IRIS: Difference between revisions

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  http://www.epa.gov/iris/toxreviews/0128tr.pdf (this does not exist for many compounds)
  http://www.epa.gov/iris/toxreviews/0128tr.pdf (this does not exist for many compounds)


===Oral RfDs===
{{defend|# |Tämähän alkaa olla oikein hyvä! Alla vielä muutamia kommentteja.|--[[User:Jouni|Jouni]] 20:34, 28 June 2012 (EEST)}}


Oral RfDs were scrapped as an example (chemical starting with A) on Jan 4, 2012.
* Tulokset on tässä kirjoitettu muotoon 3.4x10-3. Joko interpret-funktiota on päivitettävä siten, että se ymmärtää tämän, tai sitten kaikki näiden taulukoiden tulokset pitää muuttaa muotoon 3.4e-3 (jonka R ymmärtää oikein, kun käytetään as.numericia). Tuntuu, että interpretin päivitys olisi parempi vaihtoehto.
* Yksiköt pitäisi muuttaa tietokoneelle ymmärrettäväksi. Vaihtoehtoja: a) [[Unit conversions]] -sivulle lisätään kaikki tässä esiintyvät uudet yksiköt, niin että niille saadaan muunnosohjeet (esim. mg /kg-day &rarr; mg /kg /d tai per µg /m<sup>3</sup> &rarr; m3 /µg. b) Kaikki yksiköt tällä sivulla muutetaan tuohon standardimuotoon. Mikä tuntuisi järkevältä?
 
 
{{attack|# |Jos jossakin taulukossa joka rivillä on sama yksikkö, koko saraketta ei tarvita vaan riittää yksikön ilmoittaminen osoiterivillä.|--[[User:Jouni|Jouni]] 20:34, 28 June 2012 (EEST)}}


{{attack|# |Ei tätä kannata tehdä rivi kerrallaan, vaan ottaa koko viiden taulukon tiedosto (ks. Related files) muokata siitä tekstinkäsittelyohjelmalla viisi t2b-taulukkoa. Etsi-korvaa-toiminnolla voi tehdä suurimman osan muotoiluista. Kannattaa kysyä apua jos ei osaa, koska muuten työssä menee päiviä.|--[[User:Jouni|Jouni]] 10:42, 20 June 2012 (EEST)}}
{{attack|# |Ei tätä kannata tehdä rivi kerrallaan, vaan ottaa koko viiden taulukon tiedosto (ks. Related files) muokata siitä tekstinkäsittelyohjelmalla viisi t2b-taulukkoa. Etsi-korvaa-toiminnolla voi tehdä suurimman osan muotoiluista. Kannattaa kysyä apua jos ei osaa, koska muuten työssä menee päiviä.|--[[User:Jouni|Jouni]] 10:42, 20 June 2012 (EEST)}}
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|3 = --[[User:Jouni|Jouni]] 10:42, 20 June 2012 (EEST)}}
|3 = --[[User:Jouni|Jouni]] 10:42, 20 June 2012 (EEST)}}


<t2b index = "Substance,Observation type" locations = "CASRN,Critical Effact(s),Unit,Oral RfD,Type of RfD,Point of Departure(s)*,Overall Confidence,IRIS identifier" unit = "mg /kg-day">
==See also==
Acenaphthene|83-32-9| Hepatotoxicity|mg /kg-day|6 x10-2|NOAEL|175|Low|0442
Acenaphthylene|208-96-8|Not Assessed under the IRIS program||||||0443
Acephate|30560-19-1|Inhibition of brain ChE|mg /kg-day|4 x10-3|LEL|0.12|High|0354
Acetaldehyde|75-07-0|Not Assessed under the IRIS program||||||0290
Acetochlor|34256-82-1|Salivation, increased ALT and ornithine carbamyl transferase; significant increases in triglyceride and decreased blood glucose levels; histopathological changes in kidneys and testes of males|mg /kg-day|2 x10-2|NOAEL|2 mg/kg-day|High|0521
Acetone|67-64-1|Nephropathy|mg /kg-day|0.9|NOAEL|900|Medium|0128
Acetonitrile|75-05-8|Information reviewed but value not estimated. Refer to IRIS Summary.||||||0205
Acetophenone|98-86-2|General toxicity|mg /kg-day|1 x10-1|NOAEL|423|Low|0321
Acetyl chloride|75-36-5|Not Assessed under the IRIS program||||||0518
Acifluorfen, sodium|62476-59-9|Mortality and kidney lesions|mg /kg-day|1.3 x10-2|NOEL|1.25|Medium|0192
Acrolein|107-02-8|Decreased survival|mg /kg-day|5 x10-4|NOAEL|0.05|Medium/High|0364
Acrylamide|79-06-1|Degenerative nerve changes|mg /kg-day|0.002|HED (BMDL)|0.053|Medium/High|0286
Acrylic acid|79-10-7|Reduced pup weight|mg /kg-day|5 x10-1|NOAEL|53|High|0002
Acrylonitrile|107-13-1|Not Assessed under the IRIS program||||||0206
Adiponitrile|111-69-3|Not Assessed under the IRIS program||||||0515
Alachlor|15972-60-8|Hemosiderosis, hemolytic anemia|mg /kg-day|1 x10-2|NOAEL|1|High|0129
Alar|1596-84-5|No adverse effects|mg /kg-day|1.5 x10-1|NOEL|15|Low|0287
Aldicarb|116-06-3|Sweating as clinical sign of AChe inhibition (other effect: Clinical signs and symptoms of acetylcholinesterase inhibition including sweating, pinpoint pupils, leg weakness, and other effects Nausea, diarrhea, and other signs and symptoms)|mg /kg-day|1 x10-3|NOAEL|0.01|Medium|0003
Aldicarb sulfone|1646-88-4|Brain ChE inhibition in females|mg /kg-day|1 x10-3|NOAEL|0.11|Medium|0312
Aldrin|309-00-2|Liver toxicity|mg /kg-day|3 x10-5|LOAEL|0.025|Medium|0130
Ally|74223-64-6|Decreased body weight|mg /kg-day|2.5 x10-1|NOEL|25|High|0288
Allyl alcohol|107-18-6|Impaired renal function and increased liver and kidney weights|mg /kg-day|5 x10-3|NOEL|4.8|Low|0004
Allyl chloride|107-05-1|Not Assessed under the IRIS program||||||0387
Aluminum phosphide|20859-73-8|Body weight and clinical parameters|mg /kg-day|4 x10-4|NOAEL|0.043|Medium|0005
Amdro|67485-29-4|Increased organ weights|mg /kg-day|3 x10-4|NOEL|0.33|High|0207
Ametryn|834-12-8|Liver toxicity|mg /kg-day|9 x10-3|NOEL|8.6|Low|0208
4-Aminopyridine|504-24-5|Not Assessed under the IRIS program||||||0440
Amitraz|33089-61-1|Increased mean blood sugar concentration; slight hypothermia|mg /kg-day|2.5 x10-3|NOEL|0.25|Medium|0334
Ammonia|7664-41-7|Not Assessed under the IRIS program||||||0422
Ammonium acetate|631-61-8|Not Assessed under the IRIS program||||||0517
Ammonium methacrylate|16325-47-6|Not Assessed under the IRIS program||||||0516
Ammonium sulfamate|7773-06-0|Decrease in body weight|mg /kg-day|2 x10-1|NOEL|214.3|Low|0007
Aniline|62-53-3|Not Assessed under the IRIS program||||||0350
ortho-Anisidine|90-04-0|Not Assessed under the IRIS program||||||0610
Anthracene|120-12-7|No observed effects|mg /kg-day|3 x10-1|NOEL|1000|Low|0434
Antimony|7440-36-0|Longevity, blood glucose, and cholesterol|mg /kg-day|4 x10-4|LOAEL|0.35|Low|0006
Antimony trioxide|1309-64-4|Not Assessed under the IRIS program||||||0676
Apollo|74115-24-5|Liver effects; organ weight changes|mg /kg-day|1.3 x10-2|NOEL|1.25|High|0008
Aramite|140-57-8|Not Assessed under the IRIS program||||||0473
Aroclor 1016|12674-11-2|Reduced birth weights|mg /kg-day|7 x10-5|NOAEL|0.007|Medium|0462
Aroclor 1248|12672-29-6|Information reviewed but value not estimated. Refer to IRIS Summary.||||||0649
Aroclor 1254|11097-69-1|Ocular exudate, inflamed and prominent Meibomian glands, distorted growth of finger and toe nails; decreased antibody (IgG and IgM) response to sheep erythrocytes|mg /kg-day|2 x10-5|LOAEL|0.005|Medium|0389
Arsenic, inorganic|7440-38-2|Hyperpigmentation, keratosis and possible vascular complications|mg /kg-day|3 x10-4|NOAEL|0.0008|Medium|0278
Arsine|7784-42-1|Not Assessed under the IRIS program||||||0672
Asbestos|1332-21-4|Not Assessed under the IRIS program||||||0371
Assure|76578-14-8|Liver cell enlargement|mg /kg-day|9 x10-3|NOEL|0.9|High|0335
Asulam|3337-71-1|Lower ovarian weight, lower liver/body weight|mg /kg-day|5 x10-2|LEL|50|Medium|0284
Atrazine|1912-24-9|Decreased body weight gain (other effect: Cardiac toxicity and moderate-to-severe dilation of the right atrium)|mg /kg-day|3.5 x10-2|NOAEL|3.5|High|0209
Avermectin B1|65195-55-3|Increased retinal folds in weanlings, decreased viability and lactation indices, decreased pup body weight, increase of dead pups at birth|mg /kg-day|4 x10-4|NOEL|0.12|High|0381
Azobenzene|103-33-3|Not Assessed under the IRIS program||||||0351
Barium and Compounds|7440-39-3|Nephropathy|mg /kg-day|0.2|BMDL05|63|Medium|0010
Barium cyanide|542-62-1|Information reviewed but value not estimated. Refer to IRIS Summary.||||||0009
Baygon|114-26-1|Mild cholinergic symptoms and RBD ChE inhibition|mg /kg-day|4 x10-3|LEL|0.36|Medium|0210
Bayleton|43121-43-3|Decreased body weight gain, erythrocyte count and hemoglobin level|mg /kg-day|3 x10-2|NOEL|2.5|High|0131
Baythroid|68359-37-5|Decreased body weights in males, inflammatory foci in kidneys of females|mg /kg-day|2.5 x10-2|NOEL|2.5|High|0132
Benefin|1861-40-1|Depressed erythrocyte counts|mg /kg-day|3 x10-1|NOAEL|25|Medium|0133
Benomyl|17804-35-2|Decreased pup weanling weights|mg /kg-day|5 x10-2|NOEL|5 mg/kg-day|High|0011
Bentazon (Basagran)|25057-89-0|Blood loss into the gastrointestinal tract; coagulation defect in male and female dogs (other effect: Dose-related increase in red areas (presumed blood) in feces; coagulation defect)|mg /kg-day|3.0 x10-2|NOAEL (ADJ)|3.2|Medium|0134
Benz[a]anthracene|56-55-3|Not Assessed under the IRIS program||||||0454
Benzaldehyde|100-52-7|Forestomach lesions, kidney toxicity|mg /kg-day|1 x10-1|NOEL|143|Low|0332
Benzene|71-43-2|Decreased lymphocyte count|mg /kg-day|4.0 x10-3|BMDL|1.2|Medium|0276
Benzidine|92-87-5|Brain cell vacuolization; liver cell alterations in females|mg /kg-day|3 x10-3|LOAEL|2.7|Medium|0135
</t2b>
 
