Sandbox: Difference between revisions

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</math>
</math>
== ovariable merge testing ==
<rcode>
library(OpasnetUtils)
a <- new("ovariable", output = data.frame(dummy=NA))
b <- new("ovariable", output = data.frame(a=1:4))
merge(a,b)
</rcode>


== Static GoogleMaps test ==
== Static GoogleMaps test ==

Revision as of 11:28, 26 June 2012


http://ytoswww/yhteiset/YMAL/Projects/

Edited by ehac

Failed to parse (SVG (MathML can be enabled via browser plugin): Invalid response ("Math extension cannot connect to Restbase.") from server "https://wikimedia.org/api/rest_v1/":): {\displaystyle L_{Aeq} = 10 \log \int_{t_0}^{t_1} \frac{p_A^2(t)}{p_0^2} dt }


Failed to parse (SVG (MathML can be enabled via browser plugin): Invalid response ("Math extension cannot connect to Restbase.") from server "https://wikimedia.org/api/rest_v1/":): {\displaystyle \textstyle L_{Aeq} = 10 \log \int_{t_0}^{t_1} \frac{p_A^2(t)}{p_0^2} dt }

ovariable merge testing

+ Show code

Static GoogleMaps test

+ Show code


Kuopio buildings on Google maps test

Building minimum age:

+ Show code


GoogleMaps Sorvi MML TEST

+ Show code

GoogleMaps PostgreSQL test 2

+ Show code

GoogleMaps PostgreSQL test

+ Show code

Opasnet.csv test

+ Show code

Opasnet.data and BUGS test

+ Show code

+ Show code

Failed to parse (SVG (MathML can be enabled via browser plugin): Invalid response ("Math extension cannot connect to Restbase.") from server "https://wikimedia.org/api/rest_v1/":): {\displaystyle \alpha 444 + 9999 / 123}


Hello

  • this works

Bluebox

  • works
  • ok


R-tools code include example

+ Show code

Jatropan viljelyala (ha):

n:

Mitkä tekijät halua eritellä tuloksessa?:
Katalyytin määrä
Ikä
Kastelu
Käytetty puristin

Minkä yhden tekijän halua eritellä kuvaajassa?:

+ Show code

+ Show code

Rectangle area test

width:

Rect height:

+ Show code

 

Kristiina telmii

You have error(s) in your data:

