<?xml version="1.0" encoding="UTF-8" standalone="yes"?>
<ana user="akau" project="Rba_fish_diox_child" generated="5. Novta 2007 12:07 " softwareversion="3.1.2" software="Analytica">
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  <definition>0</definition>
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 <sysvar name="Time">
  <title>Time</title>
  <description>Dynamic simulation periods are specified in Time's definition. This is usually a list of numbers or labels, typically in some unit of time (days, weeks, months, etc.).  Use the &#xD2;Dynamic()&#xD3; function in your variables to perform dynamic simulation.</description>
  <definition>[0,1,2]</definition>
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 <model name="Rba_fish_diox_child">
  <title>Risk-benefit assessment of fish dioxins (PCDD/Fs) and an aggregate of nutritional benefits: childhood risks and benefits as compared to average adults.</title>
  <description>Introduction to the model:

Our food choices are commonly known to have a crucial role on the overall psychosomatic wellbeing in various phases of life. Not in the slightest, the nutritional state of bearing mothers has a crucial bearing on the forthcoming health of an individual. Fish, as clearly being a beneficial food, is an excellent source of many nutrients such as vitamin D, polyunsaturated n-3 fatty acids and selenium to mention a few. However, even healthy food can pose risks. Fish, especially the top predators via their habitat in aquatic ecosystems, are susceptible to biomagnification of lipophilic and persistent environmental contaminants such as polychlorinated dibenzodioxins (PCDDs) and dibenzofurans (PCDFs), polychlorinated biphenyls (PCBs) and methyl mercury (Met-Hg). Since there are hardly a place in the world with no detectable environmental contamination, the exposure risk for human through fish consumption is predominant.

A future challenge in environmental health risk assessment will be how to effectively incorporate the multitude of consequences of environmental issues and hazards related to children's health into forthcoming practices in risk assessment and management. To touch on this delicate issue from the food-borne risks' point of view, a detailed risk-benefit analysis by means of uncertainty-incorporated probability distributions on the role of fish in the diet of adults as compared to children of a Finnish average population is presented in this model. 

This model focuses on risks of PCDD/Fs and nutritional benefits of fish consumption on childhood and adult health. Potential health indicator risk endpoints are neurodevelopmental defects and cardiovascular , brain function and mental health for children and adults, respectively. As broad health indicator beneficial endpoints as reasonable will be incorporated into the model. The most potential ones include n-3 PUFAs, vitamin D and ___.  Noteworthy, the model also aims to evaluate both the prenatal and lactation-related risks and benefits of fish consumption. MALLIN KUNNIANHIMOINEN (laaja-alainen) FOCUS VAATII VIEL&#x80; PALJON T&#x80;SMENNYST&#x80; YLIMALKAAN ONNISTUAKSEEN K&#x80;YT&#x80;NN&#x85;SS&#x80;. 

Also an attemp to evaluate useful elements and limitations associated with the application of this risk-benefit model as well as their implications to societal decision-making and risk management on human health issues  will be made.</description>
  <author>Anna Karjalainen, Jouni Tuomisto, Olli Leino, Marjo Niittynen</author>
  <date>4. Septa 2007 11:58</date>
  <saveauthor>akau</saveauthor>
  <savedate>5. Novta 2007 12:07</savedate>
  <defaultsize>48,24</defaultsize>
  <diagstate>1,0,-23,1024,665,17</diagstate>
  <windstate>2,0,-23,1024,665</windstate>
  <fontstyle>Arial, 15</fontstyle>
  <fileinfo>0,Model Rba_fish_diox_child,2,2,0,1,C:\DATA\Beneris\Models\Fish case study\Valikaavio RBA Fish PCDDs A vs. C_25102007_ak_XML.ANA</fileinfo>
  <module name="Exposure_to_pcdd_fs">
   <title>Exposure to PCDD/Fs</title>
