ERF of indoor dampness on respiratory health effects: Difference between revisions

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[[Category:Mega case study]]
[[Category:Mega case study]]
[[Category: CLAIH]]
[[Category: CLAIH]]
[[Category:Urgenche]]
[[Category:Contains R code]]
{{variable|moderator=Ulla H-S}}
{{variable|moderator=Ulla H-S}}


== Scope ==
Exposure-response function of exposure to indoor dampness and/or mold or mold odor and respiratory health effects. The exposure-response function is expressed as ERF.
 
== Question ==


What is the association between exposure to indoor dampness and mould in homes and respiratory health effects?
What is the association between exposure to indoor dampness and mould in homes and respiratory health effects?


== Definition ==
== Answer ==
 
'''Exposure-response function
 
<rcode graphics="1">
library(OpasnetUtils) # A package with Opasnet functionalities
library(xtable)      # A package with table formats
library(ggplot2)      # A package with fancy graph formats
 
objects.latest("Op_en4716", "calculations") # Get the latest ovariables from code calculations on page Op_en4716.
 
ERF <- EvalOutput(ERF, N = 100)
 
ERF@output <- data.frame(ERF@output, Pollutant = "Indoor.dampness") # This is needed because the Pollutant column is missing from the data table.
 
print(xtable(ERF@output[ERF@output$Iter == 1 , ], digits = 4), type = 'html')
 
ggplot(ERF@output[ERF@output$ERF.parameter == "OR" , ], # Show a
aes(x = Disease, y = ERFResult)) + # , fill = Response.metric)) +
geom_boxplot() +
theme_grey(base_size = 24) +
theme(axis.text.x = element_text(angle = 90, hjust = 1))
 
</rcode>
 
== Rationale==


=== Data ===
=== Data ===


{| {{prettytable}}
<t2b index="Disease,Response metric,Subjects,Exposure route,Exposure metric,Exposure unit,ERF parameter,Threshold,Observation" locations="Result,Description" unit=" OR per yes/no visible dampness and/or mold or mold odor
|+ '''Odds ratios for different health effects in homes with vs. without visible dampness and/or mold or mold odor.
">
<ref>W. J. Fisk, Q. Lei-Gomez, M. J. Mendell. Meta-analyses of the associations of respiratory health effects with dampness and mold in homes. Indoor Air 2007; 17: 284–296. {{doi|10.1111/j.1600-0668.2007.00475.x}}</ref> <ref>[http://ehp03.niehs.nih.gov/article/fetchArticle.action?articleURI=info%3Adoi%2F10.1289%2Fehp.1002410 Mendell et al. 2011. Respiratory and allergic health effects of dampness and mold, and dampness-related agents: a review of the epidemiological evidence. Environmental Health Perspectives 119(6), 748-756.]</ref>
Upper respiratory tract symptoms||All|Inhalation|visible dampness and/or mold or mold odor|yes/no|OR|0|1.70 (1.44-2.00)| No. studies: 13
!Outcome
Cough||All|Inhalation|visible dampness and/or mold or mold odor|yes/no|OR|0|1.67 (1.49-1.86)| No. studies: 18
! Subjects
Cough||Adults|Inhalation|visible dampness and/or mold or mold odor|yes/no|OR|0|1.52 (1.18-1.96)| No. studies: 6
! No. studies
Cough||Children|Inhalation|visible dampness and/or mold or mold odor|yes/no|OR|0|1.75 (1.56-1.96)| No. studies: 6
! Odds ratio central estimate (95 % CI)
Wheeze||All|Inhalation|visible dampness and/or mold or mold odor|yes/no|OR|0|1.50 (1.38-1.64)| No. studies: 22
! Estimated % increase in damp homes
Wheeze||Adults|Inhalation|visible dampness and/or mold or mold odor|yes/no|OR|0|1.39 (1.04-1.85)| No. studies: 5
|----
Wheeze||Children|Inhalation|visible dampness and/or mold or mold odor|yes/no|OR|0|1.53 (1.39-1.68)| No. studies: 17
| Upper respiratory tract symptoms || All || 13  || 1.70 (1.44–2.00) || 52
Current asthma||All|Inhalation|visible dampness and/or mold or mold odor|yes/no|OR|0|1.56 (1.30-1.86)| No. studies: 10
|----
Ever-diagnosed asthma||All|Inhalation|visible dampness and/or mold or mold odor|yes/no|OR|0|1.37 (1.23-1.53)| No. studies: 8
|rowspan="3" | Cough  || All  || 18  || 1.67 (1.49–1.86) || 50
Ever-diagnosed asthma||Children|Inhalation|visible dampness and/or mold or mold odor|yes/no|OR|0|1.35 (1.20-1.51)| No. studies: -
|----
Asthma development||All|Inhalation|visible dampness and/or mold or mold odor|yes/no|OR|0|1.34 (0.86-2.10)| No. studies: 4
| Adults || 6  || 1.52 (1.18–1.96) || –
Bronchitis||All|Inhalation|visible dampness and/or mold or mold odor|yes/no|OR|0|1.45 (1.32-1.59)| No. studies: -
|----
Bronchitis||Children|Inhalation|visible dampness and/or mold or mold odor|yes/no|OR|0|1.38 (1.28-1.47)| No. studies: -
| Children || 12  || 1.75 (1.56–1.96) || –
Respiratory infections||All|Inhalation|visible dampness and/or mold or mold odor|yes/no|OR|0|1.44 (1.31-1.59)| No. studies: -
|----
Respiratory infections||Adults|Inhalation|visible dampness and/or mold or mold odor|yes/no|OR|0|1.49 (1.14-1.95)| No. studies: -
| rowspan="3" |Wheeze  || All  || 22  || 1.50 (1.38–1.64) || 44
Respiratory infections||Children|Inhalation|visible dampness and/or mold or mold odor|yes/no|OR|0|1.48 (1.33-1.65)| No. studies: -
|----
Sensitivity to inhaled antigens||Children|Inhalation|visible dampness and/or mold or mold odor|yes/no|OR|0|1.33 (1.23-1.44)| No. studies: -
| Adults || 5  || 1.39 (1.04–1.85) || –
Hay fever||Children|Inhalation|visible dampness and/or mold or mold odor|yes/no|OR|0|1.35 (1.18-1.53)| No. studies: -
|----
</t2b>
| Children || 17  || 1.53 (1.39–1.68) || –
 
