ERF for Frambozadrine in rats: Difference between revisions
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'''Scope'''<br> | '''Scope'''<br> | ||
'''[[Frambozadrine]] dose-response function in rats''' describes the long-term health impact(s) caused by [[frambozadrine]] as a function of dose in rats. This dose-response function applies only to continuous long-term exposures of [[frambozadrine]] (like in chronic studies). | '''[[Frambozadrine]] dose-response function in rats''' describes the long-term health impact(s) caused by [[frambozadrine]] as a function of dose in rats. This [[Variable:Generalized dose-response function|dose-response function]] applies only to continuous long-term exposures of [[frambozadrine]] (like in chronic studies). | ||
[[Category:Health effects]] | [[Category:Health effects]] | ||
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====Plausible dose-response functions==== | ====Plausible dose-response functions==== | ||
*[[Variable:Generalized dose-response function|Generalized dose-response function]] | |||
*[[Multistage model]] (first order) | *[[Multistage model]] (first order) | ||
*[[Multistage model]] (second order) | *[[Multistage model]] (second order) | ||
Revision as of 10:50, 24 October 2007
Scope
Frambozadrine dose-response function in rats describes the long-term health impact(s) caused by frambozadrine as a function of dose in rats. This dose-response function applies only to continuous long-term exposures of frambozadrine (like in chronic studies).
Definition
Causality
Upstream variables not defined.
Data
Toxicological data about frambozadrine in rats.
| Dose(mg/kg-day) | Total no rats | Hyperkeratosis |
|---|---|---|
| Male | ||
| 0 | 47 | 2 |
| 1.2 | 45 | 6 |
| 15 | 44 | 4 |
| 82 | 47 | 24 |
| Female | ||
| 0 | 48 | 3 |
| 1.8 | 49 | 5 |
| 21 | 47 | 3 |
| 109 | 48 | 33 |
Plausible dose-response functions
- Generalized dose-response function
- Multistage model (first order)
- Multistage model (second order)
- Weibull model
Formula
Methods for estimating dose-responses
- Bootstrap method
- Probabilistic inversion
- Non-parametric Bayesian estimation
- Bayesian model averaging
Unit
probability of impact