   <author>akau</author>
   <date>11. Octta 2007 12:23</date>
   <defaultsize>48,24</defaultsize>
   <nodelocation>304,232,1</nodelocation>
   <nodesize>48,24</nodesize>
   <nodeinfo>1,1,1,1,1,1,1,,0,</nodeinfo>
   <diagstate>1,0,-23,1024,665,17</diagstate>
   <diagramcolor>58982,58982,58982</diagramcolor>
   <nodefont>Arial, 13</nodefont>
   <variable name="Exposure_of_general_">
    <title>Exposure of general population to PCDD/Fs</title>
    <definition>FunctionOf(Pcdd_f_concn__in_dom; Expr; Expr;)</definition>
    <nodelocation>480,176,1</nodelocation>
    <nodesize>48,40</nodesize>
    <displayinputs>[Chance Pcddf_abs_eff]</displayinputs>
    <displayoutputs>[Variable Total_cancer_risk]</displayoutputs>
   </variable>
   <variable name="Exposure_of_pregnant">
    <title>Exposure of pregnant women to PCDD/Fs</title>
    <definition>FunctionOf(Pcdd_f_concn__in_dom; Expr; Expr)</definition>
    <nodelocation>352,176,1</nodelocation>
    <nodesize>48,40</nodesize>
    <windstate>2,0,-23,1025,666</windstate>
    <displayinputs>[Chance Pcddf_abs_eff]</displayinputs>
    <displayoutputs>[Constant Mother_s_pcdd_f_body]</displayoutputs>
   </variable>
   <variable name="Prenatal_exposure_to">
    <title>Prenatal exposure to PCDD/F</title>
    <definition>FunctionOf(Expr; Pcdd_f_concn__in_dom; Expr; Exposure_of_pregnant)</definition>
    <nodelocation>448,88,1</nodelocation>
    <nodesize>48,31</nodesize>
    <displayoutputs>[Constant Placenta_pcdd_f_conc, Variable Developmental_defect]</displayoutputs>
   </variable>
   <variable name="Suckling_exposure_to">
    <title>Suckling exposure to PCDD/Fs</title>
    <definition>FunctionOf(Expr; Expr; Pcdd_f_concn__in_dom; Exposure_of_pregnant)</definition>
    <nodelocation>352,40,1</nodelocation>
    <nodesize>48,32</nodesize>
    <displayoutputs>[Constant Placenta_pcdd_f_conc, Constant Mother_s_pcdd_f_body, Variable Developmental_defect]</displayoutputs>
   </variable>
   <constant name="Placenta_pcdd_f_conc">
    <title>Placenta PCDD/F concn. correspond with the concn. in breast milk</title>
    <nodelocation>168,88,1</nodelocation>
    <nodesize>68,44</nodesize>
    <windstate>2,0,-23,1025,666</windstate>
    <displayinputs>[Variable Prenatal_exposure_to, Variable Suckling_exposure_to]</displayinputs>
    <references>Abraham et al. (1998) in Kiviranta H. 2005. Exposure and human PCDD/F and PCB body burden in Finland. Academic dissertation, publications of the National public health Institute, 14/2005.</references>
   </constant>
   <constant name="Mother_s_pcdd_f_body">
    <title>Mother's PCDD/F body burden depletion in pregnancy and while lactating</title>
    <description>Approximately 20-30 % reduction in mother's PCDD/F body burden due to pregnancy and suckling is generally observed. This means that generally the second child  is exposed to PCDD/Fs both during pregnancy and through lactation 20-30 % less than the first child. Obviously some case-specific variation seen, which is dependent on sisters age diffrences.  In principal, mother's body burden depletion in her third-n pregnancies and breast feeding periods should be also 20-30 %, but is this certified as a correct assumption?

Mother's age affects considerable: the older the mother, the higher PCDD/F body burden she has gained during her lifespan.

Feeding habits affect considerably: the morre she has eaten PCDD/F containing products (especially fish in Finland) during her lifespan, the higher body burden she has.</description>
    <nodelocation>192,176,1</nodelocation>
    <nodesize>96,40</nodesize>
    <windstate>2,0,-23,1025,666</windstate>
    <displayinputs>[Variable Exposure_of_pregnant, Variable Suckling_exposure_to]</displayinputs>
   </constant>
   <chance name="Pcddf_abs_eff">
    <title>PCDD/F absorption efficiences</title>
    <units>proportion</units>
    <description>Absorption effeciences describe the the percentual assimilation or accumulation of the total amount taken in from fish eaten as proportions.