|----
<ref>W. J. Fisk, Q. Lei-Gomez, M. J. Mendell. Meta-analyses of the associations of respiratory health e?ects with dampness and mold in homes. Indoor Air 2007; 17: 284–296. {{doi|10.1111/j.1600-0668.2007.00475.x}}</ref> <ref>[http://ehp03.niehs.nih.gov/article/fetchArticle.action?articleURI=info%3Adoi%2F10.1289%2Fehp.1002410 Mendell et al. 2011. Respiratory and allergic health effects of dampness and mold, and dampness-related agents: a review of the epidemiological evidence. Environmental Health Perspectives 119(6), 748-756.]</ref>
| Current asthma || All || 10  || 1.56 (1.30–1.86) || 50
|----
| rowspan="2" |Ever-diagnosed asthma || All || 8  || 1.37 (1.23–1.53) || 33
|----
| Children ||   || 1.35 (1.20–1.51) ||
|----
| Asthma development || All || 4  || 1.34 (0.86–2.10) || 30
|----
| rowspan="2" |Bronchitis || All  ||   || 1.45 (1.32–1.59) ||  
|----
| Children ||   || 1.38 (1.28–1.47) ||
|----
| rowspan="3" |Respiratory infections || All ||   || 1.44 (1.31–1.59) ||  
|----
| Adults ||   || 1.49 (1.14–1.95) ||
|----
| Children ||   || 1.48 (1.33–1.65) ||
|----
| Sensitivity to inhaled antigens || Children || || 1.33 (1.23–1.44) ||
|----
| Hay fever || Children || || 1.35 (1.18–1.53) ||
|}


=== Dependencies ===
Page-specific entries (indices that have exactly one value each for the whole variable; usually mentioned in the title and/or in the scope.):
* Pollutant: visible dampness and/or mold or mold odor
* Threshold: 0
* Exposure metric: yes/no
* Exposure route: Inhalation


=== Unit ===
===Unit===


[[OR]] per yes/no visible dampness and/or mold or mold odor
[[OR]] for yes vs. no visible dampness and/or mold or mold odor


=== Formula ===
=== Calculations ===


*Generates random samples of possible [[OR]]s.
<rcode label="Initiate variable" name="calculations">
**Normal distribution assumed, sd estimated from confidence interval using sd = (upper bound - lower bound)/3.92
library(OpasnetUtils)
library(xtable)


<nowiki>
ERF <- Ovariable("ERF", ddata = "Op_en4716", getddata = FALSE, save = TRUE)  
n <- 10000
erf <- rnorm(n, 1.56, (1.86-1.30)/3.92)
dim(erf) <- c(n, 1, 1)
dimnames(erf) <- list(obs=1:n, Outcome="Current asthma", "Age"="All")
erf <- as.data.frame(as.table(erf))</nowiki>


== Result ==
cat("Ovariable ERF saved for later use. Page name: Op_en4716, code name: calculations\n")


{{resultlink}}
print(xtable(EvalOutput(ERF, N = 1)@output), type = "html")
 
</rcode>


==See also==
==See also==
Line 89: Line 98:


==Keywords==
==Keywords==
Dampness and mould, ERF, Respiratory Disease, Asthma, Indoor Environment, Allergy


==References==
==References==

Latest revision as of 10:14, 26 August 2013



Exposure-response function of exposure to indoor dampness and/or mold or mold odor and respiratory health effects. The exposure-response function is expressed as ERF.

