Lateral chlorines

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Lateral chlorines: the four chlorine atoms in a PCDD/F molecule in positions 2, 3, 7, and 8. These four chlorines are required for binding to the AH receptor and toxic effects. They also stabilise the molecule against metabolism, which increases their half-life and tendency for accumulation. PCDD/Fs without lateral chlorines are rapidly metabolised, which prevents their accumulation in the food chain.