Inhalation	visible dampness and/or mold or mold odor	yes/no	OR	0	1.34	1.34 (0.86-2.10), No. studies: 4
12	Respiratory health effect	Bronchitis	All	Inhalation	visible dampness and/or mold or mold odor	yes/no	OR	0	1.45	1.45 (1.32-1.59), No. studies: -
13	Respiratory health effect	Bronchitis	Children	Inhalation	visible dampness and/or mold or mold odor	yes/no	OR	0	1.38	1.38 (1.28-1.47), No. studies: -
14	Respiratory health effect	Respiratory infections	All	Inhalation	visible dampness and/or mold or mold odor	yes/no	OR	0	1.44	1.44 (1.31-1.59), No. studies: -
15	Respiratory health effect	Respiratory infections	Adults	Inhalation	visible dampness and/or mold or mold odor	yes/no	OR	0	1.49	1.49 (1.14-1.95), No. studies: -
16	Respiratory health effect	Respiratory infections	Children	Inhalation	visible dampness and/or mold or mold odor	yes/no	OR	0	1.48	1.48 (1.33-1.65), No. studies: -
17	Respiratory health effect	Sensitivity to inhaled antigens	Children	Inhalation	visible dampness and/or mold or mold odor	yes/no	OR	0	1.33	1.33 (1.23-1.44), No. studies: -
18	Respiratory health effect	Hay fever	Children	Inhalation	visible dampness and/or mold or mold odor	yes/no	OR	0	1.35	1.35 (1.18-1.53), No. studies: -

Page-specific entries (indices that have exactly one value each for the whole variable; usually mentioned in the title and/or in the scope.):

• Pollutant: visible dampness and/or mold or mold odor
• Threshold: 0
• Exposure metric: yes/no
• Exposure route: Inhalation

----#: . You can leave the columns listed above out of the table, because all rows have the same value. If you do, then you MUST put the respective information to Category:Exposure-response functions. --Jouni 17:38, 23 January 2012 (EET) (type: truth; paradigms: science: comment)

⇤--#: . If possible, "Disease" should be something that has an ICT-10 code (in this case, the information that is in column "Response metric". In contrast, "Response metric" should describe how the disease was measured: number of cases, incidence, prevalence,... --Jouni 17:38, 23 January 2012 (EET) (type: truth; paradigms: science: attack)

Rationale

Data

Odds ratios for different health effects in homes with vs. without visible dampness and/or mold or mold odor.

Outcome	Subjects	No. studies	Odds ratio central estimate (95 % CI)	Estimated % increase in damp homes
Upper respiratory tract symptoms	All	13	1.70 (1.44–2.00)	52
Cough	All	18	1.67 (1.49–1.86)	50
	Adults	6	1.52 (1.18–1.96)	–
	Children	12	1.75 (1.56–1.96)	–
Wheeze	All	22	1.50 (1.38–1.64)	44
	Adults	5	1.39 (1.04–1.85)	–
	Children	17	1.53 (1.39–1.68)	–
Current asthma	All	10	1.56 (1.30–1.86)	50
Ever-diagnosed asthma	All	8	1.37 (1.23–1.53)	33
	Children		1.35 (1.20–1.51)
Asthma development	All	4	1.34 (0.86–2.10)	30
Bronchitis	All		1.45 (1.32–1.59)
	Children		1.38 (1.28–1.47)
Respiratory infections	All		1.44 (1.31–1.59)
	Adults		1.49 (1.14–1.95)
	Children		1.48 (1.33–1.65)
Sensitivity to inhaled antigens	Children		1.33 (1.23–1.44)
Hay fever	Children		1.35 (1.18–1.53)

Unit

OR per yes/no visible dampness and/or mold or mold odor

Formula

• Generates random samples of possible ORs.
  • Normal distribution assumed, sd estimated from confidence interval using sd = (upper bound - lower bound)/3.92

n <- 10000
erf <- rnorm(n, 1.56, (1.86-1.30)/3.92)
dim(erf) <- c(n, 1, 1)
dimnames(erf) <- list(obs=1:n, Outcome="Current asthma", "Age"="All")
erf <- as.data.frame(as.table(erf))

Result

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See also

• heande:Moisture damage
• Assessment of building policies' effect on dampness and asthma in Europe

Related files

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