ERF of PFAS

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Question

What are the exposure-response functions (ERF) of perfluorinated alkyl substances (PFAS) on several health endpoints?

Rationale

Data

ERF of PFAS(-)

Obs	Exposure agent	Response	Exposure	Exposure unit	ER function	Scaling	Threshold	ERF	Description
1	PFAS	PFAS TWI	Maternal exposure via ingestion	ng /kg /wk	TWI	BW	0	4.4	EFSA 2020
2	PFAS	Immunosuppression	Maternal ingested intake	ng /kg /wk	ERS	BW	0	0-0.0454	Converted from the row above assuming linearity and steady state
3	PFAS	Cholesterol increase	Ingestion	ng /kg /wk	ERS	BW	0	0	EFSA?
4	PFAS	Decreased birth weight	Ingestion	ng /kg /wk	ERS	BW	0	0	EFSA?
5	PFAS	Increased ALT	Ingestion	ng /kg /wk	ERS	BW	0	0	EFSA?

Immunosuppression is not well quantified. Here we assume that at the tolerable weekly intate (TWI) level, 0-20 % of respiratory infections are attributable to PFAS. Although age is not specified in the table, PFAS exposure is highest in infants due to pregnancy and breast feeding. Therefore we assume that immunosuppression occurs mainly at ages 0-9 a. The TWI comes from EFSA.

Calculations

Initiation 2021-01-29

+ Show code- Hide code # This is code Op_en7974/ERF_pfas on page [[ERF of PFAS]] # Note! This version has ERF and threshold in the same ovariable. library(OpasnetUtils) ERF_pfas <- Ovariable("ERF_pfas", ddata = "Op_en7974") colnames(ERF_pfas@data) <- gsub(" ", "_", colnames(ERF_pfas@data)) objects.store(ERF_pfas) cat("Ovariable ERF_pfas stored.\n")