ERF for Frambozadrine in rats: Difference between revisions

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'''Scope'''<br>
{{Variable|Exposure-response functions}}
'''[[Frambozadrine]] dose-response function in rats''' describes the long-term health impact(s) caused by [[frambozadrine]] as a function of dose in rats. This dose-response function applies only to continuous long-term exposures of [[frambozadrine]] (like in chronic studies).
[[Category:Frambozadrine]]
[[Category:Health effects]]
[[Category:Health effects]]


== Definition ==  
==Question==
 
'''[[Frambozadrine]] dose-response function in rats''' describes the long-term health impact(s) caused by [[frambozadrine]] as a function of dose in rats. This [[Variable:Generalized dose-response function|dose-response function]] applies only to continuous long-term exposures of [[frambozadrine]] (like in chronic studies).
 
==Answer==
 
It is not clear which of the plausible methods for estimating the result is the best. The discussion is ongoing. {{disclink|Which method is the best for dose-response estimation?}}
 
<t2b index="Disease,Response metric,Exposure route,Exposure metric,Exposure unit,Threshold,ERF parameter,Observation" locations="ERF,Description" unit="?">
</t2b>
 
===Non-parametric Bayesian estimation===
 
Males and Females combined
 
{| {{prettytable}}
!Dose levels
!MLE
!Prior
!Posterior mean
!Variance
|----
|0
|0.053
|0.125
|0.0571
|0.0634
|----
|1.2
|0.133
|0.25
|0.1052
|0.0348
|----
|1.8
|0.102
|0.375
|0.13
|0.0241
|----
|15
|0.091
|0.5
|0.154
|0.021
|----
|21
|0.064
|0.625
|0.1799
|0.0551
|----
|82
|0.511
|0.75
|0.4969
|0.2762
|----
|109
|0.687
|0.875
|0.687
|0.2778
|----
|}
 
==Rationale==  


=== Causality ===  
=== Causality ===  
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====Plausible dose-response functions====
====Plausible dose-response functions====


*[[Variable:Generalized dose-response function|Generalized dose-response function]]
*[[Multistage model]] (first order)
*[[Multistage model]] (first order)
*[[Multistage model]] (second order)
*[[Multistage model]] (second order)
*[[Weibull model]]
*[[Weibull model]]
=== Unit ===
probability of impact


=== Formula ===  
=== Formula ===  
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</rcode>  
</rcode>  


=== Unit ===  
==See also==


probability of impact
==References==


== Result ==
<references/>

Latest revision as of 08:07, 13 October 2012

Question

Frambozadrine dose-response function in rats describes the long-term health impact(s) caused by frambozadrine as a function of dose in rats. This dose-response function applies only to continuous long-term exposures of frambozadrine (like in chronic studies).

Answer

It is not clear which of the plausible methods for estimating the result is the best. The discussion is ongoing. D↷

You have error(s) in your data:

Number of indices and result cells does not match

Non-parametric Bayesian estimation

Males and Females combined

Dose levels MLE Prior Posterior mean Variance
0 0.053 0.125 0.0571 0.0634
1.2 0.133 0.25 0.1052 0.0348
1.8 0.102 0.375 0.13 0.0241
15 0.091 0.5 0.154 0.021
21 0.064 0.625 0.1799 0.0551
82 0.511 0.75 0.4969 0.2762
109 0.687 0.875 0.687 0.2778

Rationale

Causality

Upstream variables not defined.

Data

Toxicological data about frambozadrine in rats.

Dose(mg/kg-day) Total no rats Hyperkeratosis
Male
0 47 2
1.2 45 6
15 44 4
82 47 24
Female
0 48 3
1.8 49 5
21 47 3
109 48 33

Plausible dose-response functions

Unit

probability of impact

Formula

Methods for estimating dose-responses

+ Show code

See also

References

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