ERF of indoor dampness on respiratory health effects: Difference between revisions

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[[Category: CLAIH]]
[[Category: CLAIH]]
[[Category:Urgenche]]
[[Category:Urgenche]]
[[Category:Contains R code]]
{{variable|moderator=Ulla H-S}}
{{variable|moderator=Ulla H-S}}
{{defend|# |Very good comments and work on this page!|--[[User:Jouni|Jouni]] 00:12, 7 February 2013 (EET)}}


Exposure-response function of exposure to indoor dampness and/or mold or mold odor and respiratory health effects. The exposure-response function is expressed as ERF.  
Exposure-response function of exposure to indoor dampness and/or mold or mold odor and respiratory health effects. The exposure-response function is expressed as ERF.  
{{comment|# |We added a short summary|--[[User:Isabell Rumrich|Isabell Rumrich]] 10:56, 4 February 2013 (EET)}}


== Question ==
== Question ==


What is the association between exposure to indoor dampness and mould in homes and respiratory health effects? {{defend|# |The question is clear.|--[[User:Isabell Rumrich|Isabell Rumrich]] 10:27, 4 February 2013 (EET)}}
What is the association between exposure to indoor dampness and mould in homes and respiratory health effects?


== Answer ==
== Answer ==


'''Exposure-response function
'''Exposure-response function
{{comment|# |We understand how the ovariable is connected to this table, but not how the data were used in detail in a mathematical way to have the answer. This is the reason why we did not add a R-code for it|--[[User:Isabell Rumrich|Isabell Rumrich]] 11:01, 4 February 2013 (EET)}}
{{comment|# |You might want to look at [[ERF of several environmental pollutions‎‎]], which was updated today and is very similar to your page.|--[[User:Jouni|Jouni]] 00:12, 7 February 2013 (EET)}}
{{defend|# |Yes, now the code works.|--[[User:Stefania|Stefania]] 10:23, 11 February 2013 (EET)}}


<rcode graphics="1">
<rcode graphics="1">
Line 36: Line 26:
objects.latest("Op_en4716", "calculations") # Get the latest ovariables from code calculations on page Op_en4716.
objects.latest("Op_en4716", "calculations") # Get the latest ovariables from code calculations on page Op_en4716.


ERFindoorDampnessOnRespiratoryHealthEffects <- EvalOutput(ERFindoorDampnessOnRespiratoryHealthEffects, N = 3)
ERF <- EvalOutput(ERF, N = 100)
print(xtable(ERFindoorDampnessOnRespiratoryHealthEffects@output, digits = 4), type = 'html')
#ERFindoorDampnessOnRespiratoryHealthEffects@output$ERFindoorDampnessOnRespiratoryHealthEffectsResult <- as.numeric(as.character(ERFindoorDampnessOnRespiratoryHealthEffects@output$ERFindoorDampnessOnRespiratoryHealthEffectsResult))
#ERFindoorDampnessOnRespiratoryHealthEffects@output <- ERFindoorDampnessOnRespiratoryHealthEffects@output[colnames(ERFindoorDampnessOnRespiratoryHealthEffects@output) != "Obs"]
 


ERF@output <- data.frame(ERF@output, Pollutant = "Indoor.dampness") # This is needed because the Pollutant column is missing from the data table.


ggplot(ERFindoorDampnessOnRespiratoryHealthEffects@output[ERFindoorDampnessOnRespiratoryHealthEffects@output$ERFindoorDampnessOnRespiratoryHealthEffects.Parameter == "RR" , ], # Show a bar chart
print(xtable(ERF@output[ERF@output$Iter == 1 , ], digits = 4), type = 'html')
aes(x = Pollutant, y = ERFindoorDampnessOnRespiratoryHealthEffectsResult, fill = Response.metric)) +
geom_bar(position="dodge") +
theme_grey(base_size = 24) +
theme(axis.text.x = element_text(angle = 90, hjust = 1))


ggplot(ERFindoorDampnessOnRespiratoryHealthEffects@output[ERFindoorDampnessOnRespiratoryHealthEffects@output$ERFindoorDampnessOnRespiratoryHealthEffects.Parameter == "UR" , ], # Show a bar chart
ggplot(ERF@output[ERF@output$ERF.parameter == "OR" , ], # Show a  
aes(x = Health.impact, y = ERFindoorDampnessOnRespiratoryHealthEffectsResult, fill = Response.metric)) +
aes(x = Disease, y = ERFResult)) + # , fill = Response.metric)) +
geom_bar(position="dodge") +  
geom_boxplot() +  
theme_grey(base_size = 24) +
theme_grey(base_size = 24) +
theme(axis.text.x = element_text(angle = 90, hjust = 1))
theme(axis.text.x = element_text(angle = 90, hjust = 1))


