ERF of indoor dampness on respiratory health effects: Difference between revisions

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[[Category:Mega case study]]
[[Category:Mega case study]]
[[Category: CLAIH]]
[[Category: CLAIH]]
[[Category:Urgenche]]
[[Category:Contains R code]]
{{variable|moderator=Ulla H-S}}
{{variable|moderator=Ulla H-S}}
Exposure-response function of exposure to indoor dampness and/or mold or mold odor and respiratory health effects. The exposure-response function is expressed as ERF.


== Question ==
== Question ==
Line 13: Line 17:
== Answer ==
== Answer ==


'''Concentration-response function
'''Exposure-response function
 
<rcode graphics="1">
library(OpasnetUtils) # A package with Opasnet functionalities
library(xtable)      # A package with table formats
library(ggplot2)      # A package with fancy graph formats
 
objects.latest("Op_en4716", "calculations") # Get the latest ovariables from code calculations on page Op_en4716.


<t2b index="Disease,Response metric,Subjects,Exposure route,Exposure metric,Exposure unit,ERF parameter,Threshold,Observation" locations="ERF,Description" unit=" [[OR]] per yes/no visible dampness and/or mold or mold odor
ERF <- EvalOutput(ERF, N = 100)
">
Respiratory health effect|Upper respiratory tract symptoms|All|Inhalation|visible dampness and/or mold or mold odor|yes/no|OR|0|1.70|1.70 (1.44-2.00), No. studies: 13
Respiratory health effect|Cough|All|Inhalation|visible dampness and/or mold or mold odor|yes/no|OR|0|1.67|1.67 (1.49-1.86), No. studies: 18
Respiratory health effect|Cough|Adults|Inhalation|visible dampness and/or mold or mold odor|yes/no|OR|0|1.52|1.52 (1.18-1.96), No. studies: 6
Respiratory health effect|Cough|Children|Inhalation|visible dampness and/or mold or mold odor|yes/no|OR|0|1.75|1.75 (1.56-1.96), No. studies: 6
</t2b>


Page-specific entries (indices that have exactly one value each for the whole variable; usually mentioned in the title and/or in the scope.):
ERF@output <- data.frame(ERF@output, Pollutant = "Indoor.dampness") # This is needed because the Pollutant column is missing from the data table.
* Pollutant: visible dampness and/or mold or mold odor


print(xtable(ERF@output[ERF@output$Iter == 1 , ], digits = 4), type = 'html')


ggplot(ERF@output[ERF@output$ERF.parameter == "OR" , ], # Show a
aes(x = Disease, y = ERFResult)) + # , fill = Response.metric)) +
geom_boxplot() +
theme_grey(base_size = 24) +
theme(axis.text.x = element_text(angle = 90, hjust = 1))