Question

What is the association between exposure to indoor dampness and mould in homes and respiratory health effects?

Answer

Exposure-response function

+ Show code

Rationale

Data

ERF of indoor dampness on respiratory health effects: Difference between revisions(OR per yes/no visible dampness and/or mold or mold odor)
ObsDiseaseResponse metricSubjectsExposure routeExposure metricExposure unitERF parameterThresholdResultDescription
1Upper respiratory tract symptomsAllInhalationvisible dampness and/or mold or mold odoryes/noOR01.70 (1.44-2.00) No. studies: 13
2CoughAllInhalationvisible dampness and/or mold or mold odoryes/noOR01.67 (1.49-1.86) No. studies: 18
3CoughAdultsInhalationvisible dampness and/or mold or mold odoryes/noOR01.52 (1.18-1.96) No. studies: 6
4CoughChildrenInhalationvisible dampness and/or mold or mold odoryes/noOR01.75 (1.56-1.96) No. studies: 6
5WheezeAllInhalationvisible dampness and/or mold or mold odoryes/noOR01.50 (1.38-1.64) No. studies: 22
6WheezeAdultsInhalationvisible dampness and/or mold or mold odoryes/noOR01.39 (1.04-1.85) No. studies: 5
7WheezeChildrenInhalationvisible dampness and/or mold or mold odoryes/noOR01.53 (1.39-1.68) No. studies: 17
8Current asthmaAllInhalationvisible dampness and/or mold or mold odoryes/noOR01.56 (1.30-1.86) No. studies: 10
9Ever-diagnosed asthmaAllInhalationvisible dampness and/or mold or mold odoryes/noOR01.37 (1.23-1.53) No. studies: 8
10Ever-diagnosed asthmaChildrenInhalationvisible dampness and/or mold or mold odoryes/noOR01.35 (1.20-1.51) No. studies: -
11Asthma developmentAllInhalationvisible dampness and/or mold or mold odoryes/noOR01.34 (0.86-2.10) No. studies: 4
12BronchitisAllInhalationvisible dampness and/or mold or mold odoryes/noOR01.45 (1.32-1.59) No. studies: -
13BronchitisChildrenInhalationvisible dampness and/or mold or mold odoryes/noOR01.38 (1.28-1.47) No. studies: -
14Respiratory infectionsAllInhalationvisible dampness and/or mold or mold odoryes/noOR01.44 (1.31-1.59) No. studies: -
15Respiratory infectionsAdultsInhalationvisible dampness and/or mold or mold odoryes/noOR01.49 (1.14-1.95) No. studies: -
16Respiratory infectionsChildrenInhalationvisible dampness and/or mold or mold odoryes/noOR01.48 (1.33-1.65) No. studies: -
17Sensitivity to inhaled antigensChildrenInhalationvisible dampness and/or mold or mold odoryes/noOR01.33 (1.23-1.44) No. studies: -
18Hay feverChildrenInhalationvisible dampness and/or mold or mold odoryes/noOR01.35 (1.18-1.53) No. studies: -

[1] [2]

Page-specific entries (indices that have exactly one value each for the whole variable; usually mentioned in the title and/or in the scope.):

  • Pollutant: visible dampness and/or mold or mold odor
  • Threshold: 0
  • Exposure metric: yes/no
  • Exposure route: Inhalation

Unit

OR for yes vs. no visible dampness and/or mold or mold odor

Calculations

+ Show code

See also

Keywords

Dampness and mould, ERF, Respiratory Disease, Asthma, Indoor Environment, Allergy

References

  1. ↑ W. J. Fisk, Q. Lei-Gomez, M. J. Mendell. Meta-analyses of the associations of respiratory health e?ects with dampness and mold in homes. Indoor Air 2007; 17: 284–296. doi:10.1111/j.1600-0668.2007.00475.x
  2. ↑ Mendell et al. 2011. Respiratory and allergic health effects of dampness and mold, and dampness-related agents: a review of the epidemiological evidence. Environmental Health Perspectives 119(6), 748-756.

Related files

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