You have invalid number of data cells in row 149

Sandbox: Difference between revisions(no unit)
ObsSubstanceCASRNWOE 86 GuidelinesWOE NarrativeIRIS identifier
1Acenaphthene83-32-9Not Assessed under the IRIS program.0442
2Acenaphthylene 208-96-8D, Not classifiable as to human carcinogenicityBased on no human data and inadequate data from animal bioassays.0443
3Acephate30560-19-1C, Possible human carcinogenThe classification is based on increased incidence of hepatocellular carcinomas and adenomas in female mice.0354
4Acetaldehyde75-07-0B2, Probable human carcinogen - based on sufficient evidence of carcinogenicity in animalsBased on increased incidence of nasal tumors in male and female rats and laryngeal tumors in male and female hamsters after inhalation exposure.0290
5Acetochlor34256-82-1Not Assessed under the IRIS program.0521
6Acetone67-64-1NA, Not applicable. This substance was not assessed using the 1986 cancer guidelines (U.S. EPA, 1986).In accordance with the Draft Revised Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1999) data are inadequate for an assessment of the human carcinogenic potential of acetone.0128
7Acetonitrile75-05-8D, Not classifiable as to human carcinogenicityUnder the Proposed Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1996), the carcinogenic potential of ACN following inhalation, oral, or dermal exposure is best characterized as "cannot be determined because the existing evidence is composed of conflicting data (e.g., some evidence is suggestive of carcinogenic effects, but other equally pertinent evidence does not confirm any concern)."0205
8Acetophenone98-86-2D, Not classifiable as to human carcinogenicityBased on no human data and no animal data.0321
9Acetyl chloride75-36-5D, Not classifiable as to human carcinogenicityNo human data or animal data.0518
10Acifluorfen, sodium62476-59-9Not Assessed under the IRIS program.0192
11Acrolein107-02-8NA, Not applicable. This substance was not assessed using the 1986 cancer guidelines (U.S. EPA, 1986).Under the Draft Revised Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1999), the potential carcinogenicity of acrolein cannot be determined because the existing data are inadequate for an assessment of human carcinogenic potential for either the oral or inhalation route of exposure. There are no adequate human studies of the carcinogenic potential of acrolein. Collectively, experimental studies provide inadequate evidence that acrolein causes cancer in laboratory animals.0364
12Acrylamide79-06-1B2, Probable human carcinogen - based on sufficient evidence of carcinogenicity in animalsBased on inadequate human data and sufficient evidence of carcinogenicity in animals; significantly increased incidences of benign and/or malignant tumors at multiple sites in both sexes of rats, and carcinogenic effects in a series of one-year limited bioassays in mice by several routes of exposures. The classification is supported by positive genotoxicity data, adduct formation activity, and structure-activity relationships to vinyl carbamate and acrylonitrile.0286
13Acrylic acid79-10-7Not Assessed under the IRIS program.0002
14Acrylonitrile107-13-1B1, Probable human carcinogen - based on limited evidence of carcinogenicity in humansThe observation of a statistically significant increase in incidence of lung cancer in exposed workers and observation of tumors, generally astrocytomas in the brain, in studies in two rat strains exposed by various routes (drinking water, gavage, and inhalation) forms the basis for this classification.0206
15Adiponitrile111-69-3D, Not classifiable as to human carcinogenicityNo human and no animal cancer data were available. Adiponitrile was negative for mutagenicity in Salmonella with and without activation.0515
16Alachlor15972-60-8Not Assessed under the IRIS program.0129
17Alar1596-84-5Not Assessed under the IRIS program.0287
18Aldicarb116-06-3D, Not classifiable as to human carcinogenicityAldicarb was not found to induce statistically significant increases in tumor incidence in mice or rats in feeding studies or mice in a skin painting study. In the feeding studies there were, however, significant trends in pituitary tumors in female rats and fibrosarcomas in the male mouse. This evidence, together with the fact that less than maximum tolerated doses were used, indicates that the available assays are inadequate to assess the carcinogenic potential of aldicarb.0003
19Aldicarb sulfone1646-88-4Not Assessed under the IRIS program.0312
20Aldrin309-00-2B2, Probable human carcinogen - based on sufficient evidence of carcinogenicity in animalsOrally administered aldrin produced significant increases in tumor responses in three different strains of mice in both males and females. Tumor induction has been observed for structurally related chemicals, including dieldrin, a metabolite.0130
