Benefit-risk assessment of fish consumption for Beneris: Difference between revisions

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[[heande:Benefit-risk analysis of fish]]
[[category:assessments]]
[[category:fish]]
{{assessment|moderator = Olli
| reference = {{publication
| authors        = Patrycja Gradowska, Jouni T. Tuomisto, Anna Karjalainen, Olli Leino, Päivi Meriläinen
| page          = Benefit-risk assessment of fish consumption for Beneris
| explanation    =
| publishingyear = 2010
| urn            =
| elsewhere      =
}}
}}
[[Image:Uninet BBN 30102007 pg zoomed in.PNG|thumb|400px]]


== Scope ==


==Scope==
Net health effects of fish consumption due to intake of beneficial nutrients and constituents and on the other hand, exposure to environmental contaminants taken up by fish. {{disclink|Decision options/scenarios}}


=== Boundaries  ===


Draft cause-effects diagrams
*''' Environmental contaminants''' relevant from the human health point of view and thus included in the assessment are:
**polychlorinated dibenzo-''p''-dioxins and dibenzofurans (PCDD/F),
**polychlorinated biphenyls (PCB),
**mercury as methyl mercury (MeHg),


===Purpose===


Net health effects of fish consumption due to intake of beneficial nutrients and constituents and on the other hand, exposure to environmental contaminants taken up by fish.
*'''Nutritional constituents''' relevant from the human health point of view include a wide variety of effects and can be viewed from [[Benefit-risk assessment of fish and related policy options|Benefit-risk assessment of fish and related policy options]] under title "Health consequences attributable to fish consumption". However, readily usable beneficial constituents with quantitative dose-response information available included in the assessment are:
**omega-3 polyunsaturated fatty acids (PUFA): EPA and DHA,
===Boundaries===
**iodine (I),


*Environmental contaminants relevant from the human health point of view and thus included in the assessment are:
**PCDD/Fs
**PCBs
**Hg (as MetHg)
*Nutritional constituents relevant from the human health point of view include many and can be viewed here. However, readily usable beneficial constituents with quantitative dose-response information available included in the asessment at the moment are:
**fish oils
**omega-3 PUFAs (omega-3 polyunsaturated fatty acids)
*European subpopulations included in the assessment:
**Finland
**Ireland
**Spain
**Denmark
* Current situation (BAU)


===Scenarios===


BAU-type assessment (business-as-usual assessment), i.e. a burden-of-disease assessment with only one decision scenario.
*'''Health effects''' of fish consumption used in the assessment encompass neurological effects during early development, developmental dental defects, cardiovascular disease and cancer. In particular, the following health effects are considered:


*the effect of prenatal exposure to MeHg and omega-3 fatty acids on childhood cognitive development (IQ),
*the effect of exposure to dioxins and PCBs during early childhood on developmental dental defects (defects of enamel in permanent teeth or missing of smaller molars),
*the effect of exposure to MeHg and omega-3 fatty acids in adulthood on cardiovascular disease,
*the effect of exposure to dioxins and PCBs on cancer.


===Intended users===


Experts, researchers and decision makers in the field of environmental health, anyone interested and concerned with beneficial and hazardous constituents in fish species in the markets.
*'''Beneris population''' - the Beneris population is defined as the general population (all age groups) in
**Finland,
===Participants ===
**Ireland,
**Spain,
**Denmark.
 
Current assessment is performed based on Finnish conditions only.
 
 
*'''Current situation (BAU)'''
 
 
 
=== Scenarios  ===
 
BAU-type assessment (business-as-usual assessment), i.e. a burden-of-disease assessment with only one decision scenario. {{disclink|Decision options/scenarios}}
 
=== Intended users  ===
 
Experts, researchers and decision makers in the field of environmental health, anyone interested and concerned with beneficial and hazardous constituents in fish species in the markets.  
 