According to the reference below they are in the order of:
- 76-99% for TCDDs
- 87-99% for TCDFs</description>
    <nodelocation>408,272,1</nodelocation>
    <nodesize>56,32</nodesize>
    <windstate>2,0,-23,1024,665</windstate>
    <nodecolor>19661,65535,65535</nodecolor>
    <displayoutputs>[Variable Exposure_of_general_, Variable Exposure_of_pregnant]</displayoutputs>
    <references>&lt;a href=&quot;C:\DATA\Julkaisut\RBA Fish adults children julkaisut\Maruyma et al_2003_Chemosphere_Dioxin accumulation human tissues.pdf&quot;&gt;Maruyama W. et al. 2003&lt;/a&gt;
Maruyama W. et al. 2003. Simulation of dioxin accumulation in human tissues and analysis or reproductive risk. Chemosphere 53:301-313.
</references>
   </chance>
  </module>
  <module name="Fish_consumption">
   <title>Fish consumption</title>
   <author>akau</author>
   <date>11. Octta 2007 12:23</date>
   <defaultsize>48,24</defaultsize>
   <nodelocation>136,72,1</nodelocation>
   <nodesize>56,24</nodesize>
   <nodeinfo>1,1,1,1,1,1,1,,0,</nodeinfo>
   <diagstate>1,1,0,448,245,17</diagstate>
   <nodefont>Arial, 13</nodefont>
   <chance name="Domestic_fish_consu1">
    <title>Domestic fish consumption of a general population</title>
    <units>g/d of fish users</units>
    <definition>Table(Fish_species,Gender,Age_categories)(
Normal(5.717,5.897),Normal(11.548,12.958),Normal(29.611,39.023),
Normal(6.788,6.346),Normal(15.972,21.473),Normal(20.536,30.159),
Normal(0,0),Normal(3.333,2.47),Normal(19.843,15.217),
Normal(7.207,0),Normal(0,0),Normal(9.763,3.426),
Normal(7.858,7.6),Normal(8.884,10.204),Normal(37.081,49.405),
Normal(5.648,6.936),Normal(16.538,30.262),Normal(21.172,29.705),
Normal(10.053,8.227),Normal(19.395,23.573),Normal(52.569,64.867),
Normal(5.053,6.58),Normal(16.194,22.257),Normal(39.032,41.008),
Normal(3.636,2.402),Normal(3.684,3.106),Normal(26.13,32.603),
Normal(5.739,5.807),Normal(3.851,5.269),Normal(15.734,29.015),
Normal(9.686,7.075),Normal(17.59,14.058),Normal(66.308,48.587),
Normal(10.563,8.727),Normal(15.535,12.569),Normal(54.363,38.957),
Normal(0.663,1.339),Normal(4.328,4.142),Normal(19.94,26.408),
Normal(4.192,3.572),Normal(2.798,2.573),Normal(23.126,20.591),
Normal(5.807,3.15),Normal(14.644,29.199),Normal(20.305,31.374),
Normal(8.261,7.212),Normal(11.138,20.768),Normal(13.662,14.218),
Normal(10.09,7.458),Normal(16.479,14.435),Normal(54.505,32.059),
Normal(10.879,7.759),Normal(14.857,9.581),Normal(36.367,22.92),
Normal(13.82,14.23),Normal(18.79,19.343),Normal(24.946,19.845),
Normal(9.417,7.764),Normal(16.831,11.136),Normal(27.182,18.09),
Normal(18.647,18.83),Normal(22.52,17.775),'Normal(0.000)',
Normal(12.243,10.803),Normal(30.713,25.616),'Normal(0.000)',
Normal(7.981,6.591),Normal(7.733,8.539),Normal(47.431,39.261),
Normal(3.409,3.52),Normal(6.408,5.676),Normal(31.18,24.581)
)</definition>
    <nodelocation>160,248,1</nodelocation>
    <nodesize>72,36</nodesize>
    <nodeinfo>1,1,1,1,1,1,1,,0,</nodeinfo>
    <windstate>2,0,-23,1024,667</windstate>
    <defnstate>2,0,-23,1024,667,0,MIDM</defnstate>
    <valuestate>2,0,-23,1024,667,0,MIDM</valuestate>
    <nodecolor>65535,52427,65534</nodecolor>
    <nodefont>Arial, 13</nodefont>
    <reformdef>[Age_categories,Fish_species]</reformdef>
    <reformval>[Age_categories,Fish_species]</reformval>
    <references>&lt;a href=&quot;N:\YTOS\Projects\BENERIS\WP2\Datat pyydetyssa muodossa\Beneris_Food consumption_FINLAND_290307_th_ak.xls&quot;&gt;Fineli database on fish nutrient contents&lt;/a&gt;</references>
