Renal Failure
| Moderator:Teemu R (see all) |
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Scope
What is the prevalence of renal failure in the general population?
Definition
| Rate (age, sex ratio) | Context (population size studied, location, date data taken, end-point measured) | Definition of end-point | Reference |
|---|---|---|---|
| 49% males <55 = 1.1% men & 7.9% women 55-65 = 7.1% men & 23.5% women >65 = 12.9% men & 35.9% women |
n=6317, Switzerland, 2001-2003, stage 3 renal impairment in adults | eGFR of <60 ml/min/1.73m2 | Prevalence of renal impairment and its association with cardiovascular risk factors in a general population: [1] |
| 36.3% males >55 = 51.7% |
n=4484, Rotterdam (Netherlands), baseline data 1990-1993, follow up 2002, mild renal dysfunction | eGFR between 60 and 89 mL/min/1.73m2 | Renal function and risk of myocardial infarction in an elderly population [2] |
| 28-75yrs = 16.6% (Creatinine clearance < 60mL/min/1.73m2 was present in 5.0% and microalbuminuria in 12.9% of the total population) |
n=8592, Groningen (Netherlands), 1997-1998, mild renal dysfunction | creatinine clearance <60 mL/min/1.73m2 and /or microalbuminuria (30-300mg/24h). | Mild renal dysfunction is associated with electrocardiographic left ventricular hypertrophy [3] |
| 20yrs+ (46.8% men) Mildly decreased=38.6% moderately decreased=4.5%, severely decreased=0.2% |
n=65 181, Nord-Trondelag County (Norway), 1995-1997, prevalence of chronic kidney disease | mildly impaired = eGFR 60 to 89 moderately impaired = eGFR 30 to 59 severely impaired = eGFR 15 to 29 ml/min per 1.73 m2 | International comparison of the relationship of chronic kidney disease prevalence and ESRD risk [4] |
| The median prevalence of CKD was 7.2% in persons aged 30 years or older. In persons aged 64 years or older prevalence of CKD varied from 23.4% to 35.8%. | Worldwide, Prevalence of Chronic Kidney Disease, | Standardized definition from the Kidney Disease Outcomes Quality Initiative of the National Kidney Foundation (K/DOQI) practice guideline - CrCl or GFR less than 60 ml/min/1.73 m2 |
Zhang et al. Prevalence of chronic kidney disease in population-based studies: systematic review [5] |
| 209 cases per million population (95% CI 195 to 223). | Madrid (Spain), acute renal failure (ARF) | Sudden rise in serum creatinine concentration (SCr) to more than 177 mumol/liter in patients with normal renal function. Sudden rise (50% or more) in patients with previous mild-to-moderate chronic renal failure (SCr < 264 mumol/liter). |
Liaño F, Pascual J. Epidemiology of acute renal failure: a prospective, multicenter, community-based study. Madrid Acute Renal Failure Study Group. Kidney Int. 1996 Sep; 50(3):811-8. |
| 20yrs+ (mean age 49.58) (42.6% males) Grade 3 CKD = 5.1% Coexistence of an albumin/creatinine ratio>30 mg/g with grade 1 to 2 CKD = 12.7% |
n=237, Galicia (Spain), 2004, grade 3 CKD | Grade 3 CKD eGFR 30 to 59 ml/min per 1.73 m2 Grade 2 CKD eGFR 60 to 89 ml/min per 1.73 m2 Grade 1 CKD eGFR >90 ml/min per 1.73 m2 |
Otero A, Gayoso P, Garcia F, de Francisco AL; EPIRCE study group. Epidemiology of chronic renal disease in the Galician population: results of the pilot Spanish EPIRCE study. Kidney Int Suppl. 2005 Dec;(99):S16-9. |
| All ages (?) stages 3-5 = 6.9% eGFR 60-89 = 13.5% eGFR >90 = 3.1% |
n=162 113, Surrey, Kent and Greater Manchester (UK), 2003-2004, CKD | CKD stages 3-5 eGFR = < 60 ml/min per 1.73 m2 | New JP, Middleton RJ, Klebe B, Farmer CK, de Lusignan S, Stevens PE, O'Donoghue DJ. Assessing the prevalence, monitoring and management of chronic kidney disease in patients with diabetes compared with those without diabetes in general practice. Diabet Med. 2007 Apr;24(4):364-9. Epub 2007 Feb 28. |
| 28-75 yrs 7.2% |
n=40 856, Groningen (Netherlands), microalbuminuria | Microalbuminuria (20-200 mg L-1) | Hillege HL, Janssen WM, Bak AA, Diercks GF, Grobbee DE, Crijns HJ, Van Gilst WH, De Zeeuw D, De Jong PE; PREVEND Study Group. Microalbuminuria is common, also in a nondiabetic, nonhypertensive population, and an independent indicator of cardiovascular risk factors and cardiovascular morbidity. J Intern Med. 2001 Jun;249(6):519-26. |
| 14-96yrs (mean age at presentation 76yrs) 486 per million population/year |
n=288, East Kent (UK), Acute renal failure (ARF) | creatinine 300 µmol/l or urea >40 mmol/l (in patients with baseline creatinine <250 µmol/l). | P.E. Stevens, N.A. Tamimi, M.K. Al-Hasani, A.I. Mikhail, E. Kearney, R. Lapworth, D.I. Prosser and P. Carmichael. Non-specialist management of acute renal failure. Q J Med 2001; 94: 533-540 |
| 15 yrs + 286 per million of the adult population/year |
n=809, Scotland, 2002, Acute renal failure (group A) and acute on chronic kidney disease (group B) | Defined as patients starting renal replacement therapy. When starting RRT, the median values (range) of serum creatinine concentration and urea were 373(49–2374) and 512 (68–1747) mmol/l and 26 (4–94) and 36 (9–110) mmol/l, for groups A and B, respectively. | Gordon J. Prescott, Wendy Metcalfe, Jyoti Baharani, Izhar H. Khan, Keith Simpson, W. Cairns S. Smith and Alison M. MacLeod. A prospective national study of acute renal failure treated with RRT: incidence, aetiology and outcomes. Nephrol Dial Transplant (2007). |
Result
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