=== Participants ===


Participation basically completely open. Some parts containing original data will be protected.  
Participation basically completely open. Some parts containing original data will be protected.  
*Everyone interested
 
*Everyone interested  
*Beneris researchers (full access to the protected parts)
*Beneris researchers (full access to the protected parts)


==Definition==
== Definition ==


{{kaavio tähän}}
[[Image:Uninet BBN 30102007 pg zoomed in.PNG|thumb|400px|center]]


===Decision variables===
=== Variables  ===


* None at the moment
*Decision variables: None at the moment {{disclink|Decision options/scenarios}}
*Indicators: See health effect variables in the table below
*Other variables: See table


===Indicators===
* [[Variable:Risk for dental aberrations in children|Variable:Risk for dental aberrations in children]]
* [[Myocardial infarction risk in adults in Beneris|Myocardial infarction risk in adults in Beneris]]
* [[Total cancer risk in adults in Beneris|Total cancer risk in adults in Beneris]]
* [[Intelligence quotient (IQ) in children in Beneris|Intelligence quotient (IQ) in children in Beneris]]


*[[Variable:]]
---
* [http://heande.opasnet.org/wiki/Cancer_dose-responses_of_fish_consumption?rdfrom=http%3A%2F%2Fen.opasnet.org%2Fen-opwiki%2Findex.php%3Ftitle%3DNugget%3ACancer_dose-responses_of_fish_consumption%26redirect%3Dno Cancer dose responses]
* [http://heande.opasnet.org/wiki/Cardiovascular_dose-responses_of_fish_consumption?rdfrom=http%3A%2F%2Fen.opasnet.org%2Fen-opwiki%2Findex.php%3Ftitle%3DNugget%3ACardiovascular_dose-responses_of_fish_consumption%26redirect%3Dno Cardiovascular dose responses]
* [http://heande.opasnet.org/wiki/Mental_health_dose-responses_of_fish_consumption?rdfrom=http%3A%2F%2Fen.opasnet.org%2Fen-opwiki%2Findex.php%3Ftitle%3DNugget%3AMental_health_dose-responses_of_fish_consumption%26redirect%3Dno Mental health dose-responses]
* [http://heande.opasnet.org/wiki/Developmental_dose-responses_of_fish_consumption?rdfrom=http%3A%2F%2Fen.opasnet.org%2Fen-opwiki%2Findex.php%3Ftitle%3DNugget%3ADevelopmental_dose-responses_of_fish_consumption%26redirect%3Dno Developmental dose-responses]
* [http://heande.opasnet.org/wiki/All-cause_mortality_dose-response_of_fish_consumption?rdfrom=http%3A%2F%2Fen.opasnet.org%2Fen-opwiki%2Findex.php%3Ftitle%3DNugget%3AAll-cause_mortality_dose-response_of_fish_consumption%26redirect%3Dno All-cause mortality dose-responses]
* [http://en.opasnet.org/w/Variable:Cancer_risk_in_adults Total cancer risks in adults]
* [http://heande.opasnet.org/wiki/Domestic_fish_consumption_of_the_pregnant_women_in_Finland Fish consumption in Finland, pregnant women]
* [http://en.opasnet.org/w/Variable:Concn._of_beneficial_nutrients_in_various_fish_species Nutrients in fish species]
* [http://en.opasnet.org/w/Variable:Exposure-response_of_MeHg_intake_for_IQ_change_in_children Exposure-response of MeHg intake vs. IQ change in children]
* [http://en.opasnet.org/w/Variable:Exposure-response_of_MeHg_intake_for_MI_risk_in_adults Exposure-response of MeHg intake for MI risk]
* [http://en.opasnet.org/w/Variable:Exposure-response_of_PCB_intake_for_cancer_risk_in_adults Exposure-response of PCB intake for cancer risk]
* [http://heande.opasnet.org/wiki/Variable:Exposure-response_functions_for_tooth_defects_caused_by_TCDD_(children)?rdfrom=http%3A%2F%2Fen.opasnet.org%2Fen-opwiki%2Findex.php%3Ftitle%3DVariable%3AExposure-response_functions_for_tooth_defects_caused_by_TCDD_%28children%29%26redirect%3Dno Exposure-response of TCDD intake for teeth defects]
* [http://en.opasnet.org/w/Variable:Exposure-response_of_PCB_intake_for_dental_aberrations_risk_in_children Exposure-response of PCB intake for dental aberrations in children]
* [http://heande.opasnet.org/wiki/ERF_of_dioxin_on_dental_aberrations Exposure-response of dioxin for dental aberrations]
* [http://heande.opasnet.org/wiki/Variable:General_exposure-response_function_for_tooth_defects_caused_by_TCDD?rdfrom=http%3A%2F%2Fen.opasnet.org%2Fen-opwiki%2Findex.php%3Ftitle%3DVariable%3AGeneral_exposure-response_function_for_tooth_defects_caused_by_TCDD%26redirect%3Dno Generalized exposure-response for teeth defects caused by TCDD]
* [http://en.opasnet.org/w/Variable:Intake_of_PCBs_from_fish PCB intake from fish]
* [http://en.opasnet.org/w/Variable:Intake_of_PCDD/Fs_from_fish PCDD/F intake from fish]
* [http://en.opasnet.org/w/Variable:Omega-3-fatty_acid_concn.in_various_fish_species Omega-3 fatty acid concentration is fish species]
* [