   </chance>
   <chance name="Domestic_fish_consu">
    <title>Domestic fish consumption of pregnant women</title>
    <definition>Table(Fish_species)(
Normal(3.539,4.046),Normal(0.0988,0.1122),Normal(0.9498,1.512),Normal(5.589,5.162),Normal(1.526,3.585),Normal(8.691,9.747),Normal(2.31,1.904),Normal(0.5699,1.161),Normal(7.822,6.761),Normal(1.636,1.713),Normal(0,0),Normal(6.192,7.883))</definition>
    <nodelocation>160,168,1</nodelocation>
    <nodesize>72,36</nodesize>
    <nodeinfo>1,1,1,1,1,1,1,,0,</nodeinfo>
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    <defnstate>2,0,-23,1024,667,0,MIDM</defnstate>
    <valuestate>2,0,-23,1024,667,0,MIDM</valuestate>
    <nodecolor>65535,52427,65534</nodecolor>
    <nodefont>Arial, 13</nodefont>
   </chance>
  </module>
  <index name="Fish_species">
   <title>Fish species</title>
   <definition>['Baltic herring (Clupea harengus membras)','Herring (Clupea harengus)','Vendace (Coregonus albula)','Whitefish (Coregonus lavaretus)','Pike (Esox lucius)','Rainbow trout (Onchorhynchus mykiss)','Shrimp (Pandalus sp.)','Perch (Perca fluviatilis)','Saithe (Pollachius virens)','Atlantic salmon (Salmo salar)','Pike-perch (Sander lucioperca)','Tuna (Thunnus thynnus)']</definition>
   <nodelocation>256,312,1</nodelocation>
   <nodesize>56,12</nodesize>
   <nodeinfo>1,1,1,1,1,1,1,,0,</nodeinfo>
   <windstate>2,0,-23,1025,666</windstate>
   <nodefont>Arial, 13</nodefont>
  </index>
  <index name="Gender">
   <title>Gender</title>
   <units>men or women</units>
   <definition>['men','women']</definition>
   <nodelocation>344,328,1</nodelocation>
   <nodesize>36,12</nodesize>
   <nodeinfo>1,1,1,1,1,1,1,,0,</nodeinfo>
   <windstate>2,0,-23,1025,666</windstate>
   <nodefont>Arial, 13</nodefont>
  </index>
  <index name="Age_categories">
   <title>Age categories</title>
   <units>year</units>
   <description>Class 0_2 describes exposure from pregnancy and lactatation to the age of 2 years.  
Class 2_18 describes exposure during childhood and puberty.
Class 18_55 describes exposure during adulthood.</description>
   <definition>['0_2','2_18','18_55']</definition>
   <nodelocation>248,344,1</nodelocation>
   <nodesize>56,12</nodesize>
   <nodeinfo>1,1,1,1,1,1,1,,0,</nodeinfo>
   <windstate>2,0,-23,1025,666</windstate>
   <nodefont>Arial, 13</nodefont>
  </index>
  <variable name="Pcdd_f_concn__in_dom">
   <title>PCDD/F concn. in domestic fish</title>
   <definition>FunctionOf(Expr; Expr)</definition>
   <nodelocation>136,232,1</nodelocation>
   <nodesize>56,24</nodesize>
   <nodeinfo>1,1,1,1,1,1,1,,0,</nodeinfo>
   <nodefont>Arial, 13</nodefont>
  </variable>
  <objective name="Net_health_effects_i">
   <title>Net health effects in adults</title>
   <description>Age group of adults= 18-55 years</description>
   <definition>FunctionOf(Expr; Expr; Expr)</definition>
   <nodelocation>680,240,1</nodelocation>
   <nodesize>60,24</nodesize>
   <nodeinfo>1,1,1,1,1,1,1,,0,</nodeinfo>
   <windstate>2,0,-23,1025,666</windstate>
   <nodefont>Arial, 13</nodefont>
   <displayinputs>[Text Te4, Variable Total_cancer_risk, Variable Omega_3_fatty_acid_p]</displayinputs>
  </objective>
  <objective name="Net_health_effects_2">
   <title>Net health effects in prenatal period and early childhood</title>
   <description>Prenatal period and early childhood=age group 0-2 years.
