Point of departure: Difference between revisions
Jump to navigation
Jump to search
No edit summary |
No edit summary |
||
Line 2: | Line 2: | ||
<section begin=glossary /> | <section begin=glossary /> | ||
:'''Point of departure (POD)''' is a the point on a [[:en:Dose-response relationship|dose-response curve]] established from experimental data, e.g., the [[benchmark dose]], generally corresponding to an estimated low effect level (e.g., 1% to 10% incidence of an effect). Depending on the mode of action and available data, some form of extrapolation below the | :'''Point of departure (POD)''' is a the point on a [[:en:Dose-response relationship|dose-response curve]] established from experimental data, e.g., the [[benchmark dose]], generally corresponding to an estimated low effect level (e.g., 1% to 10% incidence of an effect). Depending on the mode of action and available data, some form of extrapolation below the POD may be employed for low-dose risk assessment or the POD may be divided by a series of uncertainty factors to arrive at a reference dose.<ref name="WHO report">[http://www.who.int/ipcs/methods/harmonization/draft_document_for_comment.pdf WHO Report]</ref> | ||
<section end=glossary /> | <section end=glossary /> | ||
Latest revision as of 16:09, 24 August 2009
This page is a encyclopedia article.
The page identifier is Op_en3630 |
---|
Moderator:Reetta (see all) |
|
Upload data
|
<section begin=glossary />
- Point of departure (POD) is a the point on a dose-response curve established from experimental data, e.g., the benchmark dose, generally corresponding to an estimated low effect level (e.g., 1% to 10% incidence of an effect). Depending on the mode of action and available data, some form of extrapolation below the POD may be employed for low-dose risk assessment or the POD may be divided by a series of uncertainty factors to arrive at a reference dose.[1]
<section end=glossary />