</rcode>
</rcode>


== Rationale==
== Rationale==
Line 63: Line 44:
=== Data ===
=== Data ===


<t2b index="Disease,Response metric,Subjects,Exposure route,Exposure metric,Exposure unit,ERF parameter,Threshold,Observation" locations="ERF,Description" unit=" OR per yes/no visible dampness and/or mold or mold odor
<t2b index="Disease,Response metric,Subjects,Exposure route,Exposure metric,Exposure unit,ERF parameter,Threshold,Observation" locations="Result,Description" unit=" OR per yes/no visible dampness and/or mold or mold odor
">
">
Upper respiratory tract symptoms||All|Inhalation|visible dampness and/or mold or mold odor|yes/no|OR|0|1.70|1.70 (1.44-2.00), No. studies: 13
Upper respiratory tract symptoms||All|Inhalation|visible dampness and/or mold or mold odor|yes/no|OR|0|1.70 (1.44-2.00)| No. studies: 13
Cough||All|Inhalation|visible dampness and/or mold or mold odor|yes/no|OR|0|1.67|1.67 (1.49-1.86), No. studies: 18
Cough||All|Inhalation|visible dampness and/or mold or mold odor|yes/no|OR|0|1.67 (1.49-1.86)| No. studies: 18
Cough||Adults|Inhalation|visible dampness and/or mold or mold odor|yes/no|OR|0|1.52|1.52 (1.18-1.96), No. studies: 6
Cough||Adults|Inhalation|visible dampness and/or mold or mold odor|yes/no|OR|0|1.52 (1.18-1.96)| No. studies: 6
Cough||Children|Inhalation|visible dampness and/or mold or mold odor|yes/no|OR|0|1.75|1.75 (1.56-1.96), No. studies: 6
Cough||Children|Inhalation|visible dampness and/or mold or mold odor|yes/no|OR|0|1.75 (1.56-1.96)| No. studies: 6
Wheeze||All|Inhalation|visible dampness and/or mold or mold odor|yes/no|OR|0|1.50|1.50 (1.38-1.64), No. studies: 22
Wheeze||All|Inhalation|visible dampness and/or mold or mold odor|yes/no|OR|0|1.50 (1.38-1.64)| No. studies: 22
Wheeze||Adults|Inhalation|visible dampness and/or mold or mold odor|yes/no|OR|0|1.39|1.39 (1.04-1.85), No. studies: 5
Wheeze||Adults|Inhalation|visible dampness and/or mold or mold odor|yes/no|OR|0|1.39 (1.04-1.85)| No. studies: 5
Wheeze||Children|Inhalation|visible dampness and/or mold or mold odor|yes/no|OR|0|1.53|1.53 (1.39-1.68), No. studies: 17
Wheeze||Children|Inhalation|visible dampness and/or mold or mold odor|yes/no|OR|0|1.53 (1.39-1.68)| No. studies: 17
Current asthma||All|Inhalation|visible dampness and/or mold or mold odor|yes/no|OR|0|1.56|1.56 (1.30-1.86), No. studies: 10
Current asthma||All|Inhalation|visible dampness and/or mold or mold odor|yes/no|OR|0|1.56 (1.30-1.86)| No. studies: 10
Ever-diagnosed asthma||All|Inhalation|visible dampness and/or mold or mold odor|yes/no|OR|0|1.37|1.37 (1.23-1.53), No. studies: 8
Ever-diagnosed asthma||All|Inhalation|visible dampness and/or mold or mold odor|yes/no|OR|0|1.37 (1.23-1.53)| No. studies: 8
Ever-diagnosed asthma||Children|Inhalation|visible dampness and/or mold or mold odor|yes/no|OR|0|1.35|1.35 (1.20-1.51), No. studies: -
Ever-diagnosed asthma||Children|Inhalation|visible dampness and/or mold or mold odor|yes/no|OR|0|1.35 (1.20-1.51)| No. studies: -
Asthma development||All|Inhalation|visible dampness and/or mold or mold odor|yes/no|OR|0|1.34|1.34 (0.86-2.10), No. studies: 4
Asthma development||All|Inhalation|visible dampness and/or mold or mold odor|yes/no|OR|0|1.34 (0.86-2.10)| No. studies: 4
Bronchitis||All|Inhalation|visible dampness and/or mold or mold odor|yes/no|OR|0|1.45|1.45 (1.32-1.59), No. studies: -
Bronchitis||All|Inhalation|visible dampness and/or mold or mold odor|yes/no|OR|0|1.45 (1.32-1.59)| No. studies: -
Bronchitis||Children|Inhalation|visible dampness and/or mold or mold odor|yes/no|OR|0|1.38|1.38 (1.28-1.47), No. studies: -
Bronchitis||Children|Inhalation|visible dampness and/or mold or mold odor|yes/no|OR|0|1.38 (1.28-1.47)| No. studies: -
Respiratory infections||All|Inhalation|visible dampness and/or mold or mold odor|yes/no|OR|0|1.44|1.44 (1.31-1.59), No. studies: -
Respiratory infections||All|Inhalation|visible dampness and/or mold or mold odor|yes/no|OR|0|1.44 (1.31-1.59)| No. studies: -
Respiratory infections||Adults|Inhalation|visible dampness and/or mold or mold odor|yes/no|OR|0|1.49|1.49 (1.14-1.95), No. studies: -
Respiratory infections||Adults|Inhalation|visible dampness and/or mold or mold odor|yes/no|OR|0|1.49 (1.14-1.95)| No. studies: -
Respiratory infections||Children|Inhalation|visible dampness and/or mold or mold odor|yes/no|OR|0|1.48|1.48 (1.33-1.65), No. studies: -
Respiratory infections||Children|Inhalation|visible dampness and/or mold or mold odor|yes/no|OR|0|1.48 (1.33-1.65)| No. studies: -
Sensitivity to inhaled antigens||Children|Inhalation|visible dampness and/or mold or mold odor|yes/no|OR|0|1.33|1.33 (1.23-1.44), No. studies: -
Sensitivity to inhaled antigens||Children|Inhalation|visible dampness and/or mold or mold odor|yes/no|OR|0|1.33 (1.23-1.44)| No. studies: -
Hay fever||Children|Inhalation|visible dampness and/or mold or mold odor|yes/no|OR|0|1.35|1.35 (1.18-1.53), No. studies: -
Hay fever||Children|Inhalation|visible dampness and/or mold or mold odor|yes/no|OR|0|1.35 (1.18-1.53)| No. studies: -
</t2b>
</t2b>
<ref>W. J. Fisk, Q. Lei-Gomez, M. J. Mendell. Meta-analyses of the associations of respiratory health e?ects with dampness and mold in homes. Indoor Air 2007; 17: 284–296. {{doi|10.1111/j.1600-0668.2007.00475.x}}</ref> <ref>[http://ehp03.niehs.nih.gov/article/fetchArticle.action?articleURI=info%3Adoi%2F10.1289%2Fehp.1002410 Mendell et al. 2011. Respiratory and allergic health effects of dampness and mold, and dampness-related agents: a review of the epidemiological evidence. Environmental Health Perspectives 119(6), 748-756.]</ref>