21Ally74223-64-6Not Assessed under the IRIS program.0288
22Allyl alcohol107-18-6Not Assessed under the IRIS program.0004
23Allyl chloride107-05-1C, Possible human carcinogenClassification is based on a low (but biologically important) incidence of forestomach tumors in female mice and positive results in a variety of genetic toxicity tests. Allyl chloride is an alkylating agent and structurally related to probable human carcinogens.0387
24Aluminum phosphide20859-73-8Not Assessed under the IRIS program.0005
25Amdro67485-29-4Not Assessed under the IRIS program.0207
26Ametryn834-12-8Not Assessed under the IRIS program.0208
274-Aminopyridine504-24-5D, Not classifiable as to human carcinogenicityNo human data and no animal data available.0440
28Amitraz33089-61-1Not Assessed under the IRIS program.0334
29Ammonia7664-41-7Not Assessed under the IRIS program.0422
30Ammonium acetate631-61-8D, Not classifiable as to human carcinogenicityNo human data and no animal data0517
31Ammonium methacrylate16325-47-6D, Not classifiable as to human carcinogenicityNo human data and no animal data0516
32Ammonium sulfamate7773-06-0Not Assessed under the IRIS program.0007
33Aniline62-53-3B2, Probable human carcinogen - based on sufficient evidence of carcinogenicity in animalsInduction of tumors of the spleen and the body cavity in two strains of rat, and some supporting genetic toxicological evidence.0350
34ortho-Anisidine90-04-0Not Assessed under the IRIS program.0610
35Anthracene120-12-7D, Not classifiable as to human carcinogenicityBased on no human data and inadequate data from animal bioassays.0434
36Antimony7440-36-0Not Assessed under the IRIS program.0006
37Antimony trioxide1309-64-4Not Assessed under the IRIS program.0676
38Apollo74115-24-5C, Possible human carcinogenBased on an increase in thyroid gland follicular cell tumors in male rats and supportive findings in pituitary/thyroid hormone activity.0008
39Aramite140-57-8B2, Probable human carcinogen - based on sufficient evidence of carcinogenicity in animalsBased on no human data and sufficient data from animal bioassays including increased incidence of liver tumors and/or neoplastic nodules in three strains of male and female rats and males of one strain of mice, and extrahepatic biliary system tumors in dogs following chronic oral exposure.0473
40Aroclor 101612674-11-2Not Assessed under the IRIS program.0462
41Aroclor 124812672-29-6Not Assessed under the IRIS program.0649
42Aroclor 125411097-69-1Not Assessed under the IRIS program.0389
43Arsenic, inorganic7440-38-2A, Human Carcinogen Based on sufficient evidence from human data. An increased lung cancer mortality was observed in multiple human populations exposed primarily through inhalation. Also, increased mortality from multiple internal organ cancers (liver, kidney, lung, and bladder) and an increased incidence of skin cancer were observed in populations consuming drinking water high in inorganic arsenic.0278
44Arsine7784-42-1Not Assessed under the IRIS program.0672
45Asbestos1332-21-4A, Human CarcinogenObservation of increased mortality and incidence of lung cancer, mesotheliomas and gastrointestinal cancer in occupationally exposed workers are consistent across investigators and study populations. Animal studies by inhalation in two strains of rats showed similar findings for lung cancer and mesotheliomas. Animal evidence for carcinogenicity via ingestion is limited (male rats fed intermediate-range chrysotile fibers; i.e., >10 um length, developed benign polyps), and epidemiologic data in this regard are inadequate.0371
46Assure76578-14-8D, Not classifiable as to human carcinogenicityBased on no human data and inadequate animal data.0335
47Asulam3337-71-1Not Assessed under the IRIS program.0284
48Atrazine1912-24-9Not Assessed under the IRIS program.0209
49Avermectin B165195-55-3Not Assessed under the IRIS program.0381
50Azobenzene103-33-3B2, Probable human carcinogen - based on sufficient evidence of carcinogenicity in animalsAzobenzene induced invasive sarcomas in the spleen and other abdominal organs in male and female F344 rats following dietary administration. It is genotoxic and may be converted to benzidine, a known human carcinogen, under the acidic conditions in the stomach.0351
51Barium and Compounds7440-39-3D, Not classifiable as to human carcinogenicityUnder the Proposed Guidelines for Carcinogenic Risk Assessment (U.S. EPA, 1996), barium is considered not likely to be carcinogenic to humans following oral exposure and its carcinogenic potential cannot be determined following inhalation exposure.0010