===Inhalation RfCs===


<t2b index = "Substance,Observation type" locations = "CASRN,Critical Effact(s),Unit,Inhalation RfC,Type of RfC,Point of Departure(s)*,Overall Confidence,IRIS identifier" unit = "mg /m<sup>3</sup>">
* [[IRIS/Oral RfDs]]
Acenaphthene|83-32-9|Not Assessed under the IRIS program.||||||
* [[IRIS/Inhalation RfCs]]
Acenaphthylene|208-96-8|Not Assessed under the IRIS program.||||||
* [[IRIS/Weight-of-Evidence Characterizations]]
Acephate|30560-19-1|Not Assessed under the IRIS program.||||||
* [[IRIS/Inhalation unit risks]]
Acetaldehyde|75-07-0|Degeneration of olfactory epithelium|mg /m<sup>3</sup>|9x10<sup>-3</sup>|NOAEL (HEC)|8.7|Low|0290
* [[Template:IRIS links]]
Acetochlor|34256-82-1|Not Assessed under the IRIS program.||||||
Acetone|67-64-1|Not Assessed under the IRIS program.||||||
Acetonitrile|75-05-8|Not Assessed under the IRIS program.||||||
Acetophenone|98-86-2|Mortality|mg /m<sup>3</sup>|6x10<sup>-2</sup>|NOAEL (HEC)|60|Medium|0205
Acetyl chloride||Not Assessed under the IRIS program.||||||
Acifluorfen, sodium||Not Assessed under the IRIS program.||||||
Acrolein||Nasal lesions|mg /m<sup>3</sup>|2x10<sup>-5</sup>|LOAEL (HEC)|0.02|Medium|0364
Acrylamide||Degenerative nerve changes|mg /m<sup>3</sup>|0.006|HEC (BMDL)|0.18|Medium|0286
Acrylic acid||Degeneration of the nasal olfactory epithelium|mg /m<sup>3</sup>|1x10<sup>-3</sup>|LOAEL (HEC)|0.33|Medium|0002
Acrylonitrile||Degeneration and inflammation of nasal respiratory epithelium; hyperplasia of mucous secreting cells|mg /m<sup>3</sup>|2x10<sup>-3</sup>|LOAEL (HEC)|1.9|Medium|0206
Adiponitrile||Not Assessed under the IRIS program.||||||
Alachlor||Not Assessed under the IRIS program.||||||
Alar||Not Assessed under the IRIS program.||||||
Aldicarb||Not Assessed under the IRIS program.||||||
Aldicarb sulfone||Not Assessed under the IRIS program.||||||
Aldrin||Not Assessed under the IRIS program.||||||
Ally||Not Assessed under the IRIS program.||||||
Allyl alcohol||Not Assessed under the IRIS program.||||||
Allyl chloride||Functional and histological peripheral neurotoxicity|mg /m<sup>3</sup>|1x10<sup>-3</sup>|NOAEL (HEC)|3.6|Low|0387
Aluminum phosphide||Not Assessed under the IRIS program.||||||
Amdro||Not Assessed under the IRIS program.||||||
Ametryn||Not Assessed under the IRIS program.||||||
4-Aminopyridine||Not Assessed under the IRIS program.||||||
Amitraz||Not Assessed under the IRIS program.||||||
Ammonia||Not Assessed under the IRIS program.||||||
Ammonium acetate||Not Assessed under the IRIS program.||||||
Ammonium methacrylate||Not Assessed under the IRIS program.||||||
Ammonium sulfamate||Not Assessed under the IRIS program.||||||
Aniline|62-53-3|Lack of toxicity (other effect: Mild spleen toxicity )|mg /m<sup>3</sup>|1x10<sup>-3</sup>|NOAEL (HEC)|3.4|Low|0350
ortho-Anisidine|90-04-0|Information reviewed but value not estimated. Refer to IRIS Summary.||||||0610
Anthracene||Not Assessed under the IRIS program.||||||
Antimony||Not Assessed under the IRIS program.||||||
Antimony trioxide|1309-64-4|Pulmonary toxicity, chronic interstitial inflammation|mg /m<sup>3</sup>|2x10<sup>-4</sup>|BMC<sub>10</sub> (HEC)|0.074|Medium|0676
Apollo||Not Assessed under the IRIS program.||||||
Aramite||Not Assessed under the IRIS program.||||||
Aroclor 1016||Not Assessed under the IRIS program.||||||
Aroclor 1248||Not Assessed under the IRIS program.||||||
Aroclor 1254||Not Assessed under the IRIS program.||||||
Arsenic, inorganic||Not Assessed under the IRIS program.||||||
Arsine|7784-42-1|Increased hemolysis, abnormal RBC morphology, and increased spleen weight (other effect: Increased hemolysis, increased spleen weight, and impaired compensatory erythropoiesis)|mg /m<sup>3</sup>|5x10<sup>-5</sup>|NOAEL (HEC)|0.014|Medium|0672
Asbestos||Not Assessed under the IRIS program.||||||
Assure||Not Assessed under the IRIS program.||||||
Asulam||Not Assessed under the IRIS program.||||||
Atrazine||Not Assessed under the IRIS program.||||||
Avermectin B1||Not Assessed under the IRIS program.||||||
Azobenzene||Not Assessed under the IRIS program.||||||
Barium and Compounds||Not Assessed under the IRIS program.||||||
Barium cyanide||Not Assessed under the IRIS program.||||||
Baygon||Not Assessed under the IRIS program.||||||
Bayleton||Not Assessed under the IRIS program.||||||
Baythroid||Not Assessed under the IRIS program.||||||
Benefin||Not Assessed under the IRIS program.||||||
Benomyl||Not Assessed under the IRIS program.||||||
Bentazon (Basagran)||Not Assessed under the IRIS program.||||||
Benz[a]anthracene||Not Assessed under the IRIS program.||||||
Benzaldehyde||Not Assessed under the IRIS program.||||||
Benzene|71-43-2|Decreased lymphocyte count|mg /m<sup>3</sup>|3x10<sup>-2</sup>|BMCL|8.2|Medium|0276
Benzidine|92-87-5|Information reviewed but value not estimated. Refer to IRIS Summary.||||||0135
Benzo[a]pyrene (BaP)||Not Assessed under the IRIS program.||||||
Benzo[b]fluoranthene||Not Assessed under the IRIS program.||||||
Benzo[g,h,i]perylene||Not Assessed under the IRIS program.||||||
Benzo[k]fluoranthene||Not Assessed under the IRIS program.||||||
Benzoic acid||Not Assessed under the IRIS program.||||||
Benzotrichloride||Not Assessed under the IRIS program.||||||
Benzyl chloride|100-44-7|Information reviewed but value not estimated. Refer to IRIS Summary.||||||0393
Beryllium and compounds|7440-41-7|Beryllium sensitization and progression to CBD|mg /m<sup>3</sup>|2x10<sup>-5</sup>|LOAEL (HEC)|0.0002|Medium|0012
Bidrin||Not Assessed under the IRIS program.||||||
Biphenthrin||Not Assessed under the IRIS program.||||||
1,1-Biphenyl|92-52-4|Information reviewed but value not estimated. Refer to IRIS Summary.||||||0013
Bis(2-chloro-1-methylethyl) ether||Not Assessed under the IRIS program.||||||
Bis(2-chloroethoxy)methane||Not Assessed under the IRIS program.||||||
Bis(chloroethyl)ether (BCEE)|111-44-4|Information reviewed but value not estimated. Refer to IRIS Summary.||||||0137
Bis(chloromethyl)ether (BCME)|542-88-1|Information reviewed but value not estimated. Refer to IRIS Summary.||||||0375
Bisphenol A.|80-05-7|Not Assessed under the IRIS program.||||||
Boron and Compounds||Information reviewed but value not estimated. Refer to IRIS Summary.||||||0410
Bromate|15541-45-4|Information reviewed but value not estimated. Refer to IRIS Summary.||||||1002
Brominated dibenzofurans|NA|Not Assessed under the IRIS program.||||||
Bromobenzene|108-86-1|Hepatocellular cytomegaly in female B6C3F1 mice|mg /m<sup>3</sup>|6x10<sup>-2</sup>|BMCL<sub>10</sub> (HEC)|63|Low/Medium|1020
Bromochloromethane||Not Assessed under the IRIS program.||||||
Bromodichloromethane||Not Assessed under the IRIS program.||||||
p-Bromodiphenyl ether||Not Assessed under the IRIS program.||||||