</rcode>


== Definition ==
== Rationale==


=== Data ===
=== Data ===


{| {{prettytable}}
<t2b index="Disease,Response metric,Subjects,Exposure route,Exposure metric,Exposure unit,ERF parameter,Threshold,Observation" locations="Result,Description" unit=" OR per yes/no visible dampness and/or mold or mold odor
|+ '''Odds ratios for different health effects in homes with vs. without visible dampness and/or mold or mold odor.
">
<ref>W. J. Fisk, Q. Lei-Gomez, M. J. Mendell. Meta-analyses of the associations of respiratory health effects with dampness and mold in homes. Indoor Air 2007; 17: 284–296. {{doi|10.1111/j.1600-0668.2007.00475.x}}</ref> <ref>[http://ehp03.niehs.nih.gov/article/fetchArticle.action?articleURI=info%3Adoi%2F10.1289%2Fehp.1002410 Mendell et al. 2011. Respiratory and allergic health effects of dampness and mold, and dampness-related agents: a review of the epidemiological evidence. Environmental Health Perspectives 119(6), 748-756.]</ref>
Upper respiratory tract symptoms||All|Inhalation|visible dampness and/or mold or mold odor|yes/no|OR|0|1.70 (1.44-2.00)| No. studies: 13
!Outcome
Cough||All|Inhalation|visible dampness and/or mold or mold odor|yes/no|OR|0|1.67 (1.49-1.86)| No. studies: 18
! Subjects
Cough||Adults|Inhalation|visible dampness and/or mold or mold odor|yes/no|OR|0|1.52 (1.18-1.96)| No. studies: 6
! No. studies
Cough||Children|Inhalation|visible dampness and/or mold or mold odor|yes/no|OR|0|1.75 (1.56-1.96)| No. studies: 6
! Odds ratio central estimate (95 % CI)
Wheeze||All|Inhalation|visible dampness and/or mold or mold odor|yes/no|OR|0|1.50 (1.38-1.64)| No. studies: 22
! Estimated % increase in damp homes
Wheeze||Adults|Inhalation|visible dampness and/or mold or mold odor|yes/no|OR|0|1.39 (1.04-1.85)| No. studies: 5
|----
Wheeze||Children|Inhalation|visible dampness and/or mold or mold odor|yes/no|OR|0|1.53 (1.39-1.68)| No. studies: 17
| Upper respiratory tract symptoms || All || 13  || 1.70 (1.44–2.00) || 52
Current asthma||All|Inhalation|visible dampness and/or mold or mold odor|yes/no|OR|0|1.56 (1.30-1.86)| No. studies: 10
|----
Ever-diagnosed asthma||All|Inhalation|visible dampness and/or mold or mold odor|yes/no|OR|0|1.37 (1.23-1.53)| No. studies: 8
|rowspan="3" | Cough  || All  || 18  || 1.67 (1.49–1.86) || 50
Ever-diagnosed asthma||Children|Inhalation|visible dampness and/or mold or mold odor|yes/no|OR|0|1.35 (1.20-1.51)| No. studies: -
|----
Asthma development||All|Inhalation|visible dampness and/or mold or mold odor|yes/no|OR|0|1.34 (0.86-2.10)| No. studies: 4
| Adults || 6  || 1.52 (1.18–1.96) || –
Bronchitis||All|Inhalation|visible dampness and/or mold or mold odor|yes/no|OR|0|1.45 (1.32-1.59)| No. studies: -
|----
Bronchitis||Children|Inhalation|visible dampness and/or mold or mold odor|yes/no|OR|0|1.38 (1.28-1.47)| No. studies: -
| Children || 12  || 1.75 (1.56–1.96) || –
Respiratory infections||All|Inhalation|visible dampness and/or mold or mold odor|yes/no|OR|0|1.44 (1.31-1.59)| No. studies: -
|----
Respiratory infections||Adults|Inhalation|visible dampness and/or mold or mold odor|yes/no|OR|0|1.49 (1.14-1.95)| No. studies: -
| rowspan="3" |Wheeze  || All  || 22  || 1.50 (1.38–1.64) || 44
Respiratory infections||Children|Inhalation|visible dampness and/or mold or mold odor|yes/no|OR|0|1.48 (1.33-1.65)| No. studies: -
|----
Sensitivity to inhaled antigens||Children|Inhalation|visible dampness and/or mold or mold odor|yes/no|OR|0|1.33 (1.23-1.44)| No. studies: -
| Adults || 5  || 1.39 (1.04–1.85) || –
Hay fever||Children|Inhalation|visible dampness and/or mold or mold odor|yes/no|OR|0|1.35 (1.18-1.53)| No. studies: -
|----
</t2b>
| Children || 17  || 1.53 (1.39–1.68) || –
|----
| Current asthma || All || 10  || 1.56 (1.30–1.86) || 50
|----
| rowspan="2" |Ever-diagnosed asthma || All || 8  || 1.37 (1.23–1.53) || 33
|----
| Children ||   || 1.35 (1.20–1.51) ||
|----
| Asthma development || All || 4  || 1.34 (0.86–2.10) || 30
|----
| rowspan="2" |Bronchitis || All  ||   || 1.45 (1.32–1.59) ||  
|----
| Children ||   || 1.38 (1.28–1.47) ||
|----
| rowspan="3" |Respiratory infections || All ||   || 1.44 (1.31–1.59) ||  
|----
| Adults ||   || 1.49 (1.14–1.95) ||
|----
| Children ||   || 1.48 (1.33–1.65) ||
|----
| Sensitivity to inhaled antigens || Children || || 1.33 (1.23–1.44) ||
|----
| Hay fever || Children || || 1.35 (1.18–1.53) ||
|}


=== Dependencies ===
<ref>W. J. Fisk, Q. Lei-Gomez, M. J. Mendell. Meta-analyses of the associations of respiratory health e?ects with dampness and mold in homes. Indoor Air 2007; 17: 284–296. {{doi|10.1111/j.1600-0668.2007.00475.x}}</ref> <ref>[http://ehp03.niehs.nih.gov/article/fetchArticle.action?articleURI=info%3Adoi%2F10.1289%2Fehp.1002410 Mendell et al. 2011. Respiratory and allergic health effects of dampness and mold, and dampness-related agents: a review of the epidemiological evidence. Environmental Health Perspectives 119(6), 748-756.]</ref>


=== Unit ===
Page-specific entries (indices that have exactly one value each for the whole variable; usually mentioned in the title and/or in the scope.):
* Pollutant: visible dampness and/or mold or mold odor
* Threshold: 0
* Exposure metric: yes/no
* Exposure route: Inhalation


[[OR]] per yes/no visible dampness and/or mold or mold odor
===Unit===


=== Formula ===
[[OR]] for yes vs. no visible dampness and/or mold or mold odor


*Generates random samples of possible [[OR]]s.
=== Calculations ===
**Normal distribution assumed, sd estimated from confidence interval using sd = (upper bound - lower bound)/3.92