===Other variables===


*[[Variable:]]
*[[Variable:]]
*[[Variable:]]
*[[Variable:Body weight]]
*[[Variable:]]
*[[Variable:]]
*[[Variable:]]
===Indices===


{| {{prettytable}}
{| {{prettytable}}
!Age categorizations
|-
|-----
! Population characteristics
|
| [[Body weight in Finland|Body weight in Finland]] &#124;  [[Height in Finland]] &#124;  [[Baseline intelligence quotient (IQ) score in children|Baseline intelligence quotient (IQ) score in children]]  &#124;  [[Baseline risk of dental aberrations]] | [[Mortality in Finland]]<span style="text-decoration: underline;"></span>
*0 to 2 years
|-
*2 to 6 years
! Environmental variables
*6 to 18 years
| [[Concentrations of beneficial nutrients in fish|Concentrations of beneficial nutrients in fish]] &#124; [[Mercury and methyl mercury concentrations in fish|Mercury and methyl mercury concentrations in fish]] &#124; [[Concentrations of PCDD/Fs in fish|Concentrations of PCDD/Fs in fish]] &#124; [[Concentrations of PCBs in fish|Concentrations of PCBs in fish]]
*18-65 years
|-
! Exposure variables
| [[Fish oil intake in Beneris|Fish oil intake in Beneris]] &#124; [[Methyl mercury intake from fish in Beneris|Methyl mercury intake from fish in Beneris]] &#124; [[Iodine intake from fish in Beneris|Iodine intake from fish in Beneris]] &#124; [[Intake of PCB from fish in Beneris|Intake of PCB from fish in Beneris]] &#124; [[Intake of PCDD/F from fish in Beneris|Intake of PCDD/F from fish in Beneris]] &#124; [[Domestic fish consumption of the general population in Finland|Domestic fish consumption of the general population in Finland]] &#124; [[Domestic fish consumption of the pregnant women in Finland|Domestic fish consumption of the pregnant women in Finland]] &#124;
|-
! Exposure-response functions
| [[ERF of omega-3 fatty acids on intelligence quotient|ERF of omega-3 fatty acids on intelligence quotient]] &#124; [[ERF of omega-3 fatty acids on CVD risk in adults|ERF of omega-3 fatty acids on CVD risk in adults]]<span style="text-decoration: underline;"></span> &#124; [[ERF of methyl mercury on intelligence quotient|ERF of methyl mercury on intelligence quotient]] &#124; [[ERF of methyl mercury on myocardial infarction|ERF of methyl mercury on myocardial infarction]] &#124; [[ERF of methyl mercury on CVD risk in adults|ERF of methyl mercury on CVD risk in adults]] &#124; [[Variable:Exposure-response of iodine intake for IQ change in children|Variable:Exposure-response of iodine intake for IQ change in children]] &#124; [[Variable:Exposure-response of PCB intake for dental aberrations risk in children|Variable:Exposure-response of PCB intake for dental aberrations risk in children]] &#124;&nbsp; [[ERF of PCB on cancer|ERF of PCB on cancer]] &#124; [[Variable:Exposure-response of PCDD/F intake for dental aberrations risk in children|Variable:Exposure-response of PCDD/F intake for dental aberrations risk in children]] &#124; [[ERF of dioxin on cancer|ERF of dioxin on cancer]] &#124; [[Variable:Exposure-response of PCDD/F intake for cancer risk in adults|Variable:Exposure-response of PCDD/F intake for cancer risk in adults]] &#124;
|-
! Health effect variables
| [[Risk of dental aberrations in children in Beneris]] &#124; [[Intelligence quotient (IQ) in children in Beneris|Intelligence quotient (IQ) in children in Beneris]] | [[Myocardial infarction risk in adults in Beneris]] | [[Total cancer risk in adults in Beneris]] &#124; [[Net health effects in Beneris]] &#124; <br>
|}
|}