Bromoform|75-25-2|Information reviewed but value not estimated. Refer to IRIS Summary.||||||0214
Bromomethane|74-83-9|Degenerative and proliferative lesions of the olfactory epithelium of the nasal cavity|mg /m<sup>3</sup>|5x10<sup>-3</sup>|LOAEL (HEC)|0.48|High|0015
Bromotrichloromethane||Not Assessed under the IRIS program.||||||
Bromoxynil||Not Assessed under the IRIS program.||||||
Bromoxynil octanoate||Not Assessed under the IRIS program.||||||
1,3-Butadiene|106-99-0|Ovarian atrophy|mg /m<sup>3</sup>|2x10<sup>-3</sup>|BMCL<sub>10</sub> (HEC)|1.98|Medium|0139
n-Butanol||Not Assessed under the IRIS program.||||||
Butyl benzyl phthalate||Not Assessed under the IRIS program.||||||
Butylate||Not Assessed under the IRIS program.||||||
t-Butylchloride||Not Assessed under the IRIS program.||||||
Butylphthalyl butylglycolate (BPBG)||Not Assessed under the IRIS program.||||||
Cacodylic acid||Not Assessed under the IRIS program.||||||
Cadmium||Not Assessed under the IRIS program.||||||
Calcium cyanide||Not Assessed under the IRIS program.||||||
Caprolactam|105-60-2|Information reviewed but value not estimated. Refer to IRIS Summary.||||||0357
Captafol||Not Assessed under the IRIS program.||||||
Captan||Not Assessed under the IRIS program.||||||
Carbaryl|63-25-2|Information reviewed but value not estimated. Refer to IRIS Summary.||||||0019
Carbofuran||Not Assessed under the IRIS program.||||||
Carbon disulfide|75-15-0|Peripheral nervous system dysfunction|mg /m<sup>3</sup>|7x10<sup>-1</sup>|BMC<sub>10</sub> (HEC)|19.7|Medium|0217
Carbon tetrachloride|56-23-5|Not Assessed under the IRIS program.|Fatty changes in the liver|mg /m<sup>3</sup>|0.1|BMCL<sub>10</sub> (HEC)|14.3|0020
Carbonyl sulfide|463-58-1|Information reviewed but value not estimated. Refer to IRIS Summary.||||||0617
Carbosulfan||Not Assessed under the IRIS program.||||||
Carboxin||Not Assessed under the IRIS program.||||||
Cerium Oxide and Cerium Compounds|1306-38-3|Increased incidence of alveolar epithelial hyperplasia in the lungs of male and female rats|mg /m<sup>3</sup>|9x10<sup>-4</sup>|BMCL (HEC)|0.86|Low|1018
Chloral hydrate||Not Assessed under the IRIS program.||||||
Chloramben||Not Assessed under the IRIS program.||||||
Chlordane (Technical)|12789-03-6|Hepatic effects|mg /m<sup>3</sup>|7x10<sup>-4</sup>|NOAEL (HEC)|0.65|Low|0142
Chlordecone (Kepone)|143-50-0|Information reviewed but value not estimated. Refer to IRIS Summary.||||||1017
Chlorimuron-ethyl||Not Assessed under the IRIS program.||||||
Chlorine||Not Assessed under the IRIS program.||||||
Chlorine cyanide||Not Assessed under the IRIS program.||||||
Chlorine dioxide|10049-04-4|Vascular congestion and peribronchial edema (other effect: Hemorrhagic alveoli and congested capillaries in the lungs)|mg /m<sup>3</sup>|2x10<sup>-4</sup>|LOAEL (HEC)|0.64|Low|0496
Chlorite (sodium salt)|7758-19-2|Information reviewed but value not estimated. Refer to IRIS Summary.||||||0648
1-Chloro-1,1-difluoroethane|75-68-3|No adverse effects|mg /m<sup>3</sup>|5x10<sup>1</sup>|NOAEL (HEC)|14710|Medium|0661
2-Chloroacetophenone|532-27-4|Squamous hyperplasia of the nasal respiratory epithelium|mg /m<sup>3</sup>|3x10<sup>-5</sup>|LOAEL (HEC)|0.03|Low|0537
p-Chloroaniline||Not Assessed under the IRIS program.||||||
Chlorobenzene||Not Assessed under the IRIS program.||||||
Chlorobenzilate||Not Assessed under the IRIS program.||||||
1-Chlorobutane||Not Assessed under the IRIS program.||||||
2-Chlorobutane||Not Assessed under the IRIS program.||||||
Chlorocyclopentadiene||Not Assessed under the IRIS program.||||||
Chlorodifluoromethane|75-45-6|Increased kidney, adrenal and pituitary weights (other effect: Reduced maternal weight gain)|mg /m<sup>3</sup>|5x10<sup>1</sup>|NOAEL (HEC)|5260|Medium|0657
Chloroform||Not Assessed under the IRIS program.||||||
Chloromethyl methyl ether (CMME)||Not Assessed under the IRIS program.||||||
beta-Chloronaphthalene||Not Assessed under the IRIS program.||||||
2-Chlorophenol||Not Assessed under the IRIS program.||||||
p-Chlorophenyl methyl sulfide||Not Assessed under the IRIS program.||||||
p-Chlorophenyl methyl sulfone||Not Assessed under the IRIS program.||||||
p-Chlorophenyl methyl sulfoxide||Not Assessed under the IRIS program.||||||
Chloroprene|126-99-8|Increase in incidence of olfactory atrophy, alveolar hyperplasia, and splenic hematopoietic proliferation in male F344/N rats, female F344/N rats, and female B6C3F1 mice, respectively|mg /m<sup>3</sup>|2x10<sup>-2</sup>|BMDL (HEC)|2|Medium/High|1021
Chlorothalonil||Not Assessed under the IRIS program.||||||
o-Chlorotoluene||Not Assessed under the IRIS program.||||||
Chlorpropham||Not Assessed under the IRIS program.||||||
Chlorpyrifos||Not Assessed under the IRIS program.||||||
Chlorsulfuron||Not Assessed under the IRIS program.||||||
Chromium(III), insoluble salts|16065-83-1|Information reviewed but value not estimated. Refer to IRIS Summary.||||||0028
Chromium(VI) (Chromic acid mists and dissolved Cr(VI) aerosols)|18540-29-9|Nasal septum atrophy|mg /m<sup>3</sup>|8x10<sup>-6</sup>|LOAEL (ADJ)|0.000714|Low|0144
Chromium(VI) (Cr(VI) particulates)|18540-29-9|Lactate dehydrogenase in bronchioalveolar lavage fluid||1x10<sup>-4</sup>|BMC<sub>10</sub> (ADJ)|0.034|Medium|0144
Chrysene||Not Assessed under the IRIS program.||||||
Coke oven emissions||Not Assessed under the IRIS program.||||||
Copper||Not Assessed under the IRIS program.||||||
Copper cyanide||Not Assessed under the IRIS program.||||||
Creosote||Not Assessed under the IRIS program.||||||
Crotonaldehyde||Not Assessed under the IRIS program.||||||
Cumene|98-82-8|Increased kidney weights in female rats and adrenal weights in male and female rats|mg /m<sup>3</sup>|4x10<sup>-1</sup>|NOAEL (HEC)|435|Medium|0306
Cyanazine||Not Assessed under the IRIS program.||||||
Cyanide, free||Not Assessed under the IRIS program.||||||
Cyanogen||Not Assessed under the IRIS program.||||||
Cyanogen bromide||Not Assessed under the IRIS program.||||||
Cyclohexane|110-82-7|Reduced pup weights in the F1 and F2 generations|mg /m<sup>3</sup>|6|BMCL<sub>1sd</sub> (HEC)|1822|Low/Medium|1005
Cyclohexanone||Not Assessed under the IRIS program.||||||
Cyclohexylamine||Not Assessed under the IRIS program.||||||
Cyhalothrin/Karate||Not Assessed under the IRIS program.||||||
Cypermethrin||Not Assessed under the IRIS program.||||||
Cyromazine||Not Assessed under the IRIS program.||||||
Dacthal||Not Assessed under the IRIS program.||||||
Dalapon, sodium salt||Not Assessed under the IRIS program.||||||
Danitol||Not Assessed under the IRIS program.||||||
2,2',3,3',4,4',5,5',6,6'-Decabromodiphenyl ether (BDE-209)|1163-19-5|Information reviewed but value not estimated. Refer to IRIS Summary.||||||0035
