ERF of dioxin on cancer: Difference between revisions
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== Scope == | == Scope == | ||
'''ERF of dioxin on cancer '''describes the quantitative relationship between exposure to polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans (PCDD/Fs) and cancer risk in | '''ERF of dioxin on cancer '''describes the quantitative relationship between exposure to polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans (PCDD/Fs) and remaining lifetime cancer risk in adult Beneris population.<br> | ||
== Definition == | == Definition == | ||
ERF of dioxin on cancer is indexed by variable age. It applies to the last two age categories, i.e. 18-55yr and 55yr+. | ERF of dioxin on cancer is indexed by variable age. It applies to the last two age categories, i.e. 18-55yr and 55yr+ (gender combined). | ||
=== Causality === | === Causality === | ||
Revision as of 10:41, 29 September 2009
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Scope
ERF of dioxin on cancer describes the quantitative relationship between exposure to polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans (PCDD/Fs) and remaining lifetime cancer risk in adult Beneris population.
Definition
ERF of dioxin on cancer is indexed by variable age. It applies to the last two age categories, i.e. 18-55yr and 55yr+ (gender combined).
Causality
Data
The U.S. Environmental Protection Agency (US EPA) calculated an oral cancer slope factor (CSF) for 2,3,7,8 - TCDD (the most toxic dioxin compound). This CFS equals to 156000 (mg/kg bw-d)-1 and represents the upper 95th percentile estimate of the probability of developing cancer per unit intake of chemical over a lifetime. [1]
Formula
Unit
(mg/kg bw/d)-1
Result
156000
References
- ↑ US EPA 2000. Guidance for assessing chemical contaminant data for use in fish advisories. Volume 1: Fish sampling and analysis, 3rd edition. http://www.epa.gov/waterscience/fish/advice/volume1/