ERF of PFAS: Difference between revisions
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<rcode name="ERF_pfas" label="Initiate ERF_pfas" embed=1> | <rcode name="ERF_pfas" label="Initiate ERF_pfas" embed=1> | ||
# This is code | # This is code Op_en7974/ERF_pfas on page [[ERF of PFAS]] | ||
# Note! This version has ERF and threshold in the same ovariable. | # Note! This version has ERF and threshold in the same ovariable. | ||
Revision as of 20:20, 25 January 2021
Moderator:Jouni (see all) |
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Question
What are the exposure-response functions (ERF) of perfluorinated alkyl substances (PFAS) on several health endpoints?
Answer
Rationale
Data
Obs | Exposure agent | Response | Exposure | Exposure unit | ER function | Scaling | Threshold | ERF | Description |
---|---|---|---|---|---|---|---|---|---|
1 | PFAS | PFAS TWI | Maternal exposure via ingestion | ng /kg /wk | TWI | BW | 0 | 4.4 | EFSA 2020 |
2 | PFAS | Immunosuppression | Maternal ingested intake | ng /kg /wk | ERS | BW | 0 | 0.0227 | Converted from the row above assuming linearity and steady state |
3 | PFAS | Cholesterol increase | Ingestion | ng /kg /wk | ERS | BW | 0 | 0 | EFSA? |
4 | PFAS | Decreased birth weight | Ingestion | ng /kg /wk | ERS | BW | 0 | 0 | EFSA? |
5 | PFAS | Increased ALT | Ingestion | ng /kg /wk | ERS | BW | 0 | 0 | EFSA? |