Demeton||Not Assessed under the IRIS program.||||||
Di (2-ethylhexyl)phthalate (DEHP)||Not Assessed under the IRIS program.||||||
Di(2-ethylhexyl)adipate||Not Assessed under the IRIS program.||||||
2,4-Diaminotoluene|95-80-7|Information reviewed but value not estimated. Refer to IRIS Summary.||||||0536
Diazomethane|334-88-3|Information reviewed but value not estimated. Refer to IRIS Summary.||||||0616
Dibenz[a,h]anthracene||Not Assessed under the IRIS program.||||||
Dibenzofuran||Not Assessed under the IRIS program.||||||
1,2-Dibromo-3-chloropropane (DBCP)|96-12-8|Testicular effects|mg /m<sup>3</sup>|2x10<sup>-4</sup>|NOAEL (HEC)|0.17|Medium|0414
1,4-Dibromobenzene||Not Assessed under the IRIS program.||||||
Dibromochloromethane||Not Assessed under the IRIS program.||||||
Dibromodichloromethane||Not Assessed under the IRIS program.||||||
p,p'-Dibromodiphenyl ether||Not Assessed under the IRIS program.||||||
1,2-Dibromoethane|106-93-4|Nasal inflammation|mg /m<sup>3</sup>|9x10<sup>-3</sup>|BMCL<sub>10</sub> (HEC)|2.8|Medium|0361
Dibutyl phthalate|84-74-2|Information reviewed but value not estimated. Refer to IRIS Summary.||||||0038
Dicamba||Not Assessed under the IRIS program.||||||
Dichloroacetic acid|79-43-6|Information reviewed but value not estimated. Refer to IRIS Summary.||||||0654
1,3-Dichlorobenzene||Not Assessed under the IRIS program.||||||
1,4-Dichlorobenzene|106-46-7|Increased liver weights in P1 males|mg /m<sup>3</sup>|8x10<sup>-1</sup>|NOAEL (HEC)|75|Medium|0552
1,2-Dichlorobenzene||Not Assessed under the IRIS program.||||||
3,3'-Dichlorobenzidine|91-94-1|Information reviewed but value not estimated. Refer to IRIS Summary.||||||0504
Dichlorodifluoromethane||Not Assessed under the IRIS program.||||||
p,p'-Dichlorodiphenyl dichloroethane (DDD)||Not Assessed under the IRIS program.||||||
p,p'-Dichlorodiphenyldichloroethylene (DDE)||Not Assessed under the IRIS program.||||||
p,p'-Dichlorodiphenyltrichloroethane (DDT)||Not Assessed under the IRIS program.||||||
1,2-Dichloroethane||Not Assessed under the IRIS program.||||||
1,1-Dichloroethane||Not Assessed under the IRIS program.||||||
trans-1,2-Dichloroethylene|156-60-5|Information reviewed but value not estimated. Refer to IRIS Summary.||||||0314
cis-1,2-Dichloroethylene|156-59-2|Information reviewed but value not estimated. Refer to IRIS Summary.||||||0418
1,1-Dichloroethylene (1,1-DCE)|75-35-4|Liver toxicity (fatty change)|mg /m<sup>3</sup>|2x10<sup>-1</sup>|BMCL<sub>10</sub> (HEC)|6.9|Medium|0039
Dichloromethane|75-09-2|Hepatic effects (hepatic vacuolation)|mg /m<sup>3</sup>|6x10<sup>-1</sup>|BMDL<sub>10</sub> (HEC)|17.2|Medium/High|0070
2,4-Dichlorophenol||Not Assessed under the IRIS program.||||||
4-(2,4-Dichlorophenoxy)butyric acid (2,4-DB)||Not Assessed under the IRIS program.||||||
2,4-Dichlorophenoxyacetic acid (2,4-D)||Not Assessed under the IRIS program.||||||
1,2-Dichloropropane|78-87-5|Hyperplasia of the nasal mucosa|mg /m<sup>3</sup>|4x10<sup>-3</sup>|LOAEL (HEC)|1.3|Medium|0601
2,3-Dichloropropanol||Not Assessed under the IRIS program.||||||
1,3-Dichloropropene|542-75-6|Hypertrophy/ hyperplasia of the nasal respiratory epithelium|mg /m<sup>3</sup>|2x10<sup>-2</sup>|BMCL<sub>10</sub> (HEC)|0.72|High|0224
Dichlorvos|62-73-7|Decreased brain cholinesterase activity|mg /m<sup>3</sup>|5x10<sup>-4</sup>|NOAEL (HEC)|0.05|Medium|0151
Dicofol||Not Assessed under the IRIS program.||||||
Dieldrin||Not Assessed under the IRIS program.||||||
Diesel engine exhaust|NA|Pulmonary inflammation and histopathology|mg /m<sup>3</sup>|5x10<sup>-3</sup>|NOAEL (HEC)|0.144|Medium|0642
Diethyl phthalate||Not Assessed under the IRIS program.||||||
Diethyl sulfate|64-67-5|Information reviewed but value not estimated. Refer to IRIS Summary.||||||0615
Diethyl-p-nitrophenylphosphate||Not Assessed under the IRIS program.||||||
Diethylene glycol dinitrate (DEGDN)||Not Assessed under the IRIS program.||||||
Difenzoquat||Not Assessed under the IRIS program.||||||
Diflubenzuron||Not Assessed under the IRIS program.||||||
1,1-Difluoroethane|75-37-6|No adverse effects observed|mg /m<sup>3</sup>|4x10<sup>1</sup>|NOAEL (HEC)|12051|Medium|0665
Diisopropyl methylphosphonate (DIMP)||Not Assessed under the IRIS program.||||||
Dimethipin||Not Assessed under the IRIS program.||||||
Dimethoate||Not Assessed under the IRIS program.||||||
Dimethyl phthalate|131-11-3|Information reviewed but value not estimated. Refer to IRIS Summary.||||||0353
Dimethyl sulfate|77-78-1|Information reviewed but value not estimated. Refer to IRIS Summary.||||||0365
Dimethyl terephthalate (DMT)||Not Assessed under the IRIS program.||||||
Dimethylamine|124-40-3|Information reviewed but value not estimated. Refer to IRIS Summary.||||||0228
N-N-Dimethylaniline||Not Assessed under the IRIS program.||||||
3,3-Dimethylbenzidine|119-93-7|Information reviewed but value not estimated. Refer to IRIS Summary.||||||0538
N,N-Dimethylformamide|68-12-2|Digestive disturbances and minimal hepatic changes suggestive of liver abnormalities|mg /m<sup>3</sup>|3x10<sup>-2</sup>|LOAEL (HEC)|7.9|Medium|0511
3,4-Dimethylphenol||Not Assessed under the IRIS program.||||||
2,6-Dimethylphenol||Not Assessed under the IRIS program.||||||
2,4-Dimethylphenol||Not Assessed under the IRIS program.||||||
4,6-Dinitro-o-cyclohexyl phenol||Not Assessed under the IRIS program.||||||
m-Dinitrobenzene||Not Assessed under the IRIS program.||||||
o-Dinitrobenzene||Not Assessed under the IRIS program.||||||
2,4-Dinitrophenol|51-28-5|Information reviewed but value not estimated. Refer to IRIS Summary.||||||0152
2,4-Dinitrotoluene|121-14-2|Information reviewed but value not estimated. Refer to IRIS Summary.||||||0542
2,4-/2,6-Dinitrotoluene mixture||Not Assessed under the IRIS program.||||||
Dinoseb||Not Assessed under the IRIS program.||||||
1,4-Dioxane|123-91-1|Information reviewed but value not estimated. Refer to IRIS Summary.||||||0326
Diphenamid||Not Assessed under the IRIS program.||||||
Diphenylamine||Not Assessed under the IRIS program.||||||
1,2-Diphenylhydrazine|122-66-7|Information reviewed but value not estimated. Refer to IRIS Summary.||||||0049
Diquat||Not Assessed under the IRIS program.||||||
Disulfoton||Not Assessed under the IRIS program.||||||
1,4-Dithiane||Not Assessed under the IRIS program.||||||
Diuron||Not Assessed under the IRIS program.||||||
Dodine||Not Assessed under the IRIS program.||||||
Endosulfan||Not Assessed under the IRIS program.||||||
Endothall||Not Assessed under the IRIS program.||||||
Endrin||Not Assessed under the IRIS program.||||||
Epichlorohydrin|106-89-8|Changes in the nasal turbinates|mg /m<sup>3</sup>|1x10<sup>-3</sup>|NOAEL (HEC)|0.36|Medium|0050
1,2-Epoxybutane (EBU)|106-88-7|Degenerative lesions of the nasal cavity|mg /m<sup>3</sup>|2x10<sup>-2</sup>|LOAEL (HEC)|4.8|Medium|0630