Page-specific entries (indices that have exactly one value each for the whole variable; usually mentioned in the title and/or in the scope.):
Page-specific entries (indices that have exactly one value each for the whole variable; usually mentioned in the title and/or in the scope.):
Line 91: Line 74:
* Exposure route: Inhalation
* Exposure route: Inhalation


===Unit===


{{comment|# |You can leave the columns listed above out of the table, because all rows have the same value. If you do, then you MUST put the respective information to [[:Category:Exposure-response functions]].|--[[User:Jouni|Jouni]] 17:38, 23 January 2012 (EET)}}
[[OR]] for yes vs. no visible dampness and/or mold or mold odor
 
{{attack|# |If possible, "Disease" should be something that has an ICT-10 code (in this case, the information that is in column "Response metric". In contrast, "Response metric" should describe how the disease was measured: number of cases, incidence, prevalence,...|--[[User:Jouni|Jouni]] 17:38, 23 January 2012 (EET)}}
 
{{attack|# |The comment emphasizing some changes is more than a year old and there are no changes or any kind of reactions to it.|--[[User:Isabell Rumrich|Isabell Rumrich]] 10:29, 4 February 2013 (EET)}}
 
 
{{comment|# |The table below is kind of a repetition.|--[[User:Jouni|Jouni]] 00:12, 7 February 2013 (EET)}}
 
