ERF of methyl mercury on CVD risk in adults

Scope

ERF of methyl mercury on CVD risk in adults describes quantitative relationship between methyl mercury (MeHg) exposure and risk of cardiovascular disease (CVD) in adults.

Definition

ERF of methyl mercury on CVD risk in adults is indexed by age variable. It applies to the last two age categories, i.e. 18-55yr and 55yr+.

Data

Virtanen et al ^[1] found that every microgram/gram of mercury in adult men hair increases (on average) the risk of CVD death by 10% (95% CI: 2% to 19%) and the risk of CHD death by 13% (95% CI: 3% to 23%). Based on this information a uniform distribution on interval [10%, 13%] has been chosen to describe the ERF of MeHg on risk of death from CVD in adults.

Causality

Unit

% change in risk / 1 ug/g of MeHg in hair

Formula

Result

mean %change = 11.5

References

↑ Jyrki K. Virtanen, Sari Voutilainen, Tiina H. Rissanen, Jaakko Mursu, Tomi-Pekka Tuomainen, Maarit J. Korhonen, Veli-Pekka Valkonen, Kari Seppanen, Jari A. Laukkanen, Jukka T. Salonen. Mercury, fish oils, and risk of acute coronary events and cardiovascular disease, coronary heart disease, and all-cause mortality in men in Eastern Finland. Arterioscler. Thromb. Vasc. Biol. 25 (2005), p.228-233.

[1] Jyrki K. Virtanen, Sari Voutilainen, Tiina H. Rissanen, Jaakko Mursu, Tomi-Pekka Tuomainen, Maarit J. Korhonen, Veli-Pekka Valkonen, Kari Seppanen, Jari A. Laukkanen, Jukka T. Salonen. Mercury, fish oils, and risk of acute coronary events and cardiovascular disease, coronary heart disease, and all-cause mortality in men in Eastern Finland. Arterioscler. Thromb. Vasc. Biol. 25 (2005), p.228-233.

[1]