Ethephon||Not Assessed under the IRIS program.||||||
Ethion||Not Assessed under the IRIS program.||||||
2-Ethoxyethanol|110-80-5|Decreased testis weight, seminiferous tubule degeneration and decreased hemoglobin|mg /m<sup>3</sup>|2x10<sup>-1</sup>|NOAEL (HEC)|68|Medium|0513
Ethyl acetate||Not Assessed under the IRIS program.||||||
Ethyl carbamate|51-79-6|Information reviewed but value not estimated. Refer to IRIS Summary.||||||0629
Ethyl chloride|75-00-3|Delayed fetal ossification|mg /m<sup>3</sup>|1x10<sup>1<7sup>|NOAEL (HEC)|4000|Medium|0523
S-Ethyl dipropylthiocarbamate (EPTC)||Not Assessed under the IRIS program.||||||
Ethyl ether||Not Assessed under the IRIS program.||||||
Ethyl p-nitrophenyl phenylphosphorothioate (EPN)||Not Assessed under the IRIS program.||||||
Ethylbenzene|100-41-4|Developmental toxicity|mg /m<sup>3</sup>|1|NOAEL (HEC)|434|Low|0051
Ethylene diamine|107-15-3|Information reviewed but value not estimated. Refer to IRIS Summary.||||||0528
Ethylene glycol||Not Assessed under the IRIS program.||||||
Ethylene glycol monobutyl ether (EGBE) (2-Butoxyethanol)|111-76-2|Hemosiderin deposition in the liver|mg /m<sup>3</sup>|1.6|BMCL (HEC)|16|Medium/High|0500
Ethylene thiourea (ETU)||Not Assessed under the IRIS program.||||||
Ethyleneimine|151-56-4|Information reviewed but value not estimated. Refer to IRIS Summary.||||||0631
Ethylphthalyl ethylglycolate (EPEG)||Not Assessed under the IRIS program.||||||
Express||Not Assessed under the IRIS program.||||||
Fenamiphos||Not Assessed under the IRIS program.||||||
Fluometuron||Not Assessed under the IRIS program.||||||
Fluoranthene||Not Assessed under the IRIS program.||||||
Fluorene||Not Assessed under the IRIS program.||||||
Fluorine (soluble fluoride)||Not Assessed under the IRIS program.||||||
Fluridone||Not Assessed under the IRIS program.||||||
Flurprimidol||Not Assessed under the IRIS program.||||||
Flutolanil||Not Assessed under the IRIS program.||||||
Fluvalinate||Not Assessed under the IRIS program.||||||
Folpet||Not Assessed under the IRIS program.||||||
Fomesafen||Not Assessed under the IRIS program.||||||
Fonofos||Not Assessed under the IRIS program.||||||
Formaldehyde||Not Assessed under the IRIS program.||||||
Formic acid||Not Assessed under the IRIS program.||||||
Fosetyl-al||Not Assessed under the IRIS program.||||||
Furan||Not Assessed under the IRIS program.||||||
Furfural||Not Assessed under the IRIS program.||||||
Furmecyclox||Not Assessed under the IRIS program.||||||
Glufosinate-ammonium||Not Assessed under the IRIS program.||||||
Glycidaldehyde||Not Assessed under the IRIS program.||||||
Glyphosate||Not Assessed under the IRIS program.||||||
Haloxyfop-methyl||Not Assessed under the IRIS program.||||||
Harmony||Not Assessed under the IRIS program.||||||
Heptachlor||Not Assessed under the IRIS program.||||||
Heptachlor epoxide||Not Assessed under the IRIS program.||||||
n-Heptane||Not Assessed under the IRIS program.||||||
Hexabromobenzene||Not Assessed under the IRIS program.||||||
Hexabromodiphenyl ether||Not Assessed under the IRIS program.||||||
2,2',4,4',5,5'-Hexabromodiphenyl ether (BDE-153)|68631-49-2|Information reviewed but value not estimated. Refer to IRIS Summary.||||||1009
Hexachlorobenzene|118-74-1|Information reviewed but value not estimated. Refer to IRIS Summary.||||||0374
Hexachlorobutadiene||Not Assessed under the IRIS program.||||||
alpha-Hexachlorocyclohexane (alpha-HCH)||Not Assessed under the IRIS program.||||||
beta-Hexachlorocyclohexane (beta-HCH)||Not Assessed under the IRIS program.||||||
delta-Hexachlorocyclohexane (delta-HCH)||Not Assessed under the IRIS program.||||||
epsilon-Hexachlorocyclohexane (epsilon-HC)||Not Assessed under the IRIS program.||||||
gamma-Hexachlorocyclohexane (gamma-HCH)||Not Assessed under the IRIS program.||||||
technical Hexachlorocyclohexane (t-HCH)||Not Assessed under the IRIS program.||||||
Hexachlorocyclopentadiene (HCCPD)|77-47-4|Suppurative inflammation of the nose|mg /m<sup>3</sup>|2x10<sup>-4</sup>|NOAEL (HEC)|0.024|Medium|0059
Hexachlorodibenzo-p-dioxin (HxCDD), mixture of 1,2,3,6,7,8-HxCDD and 1,2,3,7,8,9-HxCDD||Not Assessed under the IRIS program.||||||
Hexachloroethane|67-72-1|Neurotoxicity (tremors and ruffled pelt)|mg /m<sup>3</sup>|3x10<sup>-2</sup>|NOAEL (HEC)|83|Low|0167
Hexachlorophene||Not Assessed under the IRIS program.||||||
Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX)||Not Assessed under the IRIS program.||||||
1,6-Hexamethylene diisocyanate||Not Assessed under the IRIS program.||||||
n-Hexane||Not Assessed under the IRIS program.||||||
2-Hexanone||Not Assessed under the IRIS program.||||||
Hexazinone||Not Assessed under the IRIS program.||||||
Hydrazine/Hydrazine sulfate||Not Assessed under the IRIS program.||||||
Hydrogen Cyanide and Cyanide Salts||Not Assessed under the IRIS program.||||||
Hydrogen chloride||Not Assessed under the IRIS program.||||||
Hydrogen sulfide||Not Assessed under the IRIS program.||||||
Hydroquinone||Not Assessed under the IRIS program.||||||
Imazalil||Not Assessed under the IRIS program.||||||
Imazaquin||Not Assessed under the IRIS program.||||||
Indeno[1,2,3-cd]pyrene||Not Assessed under the IRIS program.||||||
Iprodione||Not Assessed under the IRIS program.||||||
Isobutyl alcohol||Not Assessed under the IRIS program.||||||
Isophorone||Not Assessed under the IRIS program.||||||
Isopropalin||Not Assessed under the IRIS program.||||||
Isopropyl methyl phosphonic acid (IMPA)||Not Assessed under the IRIS program.||||||
Isoxaben||Not Assessed under the IRIS program.||||||
Lactofen||Not Assessed under the IRIS program.||||||
Lead and compounds (inorganic)||Not Assessed under the IRIS program.||||||
d-Limonene||Not Assessed under the IRIS program.||||||
Linuron||Not Assessed under the IRIS program.||||||
Londax||Not Assessed under the IRIS program.||||||
Malathion||Not Assessed under the IRIS program.||||||
Maleic anhydride||Not Assessed under the IRIS program.||||||
Maleic hydrazide||Not Assessed under the IRIS program.||||||
Maneb||Not Assessed under the IRIS program.||||||
Manganese||Not Assessed under the IRIS program.||||||
Mepiquat chloride||Not Assessed under the IRIS program.||||||
Mercuric chloride (HgCl2)||Not Assessed under the IRIS program.||||||
Mercury, elemental||Not Assessed under the IRIS program.||||||
Merphos||Not Assessed under the IRIS program.||||||
Merphos oxide||Not Assessed under the IRIS program.||||||
Metalaxyl||Not Assessed under the IRIS program.||||||
Methacrylonitrile||Not Assessed under the IRIS program.||||||
Methamidophos||Not Assessed under the IRIS program.||||||
Methanol||Not Assessed under the IRIS program.||||||
