ERF of waterborne microbes: Difference between revisions
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=== Calculations === | === Calculations === | ||
<rcode name="ERF_micr2" label="Initiate ovariable ERF_micr" embed=1> | |||
# This is code Op_en7948/ERF_micr2 on page [[ERF of waterborne microbes]] | |||
# Note! This version has ERF and threshold in the same ovariable. | |||
library(OpasnetUtils) | |||
ERF_micr <- Ovariable("ERF_micr", ddata = "Op_en7948") | |||
colnames(ERF_micr@data) <- gsub(" ", "_", colnames(ERF_micr@data)) | |||
objects.store(ERF_micr) | |||
cat("Ovariable ERF_micr stored.\n") | |||
</rcode> | |||
<rcode name="ERF_micr" label="Initiate ovariables ERF_micr, threshold_micr" embed=1> | <rcode name="ERF_micr" label="Initiate ovariables ERF_micr, threshold_micr" embed=1> | ||
Revision as of 07:33, 12 July 2019
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Question
What are the dose-response functions of pathogens in drinking water?
Answer
Rationale
Data
| Obs | Exposure agent | Response | Exposure | Exposure unit | ER function | Scaling | Threshold | ERF | Description |
|---|---|---|---|---|---|---|---|---|---|
| 1 | campylobacter | campylobacter infection | ingestion | ? | beta poisson approximation | None | 0.011 | 0.024 | |
| 2 | rotavirus | rotavirus infection | ingestion | ? | exact beta poisson | None | 0.191 | 0.167 | |
| 3 | norovirus | norovirus infection | ingestion | ? | exact beta poisson | None | 0.055 | 0.04 | |
| 4 | cryptosporidium | cryptosporidium infection | ingestion | ? | exact beta poisson | None | 0.176 | 0.115 | |
| 5 | giardia | giardia infection | ingestion | ? | exponential | None | 0 | 0.0199 | |
| 6 | E.coli | E. coli infection | ingestion | ? | exact beta poisson | None | 9.16 | 0.157 | E. coli O157:H7 strain |
⇤--arg6688: . Find out the units of the parameters to understand the functions precisely. --Jouni (talk) 12:54, 11 July 2019 (UTC) (type: truth; paradigms: science: attack)
In these equations, Param1 and Param2 are in Threshold and ERF columns, respectively.
- Beta Poisson approximation: 1-(1+Dose/Param2)^-Param1
- Exact beta Poisson: 1-exp(-(Param1/(Param1+Param2))*Dose)
- Exponential: 1-exp(-Param1*Dose)
| Pathogen | Reference |
| Campylobacter | [1] |
| Rotavirus | [2] |
| Norovirus | [3] |
| Cryptosporidium | [4] |
| Giardia | [5] |
| E.coli O157:H7 | [6] |
Calculations
⇤--arg5268: . The code below is old and does not work with the new ERF table. --Jouni (talk) 12:54, 11 July 2019 (UTC) (type: truth; paradigms: science: attack)
See also
References
- ↑ Campylobacter (Teunis et al. 2005) Exact Beta-Poisson model Low Dose Approximation:Dose Response relationship for Campylobacter from model fit results presented by Teunis et al. (2005) Epidemiol. Infec. 133, 583-592.
- ↑ Teunis, P. F. M. and Havelaar, A. (2000). "The beta Poisson dose‐response model is not a single hit model."Risk Analysis 20(4): 511‐518.
- ↑ Teunis et al. 2008 Norwalk Virus: How Infectious is It? Journal of Medical Virology 80:1468-1476.
- ↑ Teunis et al., 2002 Risk Analysis 22(1) 175-183
- ↑ Teunis et al., 1996 RIVM report No. 284550002 " The dose-response relation in human volunteers for gastro-intestinal pathogens"
- ↑ Teunis, P., Takumi, K. and Shinagawa, K. (2004). "Dose response for infection by Escherichia coli O157:H7 from outbreak data." Risk Analysis 24(2): 401‐407.
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