{| {{prettytable}}
{| {{prettytable}}
!Gender categorizations
|-
|-----
| Nutritional benefits and risks of PCDD/F exposure of fish consumption in Finnish children and adults [[Media:Valikaavio_RBA_Fish_PCDDs_A_vs._C_25102007_ak_XML.ANA|Analytica model]]
|
|-
*Men
| [[:beneris:Risk_assessment_of_MeHg_and_n-3_fatty_acids_in_fish|Beneris:Risk assessment of MeHg and n-3 fatty acids in fish]]
*Women
|}
|}
[[Image:Valikaavio RBA Fish PCDDs A vs. C 25102007 ak.PNG|thumb|600px|center]]
=== Indexes  ===


{| {{prettytable}}
{| {{prettytable}}
!Smoking categorizations
|-
|-----
! Fish species
|
|-
*Smokers
|  
*Non-smokers
*Baltic herring (Clupea harengus membras)
*Herring (Clupea harengus)
*Vendace (Coregonus albula)
*Whitefish (Coregonus lavaretus)
*Pike (Esox lucius)
*Rainbow trout (Onchorhynchus mykiss)
*Shrimp (Pandalus sp.)
*Perch (Perca fluviatilis)
*Saithe (Pollachius virens)
*Atlantic salmon (Salmo salar)
*Pike-perch (Sander lucioperca)
*Tuna (Thunnus thynnus)
 
|}
|}


{| {{prettytable}}
{| {{prettytable}}
!Socio-economic status categorizations
|-
|-----
! Nutrients
|
|-
*?
|  
*?
*Omega-3 fatty acids
*?
*Selenium
*Iodine
*Vitamin D
*Vitamin E
*Group B vitamins
 
|}
|}


Age categorizations were chosen in order to describe health effects of fish consumption in infants (0-2 years, this class includes prenatal period as well), adolescent (2-18 years), adults (18-55 years) and elderly people (55-).


{| {{prettytable}}
{| {{prettytable}}
!Fish species, not specified yet
|-
|-----
! Age categories (years)
|
|-
*Farmed_salmon(sea+inland)
|
*Wild_salmon(sea)
*0 - 2
*Herring_(sea)
*2 - 18
*White_fish(sea)
*18 - 55
*Sprat(sea)
*55 -
*Perch(sea)
 
*Flounder(sea)
*Pike-perch(sea)
*Bream(sea)
*Pike(sea)
*Vendace(sea)
*Burbot(sea)
*Wild_salmon(inland)
*White_fish(inland)
*Perch(inland)
*Pike-perch(inland)
*Bream(inland)
*Pike(inland)
*Vendace(inland)
*Burbot(inland)
|}
|}


== Result ==
{{resultlink}}
==See also==


===Analyses ===
* Fish-related assessments:
** [[Benefit-risk assessment of fish consumption for Beneris]]
** [[Benefit-risk assessment of methyl mercury and omega-3 fatty acids in fish]]
** [[Benefit-risk assessment on farmed salmon]]
* [http://en.opasnet.org/en-opwiki/index.php?title=Benefit-risk_assessment_of_fish_and_related_policy_options&oldid=8398 A previous version of this assessment with important background information]




==Result==
;EU funded projects from Cordis database
* [http://cordis.europa.eu/fetch?CALLER=OFFR_O_SOC_EN&ACTION=D&DOC=92&CAT=OFFR&QUERY=012565604f71:38d3:3832eff0&RCN=2348 New methods to ensure food safety]


===Results===
==References==


===Conclusions ===
<references/>
[[Category:Beneris]]
[[Category:THL publications 2010]]

Latest revision as of 09:41, 29 January 2011



Scope

Net health effects of fish consumption due to intake of beneficial nutrients and constituents and on the other hand, exposure to environmental contaminants taken up by fish. D↷

Boundaries

  • Environmental contaminants relevant from the human health point of view and thus included in the assessment are:
    • polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/F),
    • polychlorinated biphenyls (PCB),
    • mercury as methyl mercury (MeHg),


  • Nutritional constituents relevant from the human health point of view include a wide variety of effects and can be viewed from Benefit-risk assessment of fish and related policy options under title "Health consequences attributable to fish consumption". However, readily usable beneficial constituents with quantitative dose-response information available included in the assessment are:
    • omega-3 polyunsaturated fatty acids (PUFA): EPA and DHA,
    • iodine (I),