Methidathion||Not Assessed under the IRIS program.||||||
Methomyl||Not Assessed under the IRIS program.||||||
Methoxychlor||Not Assessed under the IRIS program.||||||
2-Methoxyethanol||Not Assessed under the IRIS program.||||||
Methyl acrylate||Not Assessed under the IRIS program.||||||
Methyl chloride||Not Assessed under the IRIS program.||||||
Methyl chlorocarbonate||Not Assessed under the IRIS program.||||||
Methyl ethyl ketone (MEK)||Not Assessed under the IRIS program.||||||
Methyl iodide||Not Assessed under the IRIS program.||||||
Methyl isobutyl ketone (MIBK)||Not Assessed under the IRIS program.||||||
Methyl isocyanate||Not Assessed under the IRIS program.||||||
Methyl methacrylate||Not Assessed under the IRIS program.||||||
Methyl parathion||Not Assessed under the IRIS program.||||||
Methyl tert-butyl ether (MTBE)||Not Assessed under the IRIS program.||||||
4-(2-Methyl-4-chlorophenoxy) butyric acid (MCPB)||Not Assessed under the IRIS program.||||||
2-(2-Methyl-4-chlorophenoxy)propionic acid (MCPP)||Not Assessed under the IRIS program.||||||
2-Methyl-4-chlorophenoxyacetic acid (MCPA)||Not Assessed under the IRIS program.||||||
Methylene Diphenyl Diisocyanate (monomeric MDI) and polymeric MDI (PMDI)||Not Assessed under the IRIS program.||||||
4,4'-Methylene bis(N,N'-dimethyl)aniline||Not Assessed under the IRIS program.||||||
Methylmercury (MeHg)||Not Assessed under the IRIS program.||||||
2-Methylnaphthalene||Not Assessed under the IRIS program.||||||
4-Methylphenol||Not Assessed under the IRIS program.||||||
3-Methylphenol||Not Assessed under the IRIS program.||||||
2-Methylphenol||Not Assessed under the IRIS program.||||||
Metolachlor||Not Assessed under the IRIS program.||||||
Metribuzin||Not Assessed under the IRIS program.||||||
Mirex||Not Assessed under the IRIS program.||||||
Molinate||Not Assessed under the IRIS program.||||||
Molybdenum||Not Assessed under the IRIS program.||||||
Monochloramine||Not Assessed under the IRIS program.||||||
Naled||Not Assessed under the IRIS program.||||||
Naphthalene||Not Assessed under the IRIS program.||||||
Napropamide||Not Assessed under the IRIS program.||||||
Nickel carbonyl||Not Assessed under the IRIS program.||||||
Nickel refinery dust||Not Assessed under the IRIS program.||||||
Nickel subsulfide||Not Assessed under the IRIS program.||||||
Nickel, soluble salts||Not Assessed under the IRIS program.||||||
Nitrapyrin||Not Assessed under the IRIS program.||||||
Nitrate||Not Assessed under the IRIS program.||||||
Nitric oxide||Not Assessed under the IRIS program.||||||
Nitrite||Not Assessed under the IRIS program.||||||
Nitrobenzene||Not Assessed under the IRIS program.||||||
Nitrogen dioxide||Not Assessed under the IRIS program.||||||
Nitroguanidine||Not Assessed under the IRIS program.||||||
p-Nitrophenol||Not Assessed under the IRIS program.||||||
2-Nitropropane||Not Assessed under the IRIS program.||||||
N-Nitroso-N-methylethylamine||Not Assessed under the IRIS program.||||||
N-Nitroso-di-n-butylamine||Not Assessed under the IRIS program.||||||
N-Nitrosodi-N-propylamine||Not Assessed under the IRIS program.||||||
N-Nitrosodiethanolamine||Not Assessed under the IRIS program.||||||
N-Nitrosodiethylamine||Not Assessed under the IRIS program.||||||
N-Nitrosodimethylamine||Not Assessed under the IRIS program.||||||
N-Nitrosodiphenylamine||Not Assessed under the IRIS program.||||||
N-Nitrosopyrrolidine||Not Assessed under the IRIS program.||||||
Nonabromodiphenyl ether||Not Assessed under the IRIS program.||||||
Norflurazon||Not Assessed under the IRIS program.||||||
NuStar||Not Assessed under the IRIS program.||||||
Octabromodiphenyl ether||Not Assessed under the IRIS program.||||||
Octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine (HMX)||Not Assessed under the IRIS program.||||||
Oryzalin||Not Assessed under the IRIS program.||||||
Oxadiazon||Not Assessed under the IRIS program.||||||
Oxamyl||Not Assessed under the IRIS program.||||||
Oxyfluorfen||Not Assessed under the IRIS program.||||||
Paclobutrazol||Not Assessed under the IRIS program.||||||
Paraquat||Not Assessed under the IRIS program.||||||
Parathion||Not Assessed under the IRIS program.||||||
Pendimethalin||Not Assessed under the IRIS program.||||||
Pentabromodiphenyl ether||Not Assessed under the IRIS program.||||||
2,2',4,4',5-Pentabromodiphenyl ether (BDE-99)||Not Assessed under the IRIS program.||||||
Pentachlorobenzene||Not Assessed under the IRIS program.||||||
Pentachlorocyclopentadiene||Not Assessed under the IRIS program.||||||
Pentachloronitrobenzene (PCNB)||Not Assessed under the IRIS program.||||||
Pentachlorophenol||Not Assessed under the IRIS program.||||||
Pentafluoroethane||Not Assessed under the IRIS program.||||||
Perchlorate (ClO4) and Perchlorate Salts||Not Assessed under the IRIS program.||||||
Permethrin||Not Assessed under the IRIS program.||||||
Phenanthrene||Not Assessed under the IRIS program.||||||
Phenmedipham||Not Assessed under the IRIS program.||||||
Phenol||Not Assessed under the IRIS program.||||||
m-Phenylenediamine||Not Assessed under the IRIS program.||||||
Phenylmercuric acetate||Not Assessed under the IRIS program.||||||
Phosalone||Not Assessed under the IRIS program.||||||
Phosgene||Not Assessed under the IRIS program.||||||
Phosmet||Not Assessed under the IRIS program.||||||
Phosphine||Not Assessed under the IRIS program.||||||
Phosphoric acid||Not Assessed under the IRIS program.||||||
Phthalic anhydride||Not Assessed under the IRIS program.||||||
Picloram||Not Assessed under the IRIS program.||||||
Pirimiphos-methyl||Not Assessed under the IRIS program.||||||
Polychlorinated biphenyls (PCBs)||Not Assessed under the IRIS program.||||||
Potassium cyanide||Not Assessed under the IRIS program.||||||
Potassium silver cyanide||Not Assessed under the IRIS program.||||||
Prochloraz||Not Assessed under the IRIS program.||||||
Prometon||Not Assessed under the IRIS program.||||||
Prometryn||Not Assessed under the IRIS program.||||||
Pronamide||Not Assessed under the IRIS program.||||||
Propachlor||Not Assessed under the IRIS program.||||||
Propanil||Not Assessed under the IRIS program.||||||
Propargite||Not Assessed under the IRIS program.||||||
Propargyl alcohol||Not Assessed under the IRIS program.||||||
Propazine||Not Assessed under the IRIS program.||||||
Propham||Not Assessed under the IRIS program.||||||
Propiconazole||Not Assessed under the IRIS program.||||||
beta-Propiolactone||Not Assessed under the IRIS program.||||||
Propionaldehyde||Not Assessed under the IRIS program.||||||
Propylene glycol||Not Assessed under the IRIS program.||||||
Propylene glycol monoethyl ether||Not Assessed under the IRIS program.||||||
Propylene glycol monomethyl ether (PGME)||Not Assessed under the IRIS program.||||||