{| {{prettytable}}
|+ '''Odds ratios for different health effects in homes with vs. without visible dampness and/or mold or mold odor.
<ref>W. J. Fisk, Q. Lei-Gomez, M. J. Mendell. Meta-analyses of the associations of respiratory health effects with dampness and mold in homes. Indoor Air 2007; 17: 284–296. {{doi|10.1111/j.1600-0668.2007.00475.x}}</ref> <ref>[http://ehp03.niehs.nih.gov/article/fetchArticle.action?articleURI=info%3Adoi%2F10.1289%2Fehp.1002410 Mendell et al. 2011. Respiratory and allergic health effects of dampness and mold, and dampness-related agents: a review of the epidemiological evidence. Environmental Health Perspectives 119(6), 748-756.]</ref>
!Outcome
! Subjects
! No. studies
! Odds ratio central estimate (95 % CI)
! Estimated % increase in damp homes
|----
| Upper respiratory tract symptoms || All  || 13  || 1.70 (1.44–2.00)  || 52
|----
|rowspan="3" | Cough  || All  || 18  || 1.67 (1.49–1.86)  || 50
|----
| Adults  || 6  || 1.52 (1.18–1.96)  || –
|----
| Children  || 12  || 1.75 (1.56–1.96)  || –
|----
| rowspan="3" |Wheeze  || All  || 22  || 1.50 (1.38–1.64)  || 44
|----
| Adults  || 5  || 1.39 (1.04–1.85)  || –
|----
| Children  || 17  || 1.53 (1.39–1.68)  || –
|----
| Current asthma  || All  || 10  || 1.56 (1.30–1.86)  || 50
|----
| rowspan="2" |Ever-diagnosed asthma || All  || 8  || 1.37 (1.23–1.53)  || 33
|----
| Children  ||  || 1.35 (1.20–1.51)  ||
|----
| Asthma development || All  || 4  || 1.34 (0.86–2.10)  || 30
|----
| rowspan="2" |Bronchitis || All  ||  || 1.45 (1.32–1.59)  ||
|----
| Children  ||  || 1.38 (1.28–1.47)  ||
|----
| rowspan="3" |Respiratory infections || All  ||  || 1.44 (1.31–1.59)  ||
|----
| Adults  ||  || 1.49 (1.14–1.95)  ||
|----
| Children  ||  || 1.48 (1.33–1.65)  ||
|----
| Sensitivity to inhaled antigens || Children  ||  || 1.33 (1.23–1.44)  ||
|----
| Hay fever || Children  ||  || 1.35 (1.18–1.53)  ||
|}
 
=== Dependencies ===
 
{{comment|# |There are no dependencies listed yet, and we cannot come up with some.|--[[User:Isabell Rumrich|Isabell Rumrich]] 10:44, 4 February 2013 (EET)}}
 
=== Unit ===
 
{{attack|# |Unit is not a part of Rationale, it could be added to the data table.|--[[User:Isabell Rumrich|Isabell Rumrich]] 10:37, 4 February 2013 (EET)}}
 
[[OR]] per yes/no visible dampness and/or mold or mold odor


=== Calculations ===
=== Calculations ===


*Generates random samples of possible [[OR]]s.
<rcode label="Initiate variable" name="calculations">
**Normal distribution assumed, sd estimated from confidence interval using sd = (upper bound - lower bound)/3.92
 
 
<rcode name="calculations">
library(OpasnetUtils)
library(OpasnetUtils)
library(xtable)
library(xtable)


ERFindoorDampnessOnRespiratoryHealthEffects <- Ovariable("ERFindoorDampnessOnRespiratoryHealthEffects", ddata = "Op_en4716", getddata = FALSE, save = TRUE)  
ERF <- Ovariable("ERF", ddata = "Op_en4716", getddata = FALSE, save = TRUE)  


cat("Ovariable ERFindoorDampnessOnRespiratoryHealthEffects saved for later use. Page name: Op_en4716, code name: calculations\n")
cat("Ovariable ERF saved for later use. Page name: Op_en4716, code name: calculations\n")


print(xtable(EvalOutput(ERFindoorDampnessOnRespiratoryHealthEffects)@output), type = "html")
print(xtable(EvalOutput(ERF, N = 1)@output), type = "html")


</rcode>
</rcode>
{{defend|# |R-code runs now.|--[[User:Isabell Rumrich|Isabell Rumrich]] 10:30, 4 February 2013 (EET)}}


==See also==
==See also==
Line 185: Line 100:


Dampness and mould, ERF, Respiratory Disease, Asthma, Indoor Environment, Allergy
Dampness and mould, ERF, Respiratory Disease, Asthma, Indoor Environment, Allergy
{{comment|# |We added keywords.|--[[User:Isabell Rumrich|Isabell Rumrich]] 10:41, 4 February 2013 (EET)}}


==References==
==References==

Latest revision as of 10:14, 26 August 2013



Exposure-response function of exposure to indoor dampness and/or mold or mold odor and respiratory health effects. The exposure-response function is expressed as ERF.

