ERF of PFAS

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Question

What are the exposure-response functions (ERF) of perfluorinated alkyl substances (PFAS) on several health endpoints?

Rationale

Data

ERF of PFAS: Difference between revisions(-)

Obs	Exposure agent	Response	Exposure	Exposure unit	ER function	Scaling	Threshold	ERF	Description
1	PFAS	PFAS TWI	Maternal exposure via ingestion	ng /kg /wk	TWI	BW	0	4.4	EFSA 2020
2	PFAS	Immunosuppression	Maternal ingested intake	ng /kg /wk	ERS	BW	0	0.0227	Converted from the row above assuming linearity and steady state
3	PFAS	Cholesterol increase	Ingestion	ng /kg /wk	ERS	BW	0	0	EFSA?
4	PFAS	Decreased birth weight	Ingestion	ng /kg /wk	ERS	BW	0	0	EFSA?
5	PFAS	Increased ALT	Ingestion	ng /kg /wk	ERS	BW	0	0	EFSA?

Immunosuppression is not well quantified. Here we assume that at the tolerable weekly intate (TWI) level, 10 % of respiratory infections are attributable to PFAS. The TWI comes from EFSA.

Calculations

Initiation 2021-01-29

+ Show code- Hide code # This is code Op_en7974/ERF_pfas on page [[ERF of PFAS]] # Note! This version has ERF and threshold in the same ovariable. library(OpasnetUtils) ERF_pfas <- Ovariable("ERF_pfas", ddata = "Op_en7974") colnames(ERF_pfas@data) <- gsub(" ", "_", colnames(ERF_pfas@data)) objects.store(ERF_pfas) cat("Ovariable ERF_pfas stored.\n")