Propylene oxide||Not Assessed under the IRIS program.||||||
Propyleneimine||Not Assessed under the IRIS program.||||||
Pursuit||Not Assessed under the IRIS program.||||||
Pydrin||Not Assessed under the IRIS program.||||||
Pyrene||Not Assessed under the IRIS program.||||||
Pyridine||Not Assessed under the IRIS program.||||||
Quinalphos||Not Assessed under the IRIS program.||||||
Quinoline||Not Assessed under the IRIS program.||||||
Quinone||Not Assessed under the IRIS program.||||||
Radium 226,228||Not Assessed under the IRIS program.||||||
Radon 222||Not Assessed under the IRIS program.||||||
Refractory ceramic fibers||Not Assessed under the IRIS program.||||||
Resmethrin||Not Assessed under the IRIS program.||||||
Rotenone||Not Assessed under the IRIS program.||||||
Savey||Not Assessed under the IRIS program.||||||
Selenious acid||Not Assessed under the IRIS program.||||||
Selenium and Compounds||Not Assessed under the IRIS program.||||||
Selenium sulfide||Not Assessed under the IRIS program.||||||
Selenourea||Not Assessed under the IRIS program.||||||
Sethoxydim||Not Assessed under the IRIS program.||||||
Silver||Not Assessed under the IRIS program.||||||
Silver cyanide||Not Assessed under the IRIS program.||||||
Simazine||Not Assessed under the IRIS program.||||||
Sodium azide||Not Assessed under the IRIS program.||||||
Sodium cyanide||Not Assessed under the IRIS program.||||||
Sodium diethyldithiocarbamate||Not Assessed under the IRIS program.||||||
Sodium fluoroacetate||Not Assessed under the IRIS program.||||||
Strontium||Not Assessed under the IRIS program.||||||
Strychnine||Not Assessed under the IRIS program.||||||
Styrene||Not Assessed under the IRIS program.||||||
Systhane||Not Assessed under the IRIS program.||||||
Tebuthiuron||Not Assessed under the IRIS program.||||||
Terbacil||Not Assessed under the IRIS program.||||||
Terbutryn||Not Assessed under the IRIS program.||||||
Tetrabromodiphenyl ether||Not Assessed under the IRIS program.||||||
2,2',4,4'-Tetrabromodiphenyl ether (BDE-47)||Not Assessed under the IRIS program.||||||
1,2,4,5-Tetrachlorobenzene||Not Assessed under the IRIS program.||||||
Tetrachlorocyclopentadiene||Not Assessed under the IRIS program.||||||
2,3,7,8-Tetrachlorodibenzo-p-dioxin||Not Assessed under the IRIS program.||||||
1,1,1,2-Tetrachloroethane||Not Assessed under the IRIS program.||||||
1,1,2,2-Tetrachloroethane||Not Assessed under the IRIS program.||||||
Tetrachloroethylene||Not Assessed under the IRIS program.||||||
2,3,4,6-Tetrachlorophenol||Not Assessed under the IRIS program.||||||
Tetrachlorovinphos||Not Assessed under the IRIS program.||||||
Tetraethyl lead||Not Assessed under the IRIS program.||||||
Tetraethyldithiopyrophosphate||Not Assessed under the IRIS program.||||||
1,1,1,2-Tetrafluoroethane||Not Assessed under the IRIS program.||||||
Tetrahydrofuran||Not Assessed under the IRIS program.||||||
Thallium (I), soluble salts||Not Assessed under the IRIS program.||||||
Thallium acetate||Not Assessed under the IRIS program.||||||
Thallium carbonate||Not Assessed under the IRIS program.||||||
Thallium chloride||Not Assessed under the IRIS program.||||||
Thallium nitrate||Not Assessed under the IRIS program.||||||
Thallium oxide||Not Assessed under the IRIS program.||||||
Thallium selenite||Not Assessed under the IRIS program.||||||
Thallium(I) sulfate||Not Assessed under the IRIS program.||||||
Thiobencarb||Not Assessed under the IRIS program.||||||
Thiophanate-methyl||Not Assessed under the IRIS program.||||||
Thiram||Not Assessed under the IRIS program.||||||
Toluene||Not Assessed under the IRIS program.||||||
2,4-/2,6-Toluene diisocyanate mixture (TDI)||Not Assessed under the IRIS program.||||||
Toxaphene||Not Assessed under the IRIS program.||||||
Tralomethrin||Not Assessed under the IRIS program.||||||
Triallate||Not Assessed under the IRIS program.||||||
Triasulfuron||Not Assessed under the IRIS program.||||||
1,2,4-Tribromobenzene||Not Assessed under the IRIS program.||||||
Tribromochloromethane||Not Assessed under the IRIS program.||||||
Tribromodiphenyl ether||Not Assessed under the IRIS program.||||||
Tributyltin oxide (TBTO)||Not Assessed under the IRIS program.||||||
1,1,2-Trichloro-1,2,2-trifluoroethane (CFC-113)||Not Assessed under the IRIS program.||||||
Trichloroacetic acid||Not Assessed under the IRIS program.||||||
1,2,4-Trichlorobenzene||Not Assessed under the IRIS program.||||||
Trichlorocyclopentadiene||Not Assessed under the IRIS program.||||||
1,1,2-Trichloroethane||Not Assessed under the IRIS program.||||||
1,1,1-Trichloroethane||Not Assessed under the IRIS program.||||||
Trichloroethylene||Not Assessed under the IRIS program.||||||
Trichlorofluoromethane||Not Assessed under the IRIS program.||||||
2,4,5-Trichlorophenol||Not Assessed under the IRIS program.||||||
2,4,6-Trichlorophenol||Not Assessed under the IRIS program.||||||
2(2,4,5-Trichlorophenoxy) propionic acid (2,4,5-TP)||Not Assessed under the IRIS program.||||||
2,4,5-Trichlorophenoxyacetic acid (2,4,5-T)||Not Assessed under the IRIS program.||||||
1,1,2-Trichloropropane||Not Assessed under the IRIS program.||||||
1,2,3-Trichloropropane||Not Assessed under the IRIS program.||||||
Tricresol||Not Assessed under the IRIS program.||||||
Tridiphane||Not Assessed under the IRIS program.||||||
Triethylamine||Not Assessed under the IRIS program.||||||
Triethylene glycol monobutyl ether||Not Assessed under the IRIS program.||||||
Triethylene glycol monoethyl ether||Not Assessed under the IRIS program.||||||
Trifluralin||Not Assessed under the IRIS program.||||||
2,2,4-Trimethylpentane||Not Assessed under the IRIS program.||||||
1,3,5-Trinitrobenzene||Not Assessed under the IRIS program.||||||
2,4,6-Trinitrotoluene (TNT)||Not Assessed under the IRIS program.||||||
Uranium, natural||Not Assessed under the IRIS program.||||||
Uranium, soluble salts||Not Assessed under the IRIS program.||||||
Urea||Not Assessed under the IRIS program.||||||
Vanadium pentoxide||Not Assessed under the IRIS program.||||||
Vernam||Not Assessed under the IRIS program.||||||
Vinclozolin||Not Assessed under the IRIS program.||||||
Vinyl acetate||Not Assessed under the IRIS program.||||||
Vinyl bromide||Not Assessed under the IRIS program.||||||
Vinyl chloride||Not Assessed under the IRIS program.||||||
Warfarin||Not Assessed under the IRIS program.||||||
White phosphorus||Not Assessed under the IRIS program.||||||
Xylenes||Not Assessed under the IRIS program.||||||
Zinc and Compounds||Not Assessed under the IRIS program.||||||
Zinc cyanide||Not Assessed under the IRIS program.||||||
Zinc phosphide||Not Assessed under the IRIS program.||||||
Zineb||Not Assessed under the IRIS program.||||||
</t2b>


