INTERA: Di-methyl fumarate in consumer products

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Scope

Di-methyl fumarate concentrations in consumer products that are sold in Europe.

Definition

Data

According to the Hong Kong Trade Development Council (HKTDC) shoes, sofas and chair account for more than 90% of the total DMF products entered in EU (Hong Kong Trade Development Council, 2009). Other consumer products include toys and helmets (reported in the RAPEX database). A case of occupational exposure after contact with working trousers has also been reported (Foti et al. 2009).

The European RAPEX database provided 185 results (2005-2011) of products which were contaminated with DMF. These concentrations are measured just after the products have come to the marked and therefore are refereed as concentrations before exposure. Furthermore, some sutudies were found from the literature, which published measured concentrations from the consumer products after being suspected to cause exposure to DMF. These are referred as concentrations after exposure.

Unit

mg/kg

Result

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References

1. Gimenez-Arnau A. et al. 2009. Shoe contact dermatitis from dimethyl fumarate: clinical manifestations, patch test results, chemical analysis, and source of exposure, Contact Dermatitis 61:249–260.
2. Fraga A. et al. 2010. Allergic contact dermatitis to dimethyl fumarate in footwear, Contact Dermatitis 62:121–123.
3. Hasan T. et al. 2010. Persistent shoe dermatitis caused by dimethyl fumarate, Acta Dermato-Venereologica 90: 553-554
4. Retho C. Accessed 01-04-2011, Analysis of dimethylfumarate, European Commission meeting on 16 June 2009, http://ec.europa.eu/consumers/safety/projects/index_en.htm#dmf
5. Rantanen T. 2008. The cause of the Chinese sofa/chair dermatitis epidemic is likely to be contact allergy to dimethylfumarate, a novel potent contact sensitizer, British Journal of Dermatology 159:218–221.
6. ECHA 2010, Annex XV restriction report; proposal for a restriction of dimethyl fumarate, http://echa.europa.eu/doc/restrictions/annex_xv_restriction_report_DMFu_en.pdf
7. Davanzo F. et al. 2009. A case of contact dermatitis to dimethylfumarate in shoes identified in Italy, Annali dell'Istituto Superiore di Sanita 2010, 46:366-369.

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INTERA: Di-methyl fumarate in consumer products. Opasnet . [1]. Accessed 22 Dec 2024.