Multistage model: Difference between revisions

Revision as of 07:29, 27 March 2008

The multistage model is a dose-response model that attempts to reflect the biological process of carcinogenesis.

P(Response|Dose)= background +(1-background)*(1-exp(-q1*Dose -q2*Dose^2 -q3*Dose^3...))

A more simple

the formula for (excess) risk is:

P(dose) = 1 - exp [-alfao +alfa1 *

dose1 +...alfak * dose]

(alfa=dose-response)

At

risk levels (<10-2) the following linear formula can be used for the upper bound (95%) risk

Risk = exposure (mg/kg/day) * q1 (risk per mg/kg/day)

q1=cancer slope factor, upper 95% confidence limit,

calculated from 10% point of departure (POD)

from experimental data

See e.g. Casarett & Doull's Toxicology

, 6th ed. 2001, p. 95-97.

@@ Line 1: / Line 1: @@
-The [[multistage model]] is a dose-response model that attempts to reflect the biological process of carcinogenesis.
+The '''multistage model''' is a dose-response model that attempts to reflect the biological process of carcinogenesis.
 P(Response|Dose)= background +(1-background)*(1-exp(-q1*Dose -q2*Dose^2 -q3*Dose^3...))
-[[Category:Health effects]]
-[[Category:Needs editing]]
+A more simple&nbsp;
+the formula for (excess) risk is:
+P(dose) = 1 - exp [-alfao +alfa1 *
+dose1 +...alfak * dose]
+(alfa=dose-response)
+At
+risk levels (&lt;10-2) the following linear formula can be used for the upper bound (95%) risk
+Risk = exposure (mg/kg/day) * q1 (risk per mg/kg/day)
+q1=cancer slope factor, upper 95% confidence limit,
+calculated from 10% point of departure (POD)
+from experimental data
+See e.g. Casarett &amp; Doull's Toxicology
+&nbsp;, 6th ed. 2001, p. 95-97.
+[[Category:Health_effects]] [[Category:Needs_editing]]