ERF of PFAS: Difference between revisions

Revision as of 04:06, 26 February 2021

This page is a knowledge crystal of subtype variable. The page identifier is Op_en7974
Moderator:Jouni (see all)

Upload data {{#opasnet_base_link:Op_en7974}}

**Progression class**
In Opasnet many pages being worked on and are in different classes of progression. Thus the information on those pages should be regarded with consideration. The progression class of this page has been assessed: This page is a draft The relevat content and structure of the page is already present, but there still is a lot of missing content.	This page needs a curator. Learn more about curating Opasnet pages. The quality was last checked: 2021-01-29.

Question

What are the exposure-response functions (ERF) of perfluorinated alkyl substances (PFAS) on several health endpoints?

Answer

Rationale

Data

ERF of PFAS: Difference between revisions(-)
Obs	Exposure agent	Response	Exposure	Exposure unit	ER function	Scaling	ERF	Description
1	PFAS	PFAS TWI	Maternal exposure via ingestion	ng /kg /wk	TWI	BW	4.4	EFSA 2020
2	PFAS	Immunosuppression	Maternal ingested intake	ng /kg /wk	ERS	BW	0-0.0454	Converted from the row above assuming linearity and steady state
3	PFAS	Cholesterol increase	Ingestion	ng /kg /wk	ERS	BW	0	EFSA?
4	PFAS	Decreased birth weight	Ingestion	ng /kg /wk	ERS	BW	0	EFSA?
5	PFAS	Increased ALT	Ingestion	ng /kg /wk	ERS	BW	0	EFSA?

Immunosuppression is not well quantified. Here we assume that at the tolerable weekly intate (TWI) level, 0-20 % of respiratory infections are attributable to PFAS. Although age is not specified in the table, PFAS exposure is highest in infants due to pregnancy and breast feeding. Therefore we assume that immunosuppression occurs mainly at ages 0-9 a. The TWI comes from EFSA^[1].

Calculations

Initiation 2021-01-29

+ Show code - Hide code

# This is code Op_en7974/ERF_pfas on page [[ERF of PFAS]]
# Note! This version has ERF and threshold in the same ovariable.

library(OpasnetUtils)

ERF_pfas <- Ovariable("ERF_pfas", ddata = "Op_en7974")
colnames(ERF_pfas@data) <- gsub(" ", "_", colnames(ERF_pfas@data))

objects.store(ERF_pfas)
cat("Ovariable ERF_pfas stored.\n")

References

↑ EFSA. (2020) Risk to human health related to the presence of perfluoroalkyl substances in food. https://doi.org/10.2903/j.efsa.2020.6223

[1] EFSA. (2020) Risk to human health related to the presence of perfluoroalkyl substances in food. https://doi.org/10.2903/j.efsa.2020.6223

[1]

@@ Line 21: / Line 21: @@
 <t2b index="Exposure agent,Response,Exposure,Exposure unit,ER function,Scaling,Observation" locations="Threshold,ERF" desc="Description" unit="-">
 PFAS|PFAS TWI|Maternal exposure via ingestion|ng /kg /wk|TWI|BW|0|4.4|EFSA 2020
-PFAS|Immunosuppression|Maternal ingested intake|ng /kg /wk|ERS|BW|0|0.0227|Converted from the row above assuming linearity and steady state
+PFAS|Immunosuppression|Maternal ingested intake|ng /kg /wk|ERS|BW|0|0-0.0454|Converted from the row above assuming linearity and steady state
 PFAS|Cholesterol increase|Ingestion|ng /kg /wk|ERS|BW|0|0|EFSA?
 PFAS|Decreased birth weight|Ingestion|ng /kg /wk|ERS|BW|0|0|EFSA?
@@ Line 27: / Line 27: @@
 </t2b>
-Immunosuppression is not well quantified. Here we assume that at the tolerable weekly intate (TWI) level, 10 % of respiratory infections are attributable to PFAS. The TWI comes from EFSA<ref>EFSA. (2020) Risk to human health related to the presence of perfluoroalkyl substances in food. https://doi.org/10.2903/j.efsa.2020.6223</ref>.
+Immunosuppression is not well quantified. Here we assume that at the tolerable weekly intate (TWI) level, 0-20 % of respiratory infections are attributable to PFAS. Although age is not specified in the table, PFAS exposure is highest in infants due to pregnancy and breast feeding. Therefore we assume that immunosuppression occurs mainly at ages 0-9 a. The TWI comes from EFSA<ref>EFSA. (2020) Risk to human health related to the presence of perfluoroalkyl substances in food. https://doi.org/10.2903/j.efsa.2020.6223</ref>.
 === Calculations ===