<nowiki>
<rcode label="Initiate variable" name="calculations">
n <- 10000
library(OpasnetUtils)
erf <- rnorm(n, 1.56, (1.86-1.30)/3.92)
library(xtable)
dim(erf) <- c(n, 1, 1)
dimnames(erf) <- list(obs=1:n, Outcome="Current asthma", "Age"="All")
erf <- as.data.frame(as.table(erf))</nowiki>


== Result ==
ERF <- Ovariable("ERF", ddata = "Op_en4716", getddata = FALSE, save = TRUE)


{{resultlink}}
cat("Ovariable ERF saved for later use. Page name: Op_en4716, code name: calculations\n")
 
print(xtable(EvalOutput(ERF, N = 1)@output), type = "html")
 
</rcode>


==See also==
==See also==
Line 107: Line 98:


==Keywords==
==Keywords==
Dampness and mould, ERF, Respiratory Disease, Asthma, Indoor Environment, Allergy


==References==
==References==

Latest revision as of 10:14, 26 August 2013



Exposure-response function of exposure to indoor dampness and/or mold or mold odor and respiratory health effects. The exposure-response function is expressed as ERF.

Question

What is the association between exposure to indoor dampness and mould in homes and respiratory health effects?

Answer

Exposure-response function

+ Show code

Rationale

Data

ERF of indoor dampness on respiratory health effects: Difference between revisions(OR per yes/no visible dampness and/or mold or mold odor)
ObsDiseaseResponse metricSubjectsExposure routeExposure metricExposure unitERF parameterThresholdResultDescription
1Upper respiratory tract symptomsAllInhalationvisible dampness and/or mold or mold odoryes/noOR01.70 (1.44-2.00) No. studies: 13
2CoughAllInhalationvisible dampness and/or mold or mold odoryes/noOR01.67 (1.49-1.86) No. studies: 18
3CoughAdultsInhalationvisible dampness and/or mold or mold odoryes/noOR01.52 (1.18-1.96) No. studies: 6
4CoughChildrenInhalationvisible dampness and/or mold or mold odoryes/noOR01.75 (1.56-1.96) No. studies: 6
5WheezeAllInhalationvisible dampness and/or mold or mold odoryes/noOR01.50 (1.38-1.64) No. studies: 22
6WheezeAdultsInhalationvisible dampness and/or mold or mold odoryes/noOR01.39 (1.04-1.85) No. studies: 5
7WheezeChildrenInhalationvisible dampness and/or mold or mold odoryes/noOR01.53 (1.39-1.68) No. studies: 17
8Current asthmaAllInhalationvisible dampness and/or mold or mold odoryes/noOR01.56 (1.30-1.86) No. studies: 10
9Ever-diagnosed asthmaAllInhalationvisible dampness and/or mold or mold odoryes/noOR01.37 (1.23-1.53) No. studies: 8
10Ever-diagnosed asthmaChildrenInhalationvisible dampness and/or mold or mold odoryes/noOR01.35 (1.20-1.51) No. studies: -
11Asthma developmentAllInhalationvisible dampness and/or mold or mold odoryes/noOR01.34 (0.86-2.10) No. studies: 4
12BronchitisAllInhalationvisible dampness and/or mold or mold odoryes/noOR01.45 (1.32-1.59) No. studies: -
13BronchitisChildrenInhalationvisible dampness and/or mold or mold odoryes/noOR01.38 (1.28-1.47) No. studies: -
14Respiratory infectionsAllInhalationvisible dampness and/or mold or mold odoryes/noOR01.44 (1.31-1.59) No. studies: -
15Respiratory infectionsAdultsInhalationvisible dampness and/or mold or mold odoryes/noOR01.49 (1.14-1.95) No. studies: -
16Respiratory infectionsChildrenInhalationvisible dampness and/or mold or mold odoryes/noOR01.48 (1.33-1.65) No. studies: -
17Sensitivity to inhaled antigensChildrenInhalationvisible dampness and/or mold or mold odoryes/noOR01.33 (1.23-1.44) No. studies: -
18Hay feverChildrenInhalationvisible dampness and/or mold or mold odoryes/noOR01.35 (1.18-1.53) No. studies: -

[1] [2]

Page-specific entries (indices that have exactly one value each for the whole variable; usually mentioned in the title and/or in the scope.):

  • Pollutant: visible dampness and/or mold or mold odor
  • Threshold: 0
  • Exposure metric: yes/no
  • Exposure route: Inhalation

Unit

OR for yes vs. no visible dampness and/or mold or mold odor

Calculations

+ Show code

See also

Keywords

Dampness and mould, ERF, Respiratory Disease, Asthma, Indoor Environment, Allergy

References

  1. ↑ W. J. Fisk, Q. Lei-Gomez, M. J. Mendell. Meta-analyses of the associations of respiratory health e?ects with dampness and mold in homes. Indoor Air 2007; 17: 284–296. doi:10.1111/j.1600-0668.2007.00475.x
  2. ↑ Mendell et al. 2011. Respiratory and allergic health effects of dampness and mold, and dampness-related agents: a review of the epidemiological evidence. Environmental Health Perspectives 119(6), 748-756.

Related files

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