Question

What is the association between exposure to indoor dampness and mould in homes and respiratory health effects?

Answer

Exposure-response function

+ Show code

Rationale

Data

ERF of indoor dampness on respiratory health effects: Difference between revisions(OR per yes/no visible dampness and/or mold or mold odor)
ObsDiseaseResponse metricSubjectsExposure routeExposure metricExposure unitERF parameterThresholdResultDescription
1Upper respiratory tract symptomsAllInhalationvisible dampness and/or mold or mold odoryes/noOR01.70 (1.44-2.00) No. studies: 13
2CoughAllInhalationvisible dampness and/or mold or mold odoryes/noOR01.67 (1.49-1.86) No. studies: 18
3CoughAdultsInhalationvisible dampness and/or mold or mold odoryes/noOR01.52 (1.18-1.96) No. studies: 6
4CoughChildrenInhalationvisible dampness and/or mold or mold odoryes/noOR01.75 (1.56-1.96) No. studies: 6
5WheezeAllInhalationvisible dampness and/or mold or mold odoryes/noOR01.50 (1.38-1.64) No. studies: 22
6WheezeAdultsInhalationvisible dampness and/or mold or mold odoryes/noOR01.39 (1.04-1.85) No. studies: 5
7WheezeChildrenInhalationvisible dampness and/or mold or mold odoryes/noOR01.53 (1.39-1.68) No. studies: 17
8Current asthmaAllInhalationvisible dampness and/or mold or mold odoryes/noOR01.56 (1.30-1.86) No. studies: 10
9Ever-diagnosed asthmaAllInhalationvisible dampness and/or mold or mold odoryes/noOR01.37 (1.23-1.53) No. studies: 8
10Ever-diagnosed asthmaChildrenInhalationvisible dampness and/or mold or mold odoryes/noOR01.35 (1.20-1.51) No. studies: -
11Asthma developmentAllInhalationvisible dampness and/or mold or mold odoryes/noOR01.34 (0.86-2.10) No. studies: 4
12BronchitisAllInhalationvisible dampness and/or mold or mold odoryes/noOR01.45 (1.32-1.59) No. studies: -
13BronchitisChildrenInhalationvisible dampness and/or mold or mold odoryes/noOR01.38 (1.28-1.47) No. studies: -
14Respiratory infectionsAllInhalationvisible dampness and/or mold or mold odoryes/noOR01.44 (1.31-1.59) No. studies: -
15Respiratory infectionsAdultsInhalationvisible dampness and/or mold or mold odoryes/noOR01.49 (1.14-1.95) No. studies: -
16Respiratory infectionsChildrenInhalationvisible dampness and/or mold or mold odoryes/noOR01.48 (1.33-1.65) No. studies: -
17Sensitivity to inhaled antigensChildrenInhalationvisible dampness and/or mold or mold odoryes/noOR01.33 (1.23-1.44) No. studies: -
18Hay feverChildrenInhalationvisible dampness and/or mold or mold odoryes/noOR01.35 (1.18-1.53) No. studies: -

[1] [2]

Page-specific entries (indices that have exactly one value each for the whole variable; usually mentioned in the title and/or in the scope.):

  • Pollutant: visible dampness and/or mold or mold odor
  • Threshold: 0
  • Exposure metric: yes/no
  • Exposure route: Inhalation

Unit

OR for yes vs. no visible dampness and/or mold or mold odor

Calculations

+ Show code

See also

Keywords

Dampness and mould, ERF, Respiratory Disease, Asthma, Indoor Environment, Allergy

References

  1. ↑ W. J. Fisk, Q. Lei-Gomez, M. J. Mendell. Meta-analyses of the associations of respiratory health e?ects with dampness and mold in homes. Indoor Air 2007; 17: 284–296. doi:10.1111/j.1600-0668.2007.00475.x
  2. ↑ Mendell et al. 2011. Respiratory and allergic health effects of dampness and mold, and dampness-related agents: a review of the epidemiological evidence. Environmental Health Perspectives 119(6), 748-756.

Related files

<mfanonymousfilelist></mfanonymousfilelist>

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