</description>
   <definition>FunctionOf(Expr; Expr; Expr; Expr; Expr; Expr; Expr; Expr)</definition>
   <nodelocation>680,80,1</nodelocation>
   <nodesize>72,29</nodesize>
   <nodeinfo>1,1,1,1,1,1,1,,0,</nodeinfo>
   <nodefont>Arial, 13</nodefont>
   <displayinputs>[Variable Developmental_defect, Variable Omega_3_fatty_acid_b]</displayinputs>
  </objective>
  <module name="Intake_of_omega_3_">
   <title>Intake of omega-3 (and other beneficial nutrients)</title>
   <author>akau</author>
   <date>11. Octta 2007 12:23</date>
   <defaultsize>48,24</defaultsize>
   <nodelocation>304,104,1</nodelocation>
   <nodesize>72,32</nodesize>
   <nodeinfo>1,1,1,1,1,1,1,,0,</nodeinfo>
   <diagstate>1,1,0,448,245,17</diagstate>
   <nodefont>Arial, 13</nodefont>
   <variable name="Omega_3_intake_by_pr">
    <title>Omega-3 intake by pregnant women</title>
    <units>mg/d</units>
    <definition>Omega_3_fatty_acid_c*Domestic_fish_consu</definition>
    <nodelocation>112,104,1</nodelocation>
    <nodesize>48,38</nodesize>
    <nodeinfo>1,1,1,1,1,1,1,,0,</nodeinfo>
    <windstate>2,0,-23,1024,667</windstate>
    <valuestate>2,0,-23,1024,667,1,PDFP</valuestate>
    <nodefont>Arial, 13</nodefont>
    <att__discretenessinf>[0, 0, 0, 0 ]</att__discretenessinf>
   </variable>
   <variable name="Prenatal_intake_of_o">
    <title>Prenatal intake of omega-3 fatty acids</title>
    <units>mg/d</units>
    <description>Periaatteessa 1:1, mutta t&#x8A;m&#x8A; pit&#x8A;&#x8A; tarkentaa kirjallisuudesta.</description>
    <definition>Omega_3_intake_by_pr*1</definition>
    <nodelocation>256,104,1</nodelocation>
    <nodesize>64,28</nodesize>
    <nodeinfo>1,1,1,1,1,1,1,,0,</nodeinfo>
    <nodefont>Arial, 13</nodefont>
    <displayoutputs>[Variable Omega_3_fatty_acid_b]</displayoutputs>
   </variable>
   <variable name="Suckling_intake_of_o">
    <title>Suckling intake of omega-3 fatty acids</title>
    <description>Periaatteessa 1:1, mutta t&#x8A;m&#x8A; pit&#x8A;&#x8A; tarkentaa kirjallisuudesta.</description>
    <definition>Omega_3_intake_by_pr*1</definition>
    <nodelocation>256,176,1</nodelocation>
    <nodesize>60,28</nodesize>
    <nodeinfo>1,1,1,1,1,1,1,,0,</nodeinfo>
    <nodefont>Arial, 13</nodefont>
    <displayoutputs>[Variable Omega_3_fatty_acid_b]</displayoutputs>
   </variable>
   <variable name="Omega_3_intake_in_an">
    <title>Omega-3 intake in an average population</title>
    <units>mg/d</units>
    <description>Omega-3 intake in an average population from the documented fish consumption</description>
    <definition>Omega_3_fatty_acid_c*Domestic_fish_consu1</definition>
    <nodelocation>112,192,1</nodelocation>
    <nodesize>48,38</nodesize>
    <nodeinfo>1,1,1,1,1,1,1,,0,</nodeinfo>
    <nodefont>Arial, 13</nodefont>
    <displayoutputs>[Variable Omega_3_fatty_acid_p]</displayoutputs>
   </variable>
  </module>
  <index name="Nutrient_intakes">
   <title>Nutrient intakes</title>
   <units>mass unit/day</units>
   <definition>['Omega-3 fatty acids, mg/d','Vitamin D, ug/d','Vitamin E, mg/d','Selenium,ug/d','Iodine, ug/d','Group B vitamins, mg/d']</definition>
   <nodelocation>136,344,1</nodelocation>
   <nodesize>56,12</nodesize>
   <nodeinfo>1,1,1,1,1,1,1,,0,</nodeinfo>
