Intake of PCDD/F from fish in Beneris: Difference between revisions
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[[Category:Beneris]] | |||
[[Category:Fish]] | |||
[[Category:Exposures]] | |||
[[Category:Dioxins]] | |||
== | == '''Scope''' == | ||
<br> '''Intake of PCDD/Fs from fish''' describes the exposure to polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) due to fish consumption in the [[Benefit-risk assessment of fish consumption for Beneris#Beneris population|Beneris population]]. | |||
<br> | |||
=== | == Definition == | ||
Intake of PCDD/F from fish in Beneris is represented as a continuous variable and is indexed by variable age. It applies to the whole Beneris population (all age groups 0-2yr, 2-18yr, 18-55yr and 55yr+) and to indicators such as remaining lifetime risk of cancer in adults and risk of developmental dental defects.<br> | |||
=== Causality === | |||
List of parents: | |||
== Result == | *[[Concentrations of PCDD/Fs in fish|Concentrations of PCDD/Fs in fish]] | ||
*[[Domestic fish consumption of the general population in Finland|Domestic fish consumption of the general population in Finland]] | |||
*[[Body weight in Finland|Body weight in Finland]] | |||
=== Data === | |||
'''Lifetime cancer risk''' associated with PCDD/Fs is usually estimated using cancer slope factor (CSF) and the lifetime average daily dose (LADD). Therefore, in this case the intake of PCDD/Fs from fish is expressed as LADD. LADD is calculated as a product of average daily dose (ADD) and the ratio of exposure duration and averaging time (=life expectancy at birth), where ADD is the product of average WHO-TEQ concentration of PCDD/Fs in fish and fish intake rate (daily intake of fish) divided by the body weight. | |||
It is assumed that the exposure duration for people from a given age group is the number of years this age group covers. In other words it is assumed that people from a given age group are exposed to PCDD/Fs from the time of entry to this age group until the time of exit from this age group. Therefore, the exposure duration for age group 18-55yr is 37 years and it's 45 years for age group 55yr+ (assuming max age of 100 years). <br> | |||
Moreover, according to the WHO statistics <ref> World Health Statistics 2008, http://www.terkko.helsinki.fi/english/who/terkkomaterials.htm </ref> the life expectancy at birth in 2006 was 83 and 76 years for Finnish women and men, respectively, and the combined life expectancy was 79 years. | |||
To evaluate '''non-cancer risks''' the average daily dose (ADD) of PCDD/Fs is used. For children, the ADD of PCDD/Fs from fish is estimated as a product of daily fish consumption and | |||
the average WHO-TEQ concentration of PCDD/Fs in fish divided by the body weight. | |||
=== Formula === | |||
General formulas (omitting unit conversions): <br> | |||
ADD_species(i)=Average_WHO-TEQ_PCDD/Fs_concentration_species(i)*Daily_consumption_species(i)/BW <br> | |||
LADD_species(i)=Average_WHO-TEQ_PCDD/Fs_concentration_species(i)*Daily_consumption_species(i)*Exposure_duration/(BW*Life_expectancy_at_birth) | |||
=== Unit === | |||
'''ADD''': pg WHO-TEQ/kg bw-day <br> | |||
'''LADD''': mg/kg bw-day | |||
== See also == | |||
[http://www.norden.org/pub/sk/showpub.asp?pubnr=2008:531&lang=1 TemaNord report on PCDD/F and PCB in Nordic countries] | |||
== Result == | |||
Latest revision as of 10:00, 29 September 2009
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Scope
Intake of PCDD/Fs from fish describes the exposure to polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) due to fish consumption in the Beneris population.
Definition
Intake of PCDD/F from fish in Beneris is represented as a continuous variable and is indexed by variable age. It applies to the whole Beneris population (all age groups 0-2yr, 2-18yr, 18-55yr and 55yr+) and to indicators such as remaining lifetime risk of cancer in adults and risk of developmental dental defects.
Causality
List of parents:
- Concentrations of PCDD/Fs in fish
- Domestic fish consumption of the general population in Finland
- Body weight in Finland
Data
Lifetime cancer risk associated with PCDD/Fs is usually estimated using cancer slope factor (CSF) and the lifetime average daily dose (LADD). Therefore, in this case the intake of PCDD/Fs from fish is expressed as LADD. LADD is calculated as a product of average daily dose (ADD) and the ratio of exposure duration and averaging time (=life expectancy at birth), where ADD is the product of average WHO-TEQ concentration of PCDD/Fs in fish and fish intake rate (daily intake of fish) divided by the body weight.
It is assumed that the exposure duration for people from a given age group is the number of years this age group covers. In other words it is assumed that people from a given age group are exposed to PCDD/Fs from the time of entry to this age group until the time of exit from this age group. Therefore, the exposure duration for age group 18-55yr is 37 years and it's 45 years for age group 55yr+ (assuming max age of 100 years).
Moreover, according to the WHO statistics [1] the life expectancy at birth in 2006 was 83 and 76 years for Finnish women and men, respectively, and the combined life expectancy was 79 years.
To evaluate non-cancer risks the average daily dose (ADD) of PCDD/Fs is used. For children, the ADD of PCDD/Fs from fish is estimated as a product of daily fish consumption and
the average WHO-TEQ concentration of PCDD/Fs in fish divided by the body weight.
Formula
General formulas (omitting unit conversions):
ADD_species(i)=Average_WHO-TEQ_PCDD/Fs_concentration_species(i)*Daily_consumption_species(i)/BW
LADD_species(i)=Average_WHO-TEQ_PCDD/Fs_concentration_species(i)*Daily_consumption_species(i)*Exposure_duration/(BW*Life_expectancy_at_birth)
Unit
ADD: pg WHO-TEQ/kg bw-day
LADD: mg/kg bw-day
See also
TemaNord report on PCDD/F and PCB in Nordic countries
Result
- ↑ World Health Statistics 2008, http://www.terkko.helsinki.fi/english/who/terkkomaterials.htm