52Barium cyanide542-62-1Not Assessed under the IRIS program.0009
53Baygon114-26-1Not Assessed under the IRIS program.0210
54Bayleton43121-43-3Not Assessed under the IRIS program.0131
55Baythroid68359-37-5Not Assessed under the IRIS program.0132
56Benefin1861-40-1Not Assessed under the IRIS program.0133
57Benomyl17804-35-2Not Assessed under the IRIS program.0011
58Bentazon (Basagran)25057-89-0E, Evidence of non-carcinogenicity for humansUnder EPA's proposed guidelines for carcinogen risk assessment (U.S. EPA, 1996), Bentazon would be characterized as not likely to be carcinogenic to humans by any route of exposure.0134
59Benz[a]anthracene56-55-3B2, Probable human carcinogen - based on sufficient evidence of carcinogenicity in animalsBased on no human data and sufficient data from animal bioassays. Benz[a]anthracene produced tumors in mice exposed by gavage; intraperitoneal, subcutaneous or intramuscular injection; and topical application. Benz[a]anthracene produced mutations in bacteria and in mammalian cells, and transformed mammalian cells in culture.0454
60Benzaldehyde100-52-7Not Assessed under the IRIS program.0332
61Benzene71-43-2A, Human CarcinogenUnder the proposed revised Carcinogen Risk Assessment Guidelines (U.S. EPA, 1996), benzene is characterized as a known human carcinogen for all routes of exposure based upon convincing human evidence as well as supporting evidence from animal studies. (U.S. EPA, 1979, 1985, 1998; ATSDR, 1997).0276
62Benzidine92-87-5A, Human CarcinogenObservation of increased incidence of bladder cancer and bladder cancer-related deaths in exposed workers0135
63Benzo[a]pyrene (BaP)50-32-8B2, Probable human carcinogen - based on sufficient evidence of carcinogenicity in animalsHuman data specifically linking benzo[a]pyrene (BAP) to a carcinogenic effect are lacking. There are, however, multiple animal studies in many species demonstrating BAP to be carcinogenic following administration by numerous routes. BAP has produced positive results in numerous genotoxicity assays.0136
64Benzo[b]fluoranthene205-99-2B2, Probable human carcinogen - based on sufficient evidence of carcinogenicity in animalsBased on no human data and sufficient data from animal bioassays. Benzo[b]fluoranthene produced tumors in mice after lung implantation, intraperitoneal (i.p.) or subcutaneous (s.c.) injection, and skin painting.0453
65Benzo[g,h,i]perylene191-24-2D, Not classifiable as to human carcinogenicityBased on no human data and inadequate animal data from lung implant, skin-painting and subcutaneous injection bioassays.0461
66Benzo[k]fluoranthene207-08-9B2, Probable human carcinogen - based on sufficient evidence of carcinogenicity in animalsBased on no human data and sufficient data from animal bioassays. Benzo[k]fluoranthene produced tumors after lung implantation in mice and when administered with a promoting agent in skin-painting studies. Equivocal results have been found in a lung adenoma assay in mice. Benzo[k]fluoranthene is mutagenic in bacteria.0452
67Benzoic acid65-85-0D, Not classifiable as to human carcinogenicityNo human data and inadequate data from animal bioassays0355
68Benzotrichloride98-07-7B2, Probable human carcinogen - based on sufficient evidence of carcinogenicity in animalsBased on inadequate human data and sufficient evidence of carcinogenicity in animals; namely, significantly increased incidences of benign and malignant tumors at multiple sites in one strain of female mice treated orally, dermally, and by inhalation. There is also evidence of mutagenicity in a variety of test systems.0388
69Benzyl chloride100-44-7B2, Probable human carcinogen - based on sufficient evidence of carcinogenicity in animalsBased on inadequate human data and sufficient evidence of carcinogenicity in animals; namely significantly increased incidences of benign and malignant tumors at multiple sites in both sexes of mice and a significant increase in thyroid tumors in female rats. There was evidence of mutagenicity in a variety of test systems.0393
70Beryllium and compounds7440-41-7B1, Probable human carcinogen - based on limited evidence of carcinogenicity in humansUsing the 1996 proposed Guidelines for Carcinogen Risk Assessment, inhaled beryllium would be characterized as a "likely" carcinogen in humans, and the human carcinogenic potential of ingested beryllium cannot be determined.0012
71Bidrin141-66-2Not Assessed under the IRIS program.0211
72Biphenthrin82657-04-3Not Assessed under the IRIS program.0333
731,1-Biphenyl92-52-4D, Not classifiable as to human carcinogenicityNo human data and inadequate studies in mice and rats. Results of genotoxicity tests are generally negative.0013
