Osteoporosis

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Scope

What is the prevalence of osteoporosis in the general population?

Definition

Spain: ~2 million women with osteoporosis; prevalent in 26.1% of women 50+	Contains information on fractures and prevalence of osteoporosis across Europe with references for each of the facts		International Osteoporosis Foundation http://www.iofbonehealth.org/facts-and-statistics.html
7.8 million affected (6.5 million women)	Germany, 2003	Claims data for patients with osteoporosis (M80, M81) or an osteoporosis-related fracture diagnosis (S22, S32, S42, S52, S72, S82) or treatment with anti-osteoporosis drugs	Epidemiology, treatment and costs of osteoporosis in Germany – the BoneEVA Study; Osteoporosis Int. 2007 v.18(1):77-84
40.8% in women >50 and 17.7% in men >50	Denmark, 1995-1999	Based on normal Danish values for BMD, the expected number of subjects aged 50 years + with osteoporosis according to the WHO definition was calculated	Osteoporosis is markedly underdiagnosed: a nationwide study from Denmark; Osteoporos Int. 2005 Feb;16(2):134-41.
Women, 45-59yrs 5.0% had a BMD <2.5 SD of the mean premenopausal reference value and were thus considered to be osteoporotic. Patients were classified as slow (41.7%), borderline (28.2%), and fast (30.1%) bone losers. By integrating the estimated annual percent bone loss with baseline bone mineral content, 27.6% of the postmenopausal women were identified as at risk of developing osteoporosis at age 65 years.	n=2286, Italy, risk of osteoporosis	Risk of osteoporosis by combining a baseline distal forearm bone mineral content measurement with an estimation of annual percent bone loss as shown by plasma bone Gla protein, serum alkaline phosphatase, and fasting urinary creatinine-corrected calcium and hydroxyproline	AGNUSDEI D. CALCAGNO V. CHRISTIANSEN C. CREPALDI G. GENNARI C. MARTINI L. MAZZUOLI G. F. PASQUARELLI V. Prevalence of osteoporosis and prediction of osteoporosis risk in Italian peri- and postmenopausal women : The detection of osteoporosis risk (door) study. Current therapeutic research 1996, vol. 57, no2, pp. 110-122.
Prevalence of osteoporosis at the age intervals shown in Sweden using female-derived reference ranges at the femoral neck. (Reprinted from [24) Men Women Age range %of Number %of Number (years) population affected (000) population affected (000) 50–54 2.5 7.0 6.3 17.0 55–59 3.5 7.6 9.6 21.1 60–64 5.8 11.4 14.3 30.0 65–69 7.4 14.2 20.2 43.7 70–74 7.8 14.6 27.9 63.0 75–79 10.3 13.7 37.5 68.3 80–84 16.6 14.7 47.2 67.8 50–80 6.3 83.2 21.2 310.9	Sweden, osteoporosis, paper contains other tables and data	WHO criteria	J. A. Kanis, N. Burlet, C. Cooper, P. D. Delmas, J.-Y. Reginster, F. Borgstrom, R. Rizzoli and on behalf of the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO). European guidance for the diagnosis and management of osteoporosis in postmenopausal women. Journal Osteoporosis International, Volume 19, Number 4 / April, 2008

Result

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