   <windstate>2,409,32,476,224</windstate>
   <nodefont>Arial, 13</nodefont>
  </index>
  <objective name="Early_lifetime_vs__a">
   <title>Early lifetime vs. adulthood risks and benefits of fish consumption</title>
   <definition>Net_health_effects_i; Net_health_effects_2; Net_health_effects_1</definition>
   <nodelocation>864,160,1</nodelocation>
   <nodesize>76,38</nodesize>
   <nodeinfo>1,1,1,1,1,1,1,,0,</nodeinfo>
   <nodefont>Arial, 13</nodefont>
  </objective>
  <objective name="Net_health_effects_1">
   <title>Net health effects in childhood and puberty</title>
   <description>Childhood period and puberty=  age group of 2-18 years.
</description>
   <definition>FunctionOf(Expr; Expr; Expr; Expr)</definition>
   <nodelocation>680,168,1</nodelocation>
   <nodesize>64,29</nodesize>
   <nodeinfo>1,1,1,1,1,1,1,,0,</nodeinfo>
   <nodefont>Arial, 13</nodefont>
   <displayinputs>[Variable Developmental_defect, Variable Omega_3_fatty_acid_b]</displayinputs>
  </objective>
  <text name="Te2">
   <description>Source information</description>
   <nodelocation>136,176,-8</nodelocation>
   <nodesize>80,164</nodesize>
   <nodeinfo>1,0,0,1,0,1,1,,0,</nodeinfo>
   <nodecolor>65535,65533,52427</nodecolor>
   <nodefont>Arial, 13</nodefont>
  </text>
  <text name="Te3">
   <description>Exposure and intakes</description>
   <nodelocation>304,176,-7</nodelocation>
   <nodesize>92,164</nodesize>
   <nodeinfo>1,0,0,1,0,1,1,,0,</nodeinfo>
   <nodecolor>65535,65531,39321</nodecolor>
   <nodefont>Arial, 13</nodefont>
  </text>
  <text name="Te4">
   <description>Net health effects</description>
   <nodelocation>680,152,-6</nodelocation>
   <nodesize>96,138</nodesize>
   <nodeinfo>1,0,0,1,0,1,1,,0,</nodeinfo>
   <windstate>2,0,-23,1025,666</windstate>
   <nodecolor>52428,65535,52427</nodecolor>
   <nodefont>Arial, 13</nodefont>
   <displayoutputs>[Objective Net_health_effects_i]</displayoutputs>
  </text>
  <text name="Te5">
   <description>Age-category comparisons,
Susceptible age groups vs. adults</description>
   <nodelocation>864,150,-5</nodelocation>
   <nodesize>92,138</nodesize>
   <nodeinfo>1,0,0,1,0,1,1,,0,</nodeinfo>
   <nodecolor>65535,55703,52427</nodecolor>
   <nodefont>Arial, 13</nodefont>
  </text>
  <text name="Te6">
   <description>Critical hazardous indicators</description>
   <nodelocation>488,280,-4</nodelocation>
   <nodesize>96,84</nodesize>
   <nodeinfo>1,0,0,1,0,1,1,,0,</nodeinfo>
   <nodecolor>52427,60621,65535</nodecolor>
   <nodefont>Arial, 13</nodefont>
  </text>
  <variable name="Developmental_defect">
   <title>Developmental defects in teeth</title>
   <nodelocation>488,248,1</nodelocation>
   <nodesize>60,24</nodesize>
   <nodeinfo>1,1,1,1,1,1,1,,0,</nodeinfo>
   <nodefont>Arial, 13</nodefont>
   <displayinputs>[Variable Prenatal_exposure_to, Variable Suckling_exposure_to]</displayinputs>
   <displayoutputs>[Objective Net_health_effects_2, Objective Net_health_effects_1]</displayoutputs>
  </variable>
  <variable name="Total_cancer_risk">
   <title>Total Cancer risk</title>
   <description>U.S.EPA cancer slope factor used here for describing the total cancer risk due to exposure to dioxins.</description>
