Dose-response function of persistent pollutants
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Question
Dose-response function of persistent pollutants describes the cancer dose-responses of several pollutants in humans (lifetime risk due to lifetime exposure).
Answer
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Dose-response slope | |
Dieldrin | 16 |
Toxaphene | 1.1 |
Dioxin | 1.56E+005 |
PCB | 2 |
Rationale
Data
Potency of pollutants. Cancer slope factors (CSF) are used for cancer and Reference Dose (RfD) values are used for non-cancer endpoints. The data comes from the U.S.EPA. [1]
The response assessment is restricted to cancer endpoints, because it is the more sensitive endpoint.
Table. Cancer slope factors (CSF) for several pollutants.
CSF | |
Dieldrin | 16 |
Toxaphene | 1.1 |
Dioxin | 1.56E+005 |
PCB | 2 |
Causality
Upstream variables
- None
Unit
(mg/kg/d)-1
Formula
CSFs are directly used.
See also
References
- ↑ U.S.EPA. Guidance for Assessing Chemical Contaminant Data for Use in Fish Advisory. Volume 2: Risk Assessment and Fish Consumption Limits, 3rd Edition. 2000. Table 3-1. Open access Internet file Intranet file