  • Health effects of fish consumption used in the assessment encompass neurological effects during early development, developmental dental defects, cardiovascular disease and cancer. In particular, the following health effects are considered:
  • the effect of prenatal exposure to MeHg and omega-3 fatty acids on childhood cognitive development (IQ),
  • the effect of exposure to dioxins and PCBs during early childhood on developmental dental defects (defects of enamel in permanent teeth or missing of smaller molars),
  • the effect of exposure to MeHg and omega-3 fatty acids in adulthood on cardiovascular disease,
  • the effect of exposure to dioxins and PCBs on cancer.


  • Beneris population - the Beneris population is defined as the general population (all age groups) in
    • Finland,
    • Ireland,
    • Spain,
    • Denmark.

Current assessment is performed based on Finnish conditions only.


  • Current situation (BAU)


Scenarios

BAU-type assessment (business-as-usual assessment), i.e. a burden-of-disease assessment with only one decision scenario. D↷

Intended users

Experts, researchers and decision makers in the field of environmental health, anyone interested and concerned with beneficial and hazardous constituents in fish species in the markets.

Participants

Participation basically completely open. Some parts containing original data will be protected.

  • Everyone interested
  • Beneris researchers (full access to the protected parts)

Definition

Variables

  • Decision variables: None at the moment D↷
  • Indicators: See health effect variables in the table below
  • Other variables: See table

---


Population characteristics Body weight in Finland | Height in Finland | Baseline intelligence quotient (IQ) score in children | Baseline risk of dental aberrations | Mortality in Finland
Environmental variables Concentrations of beneficial nutrients in fish | Mercury and methyl mercury concentrations in fish | Concentrations of PCDD/Fs in fish | Concentrations of PCBs in fish
Exposure variables Fish oil intake in Beneris | Methyl mercury intake from fish in Beneris | Iodine intake from fish in Beneris | Intake of PCB from fish in Beneris | Intake of PCDD/F from fish in Beneris | Domestic fish consumption of the general population in Finland | Domestic fish consumption of the pregnant women in Finland |
Exposure-response functions ERF of omega-3 fatty acids on intelligence quotient | ERF of omega-3 fatty acids on CVD risk in adults | ERF of methyl mercury on intelligence quotient | ERF of methyl mercury on myocardial infarction | ERF of methyl mercury on CVD risk in adults | Variable:Exposure-response of iodine intake for IQ change in children | Variable:Exposure-response of PCB intake for dental aberrations risk in children |  ERF of PCB on cancer | Variable:Exposure-response of PCDD/F intake for dental aberrations risk in children | ERF of dioxin on cancer | Variable:Exposure-response of PCDD/F intake for cancer risk in adults |
Health effect variables Risk of dental aberrations in children in Beneris | Intelligence quotient (IQ) in children in Beneris | Myocardial infarction risk in adults in Beneris | Total cancer risk in adults in Beneris | Net health effects in Beneris |


Nutritional benefits and risks of PCDD/F exposure of fish consumption in Finnish children and adults Analytica model
Beneris:Risk assessment of MeHg and n-3 fatty acids in fish

Indexes

Fish species
  • Baltic herring (Clupea harengus membras)
  • Herring (Clupea harengus)
  • Vendace (Coregonus albula)
  • Whitefish (Coregonus lavaretus)
  • Pike (Esox lucius)
  • Rainbow trout (Onchorhynchus mykiss)
  • Shrimp (Pandalus sp.)
  • Perch (Perca fluviatilis)
  • Saithe (Pollachius virens)
  • Atlantic salmon (Salmo salar)
  • Pike-perch (Sander lucioperca)
  • Tuna (Thunnus thynnus)
Nutrients
  • Omega-3 fatty acids
  • Selenium
  • Iodine
  • Vitamin D
  • Vitamin E
  • Group B vitamins

Age categorizations were chosen in order to describe health effects of fish consumption in infants (0-2 years, this class includes prenatal period as well), adolescent (2-18 years), adults (18-55 years) and elderly people (55-).

Age categories (years)
  • 0 - 2
  • 2 - 18
  • 18 - 55
  • 55 -

Result

{{#opasnet_base_link:Op_en1781}}


See also


EU funded projects from Cordis database

References

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