   <nodelocation>488,312,1</nodelocation>
   <nodesize>48,24</nodesize>
   <nodeinfo>1,1,1,1,1,1,1,,0,</nodeinfo>
   <windstate>2,0,-23,1025,666</windstate>
   <nodefont>Arial, 13</nodefont>
   <displayinputs>[Variable Exposure_of_general_]</displayinputs>
   <displayoutputs>[Objective Net_health_effects_i]</displayoutputs>
  </variable>
  <index name="Nutrient_concn_">
   <title>Nutrient concn.</title>
   <units>mass unit/g</units>
   <definition>['Omega-3 fatty acids, mg/g','Vitamin D, ug/g','Vitamin E, mg/g','Selenium,ug/g','Iodine, ug/g','Group B vitamins, mg/g']</definition>
   <nodelocation>144,312,1</nodelocation>
   <nodesize>56,12</nodesize>
   <nodeinfo>1,1,1,1,1,1,1,,0,</nodeinfo>
   <windstate>2,0,-23,1024,667</windstate>
   <nodefont>Arial, 13</nodefont>
  </index>
  <text name="Te8">
   <description>Critical beneficial indicators</description>
   <nodelocation>488,104,-3</nodelocation>
   <nodesize>96,92</nodesize>
   <nodeinfo>1,0,0,1,0,1,1,,0,</nodeinfo>
   <nodecolor>58978,52427,65535</nodecolor>
   <nodefont>Arial, 13</nodefont>
  </text>
  <variable name="Omega_3_fatty_acid_p">
   <title>Omega-3 fatty acid protection against cancer</title>
   <nodelocation>488,160,1</nodelocation>
   <nodesize>60,28</nodesize>
   <nodeinfo>1,1,1,1,1,1,1,,0,</nodeinfo>
   <nodefont>Arial, 13</nodefont>
   <displayinputs>[Variable Omega_3_intake_in_an]</displayinputs>
   <displayoutputs>[Objective Net_health_effects_i]</displayoutputs>
  </variable>
  <variable name="Omega_3_fatty_acid_b">
   <title>Omega-3 fatty acid beneficial effects on central nervous system development</title>
   <description>Omega-3 fatty acid beneficial effects on central nervous system development descried as attained (added?) intelligence quotient, IQ at a certain age</description>
   <nodelocation>488,80,1</nodelocation>
   <nodesize>80,40</nodesize>
   <nodeinfo>1,1,1,1,1,1,1,,0,</nodeinfo>
   <nodefont>Arial, 13</nodefont>
   <displayinputs>[Variable Prenatal_intake_of_o, Variable Suckling_intake_of_o]</displayinputs>
   <displayoutputs>[Objective Net_health_effects_2, Objective Net_health_effects_1]</displayoutputs>
  </variable>
  <text name="Te12">
   <description>                                  Indexes</description>
   <nodelocation>224,320,-1</nodelocation>
   <nodesize>168,44</nodesize>
   <nodeinfo>1,0,0,1,0,1,1,,0,</nodeinfo>
   <nodefont>Arial, 13</nodefont>
  </text>
  <module name="Beneficial_nutrient_">
   <title>Beneficial nutrient concn. in fish</title>
   <defaultsize>48,24</defaultsize>
   <nodelocation>136,144,1</nodelocation>
   <nodesize>56,32</nodesize>
   <nodeinfo>1,1,1,1,1,1,1,,0,</nodeinfo>
   <nodefont>Arial, 13</nodefont>
   <variable name="Concn__of_beneficial">
    <title>Concn. of beneficial nutrients in various fish species</title>
    <units>mass units/g fish</units>
    <description>Concentrations of beneficial nutrients in fish extracted from the FIneli database, where they are indicated as mass units/100 g fish analysed.  Criteria for choosing the fish preparation method used prior the analyses:
1) one that is presumed as a common one used by the Finnish 
consumers (roasting), and
2) also as available for most of the fish in the database.