==References==
==References==

Latest revision as of 13:02, 11 March 2014

This page provides a description and a link to a "IRIS" database that provides information needed when modeling exposure levels or performing exposure assessment.

Short description

IRIS is a database of human health effects that may result from exposure to various substances found in the environment. The heart of the IRIS system is its collection of computer files covering individual chemicals. These chemical files contain descriptive and quantitative information in the following categories: a) Oral reference doses and inhalation reference concentrations (RfDs and RfCs, respectively) for chronic noncarcinogenic health effects, b) Hazard identification, oral slope factors, and oral and inhalation unit risks for carcinogenic effects. Database includes over 500 chemicals.

Long description

http://www.nlm.nih.gov/pubs/factsheets/irisfs.html

Link

http://www.epa.gov/iris/

Key words

human health effects, exposure, toxicology, carcinogenity, hazards

Data scrapping

IRIS database is accessible from this link: http://cfpub.epa.gov/ncea/iris/compare.cfm. The critical data can be obtained at once if all substances and all types of data are selected. A result is an html file with several tables from which the data can be scrapped and transformed into a better format. The January 4th, 2012, version was downloaded from IRIS and saved on this page (see the file below). Who could do this?

Reference system in IRIS database. The number (e.g. 0442) refers to the IRIS chemical identifier. 

QuickView
http://cfpub.epa.gov/ncea/iris/quickview.cfm?substance_nmbr=0442#reforal  Oral RfDs
http://cfpub.epa.gov/ncea/iris/quickview.cfm?substance_nmbr=0442#refinhal Inhalation RfCs
http://cfpub.epa.gov/ncea/iris/quickview.cfm?substance_nmbr=0442#woe      Weight-of-Evidence Characterizations
http://cfpub.epa.gov/ncea/iris/quickview.cfm?substance_nmbr=0442#quaoral  Oral Slope Factors/Drinking Water Unit Risks
http://cfpub.epa.gov/ncea/iris/quickview.cfm?substance_nmbr=0442#quainhal Inhalation Unit Risks

IRIS Summary 
http://www.epa.gov/iris/subst/0442.htm#reforal
http://www.epa.gov/iris/subst/0442.htm#refinhal
http://www.epa.gov/iris/subst/0442.htm#woe
http://www.epa.gov/iris/subst/0442.htm#quaoral
http://www.epa.gov/iris/subst/0442.htm#quainhal

Toxicological Review (PDF)
http://www.epa.gov/iris/toxreviews/0128tr.pdf (this does not exist for many compounds)

←--#: . Tämähän alkaa olla oikein hyvä! Alla vielä muutamia kommentteja. --Jouni 20:34, 28 June 2012 (EEST) (type: truth; paradigms: science: defence)

  • Tulokset on tässä kirjoitettu muotoon 3.4x10-3. Joko interpret-funktiota on päivitettävä siten, että se ymmärtää tämän, tai sitten kaikki näiden taulukoiden tulokset pitää muuttaa muotoon 3.4e-3 (jonka R ymmärtää oikein, kun käytetään as.numericia). Tuntuu, että interpretin päivitys olisi parempi vaihtoehto.
  • Yksiköt pitäisi muuttaa tietokoneelle ymmärrettäväksi. Vaihtoehtoja: a) Unit conversions -sivulle lisätään kaikki tässä esiintyvät uudet yksiköt, niin että niille saadaan muunnosohjeet (esim. mg /kg-day → mg /kg /d tai per µg /m3 → m3 /µg. b) Kaikki yksiköt tällä sivulla muutetaan tuohon standardimuotoon. Mikä tuntuisi järkevältä?


⇤--#: . Jos jossakin taulukossa joka rivillä on sama yksikkö, koko saraketta ei tarvita vaan riittää yksikön ilmoittaminen osoiterivillä. --Jouni 20:34, 28 June 2012 (EEST) (type: truth; paradigms: science: attack)

⇤--#: . Ei tätä kannata tehdä rivi kerrallaan, vaan ottaa koko viiden taulukon tiedosto (ks. Related files) muokata siitä tekstinkäsittelyohjelmalla viisi t2b-taulukkoa. Etsi-korvaa-toiminnolla voi tehdä suurimman osan muotoiluista. Kannattaa kysyä apua jos ei osaa, koska muuten työssä menee päiviä. --Jouni 10:42, 20 June 2012 (EEST) (type: truth; paradigms: science: attack)

⇤--#: . Huomaa, että IRIS identifier on tärkeä. Se löytyy nettilinkeistä (esim. Acenaphthenen QuickView on tämmöinen linkki: http://cfpub.epa.gov/ncea/iris/quickview.cfm?substance_nmbr=0442#reforal ja siitä näkee, että tämän aineen IRIS identifier on 0442. --Jouni 10:42, 20 June 2012 (EEST) (type: truth; paradigms: science: attack)

See also

References


Related files

<mfanonymousfilelist></mfanonymousfilelist>

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