-Omega-3 fatty acids, mg/g, as sum of n-3 PUFA (polyunsaturated fatty acids) precursors ALA (alphalinoleic acid), EPA (eicosapanthenic acid), and DHA (docosahexaenoic acid). DPA (docosapentaenoic acid) not available in the database.
-Vitamin D, ug/g
-Vitamin E, mg/g
-Selenium, ug/g
-Iodine, ug/g
-Group B vitamins, mg/g, as sum of B1 (tiamin), B2 (riboflavin),  B6 (pyridoxin),  B12 (cyanokobalamin) and niacin as its eqvivalents NE.  Incorporation does not reflect any functional entity (its usefulness needs to be further reassessed).

See the reference below for further information for instance on the preparation ingredients used.

</description>
    <definition>Table(Fish_species,Nutrient_concn_)(
(((490+232)+491)/100),(17.5/100),(3.1/100),(17.9/100),(45/100),(((((5.7+0.16)+0.02)+11.3)+0.24)/100),
(((490+232)+491)/100),(17.5/100),(3.1/100),(17.9/100),(45/100),(((((5.7+0.16)+0.02)+11.3)+0.24)/100),
(((669+204)+404)/100),(13.1/100),(2.9/100),(21.9/100),(75.6/100),0,
(((388+238)+445)/100),0,0,0,0,0,
(((441+40)+194)/100),(3/100),(2/100),(22.2/100),(33.9/100),(((((5.4+0.08)+0.09)+1.7)+0.23)/100),
(((583+369)+1100)/100),0,0,0,0,0,
(((3+124)+122)/100),0,0,0,0,0,
(((413+55)+249)/100),0,0,0,0,0,
(((5+102)+280)/100),0,0,0,0,0,
(((539+308)+895)/100),0,0,0,0,0,
(((13+92)+301)/100),0,0,0,0,0,
(((225+1014)+2028)/100),0,0,0,0,0
)</definition>
    <nodelocation>168,136,1</nodelocation>
    <nodesize>72,28</nodesize>
    <nodeinfo>1,1,1,1,1,1,1,,0,</nodeinfo>
    <windstate>2,0,-23,1024,667</windstate>
    <defnstate>2,0,-23,1024,667,0,MIDM</defnstate>
    <valuestate>2,0,-23,1024,667,1,MIDM</valuestate>
    <nodecolor>65535,52427,65534</nodecolor>
    <nodefont>Arial, 13</nodefont>
    <reformdef>[Nutrient_concn_,Fish_species]</reformdef>
    <reformval>[Self,Fish_species]</reformval>
    <numberformat>1,F,4,2,0,0</numberformat>
    <att__discretenessinf>[0, 0, 0, 0 ]</att__discretenessinf>
    <references>&lt;a href=&quot;http://www.fineli.fi/foodclass.php?classif=fuclass&amp;class=fish&amp;lang=fi&quot;&gt;Fineli database on fisn nutrient contents&lt;/a&gt;
</references>
   </variable>
   <variable name="Omega_3_fatty_acid_c">
    <title>Omega-3-fatty acid concn.in various fish species</title>
    <units>mg/g fish</units>
    <description>Currently, only omega-3-fatty acids taken into account as health benefits of fish consumption.</description>
    <definition>Slice(Concn__of_beneficial,Nutrient_concn_,1)</definition>
    <nodelocation>168,224,1</nodelocation>
    <nodesize>64,32</nodesize>
    <nodeinfo>1,1,1,1,1,1,1,,0,</nodeinfo>
    <windstate>2,0,-23,1024,667</windstate>
    <valuestate>2,0,-23,1024,667,0,MIDM</valuestate>
    <nodecolor>65535,52427,65534</nodecolor>
    <nodefont>Arial, 13</nodefont>
    <references>&lt;a href=&quot;http://www.fineli.fi/foodclass.php?classif=fuclass&amp;class=fish&amp;lang=fi&quot;&gt;Fineli database on fisn nutrient contents&lt;/a&gt;</references>
   </variable>
  </module>
 </model>
</ana>