74Bis(2-chloro-1-methylethyl) ether108-60-1Not Assessed under the IRIS program.0407
75Bis(2-chloroethoxy)methane111-91-1D, Not classifiable as to human carcinogenicityNo human data and no animal data.0522
76Bis(chloroethyl)ether (BCEE)111-44-4B2, Probable human carcinogen - based on sufficient evidence of carcinogenicity in animalsPositive carcinogenicity results in two strains of mice and evidence of mutagenicity0137
77Bis(chloromethyl)ether (BCME)542-88-1A, Human CarcinogenStatistically significant increases in lung tumors (oat cell carcinomas) observed in six studies of exposed workers and bioassay data from rats and mice.0375
78Bisphenol A.80-05-7Not Assessed under the IRIS program.0356
79Boron and Compounds7440-42-80410
80Bromate15541-45-4B2, Probable human carcinogen - based on sufficient evidence of carcinogenicity in animalsUnder the Proposed Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1996), Bromate should be evaluated as a likely human carcinogen by the oral route of exposure. Insufficient data are available to evaluate the human carcinogenic potential of Bromate by the inhalation route.1002
81Brominated dibenzofuransNAD, Not classifiable as to human carcinogenicityNo data in humans or animals0514
82Bromobenzene108-86-11020
83Bromochloromethane74-97-5D, Not classifiable as to human carcinogenicityBased on the lack of data regarding the carcinogenicity of bromochloromethane in humans or animals; however, there are data indicative of genotoxic effects and structural relationships to halogenated methanes classified as B2 probable human carcinogens.0532
84Bromodichloromethane75-27-4B2, Probable human carcinogen - based on sufficient evidence of carcinogenicity in animalsBased on inadequate human data and sufficient evidence of carcinogenicity in two animal species (mice and rats) as shown by increased incidence of kidney tumors and tumors of the large intestine in male and female rats, kidney tumors in male mice, and liver tumors in female mice.0213
85p-Bromodiphenyl ether101-55-3D, Not classifiable as to human carcinogenicityNo human data and inadequate animal data.0490
86Bromoform75-25-2B2, Probable human carcinogen - based on sufficient evidence of carcinogenicity in animalsBased on inadequate human data and sufficient evidence of carcinogenicity in animals, namely an increased incidence of tumors after oral administration of bromoform in rats and intraperitoneal administration in mice. Bromoform is genotoxic in several assay systems. Also, bromoform is structurally related to other trihalomethanes (e.g., chloroform, bromodichloromethane, dibromochloromethane) which have been verified as either probable or possible carcinogens.0214
87Bromomethane74-83-9D, Not classifiable as to human carcinogenicityInadequate human and animal data: a single mortality study from which direct exposure associations could not be deduced and studies in several animal species with too few animals, too brief exposure or observation time for adequate power. Bromomethane has shown genotoxicity.0015
88Bromotrichloromethane75-62-7D, Not classifiable as to human carcinogenicityBased on no data regarding the carcinogenicity of bromotrichloromethane in humans or animals.0533
89Bromoxynil1689-84-5Not Assessed under the IRIS program.0289
90Bromoxynil octanoate1689-99-2Not Assessed under the IRIS program.0138
911,3-Butadiene106-99-0NA, Not applicable. This substance was not assessed using the 1986 cancer guidelines (U.S. EPA, 1986).Under EPA's 1999 Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1999), 1,3-butadiene is characterized as carcinogenic to humans by inhalation. This characterization is supported by the total weight of evidence provided by the following: (1) sufficient evidence from epidemiologic studies of the majority of U.S. workers occupationally exposed to 1,3-butadiene, either to the monomer or to the polymer by inhalation, showing increased lymphohematopoietic cancers and a dose-response relationship for leukemias in polymer workers (see Section II.A.2), (2) sufficient evidence in laboratory animal studies showing that 1,3-butadiene causes tumors at multiple sites in mice and rats by inhalation (see Section II.A.3), and (3) numerous studies consistently demonstrating that 1,3-butadiene is metabolized into genotoxic metabolites by experimental animals and humans (see Section II.A.4). The specific mechanisms of 1,3-butadiene-induced carcinogenesis are unknown; however, the scientific evidence strongly suggests that the carcinogenic effects are mediated by genotoxic metabolites of 1,3-butadiene, i.e., the monoepoxide, the diepoxide, and the epoxydiol.0139
92n-Butanol71-36-3D, Not classifiable as to human carcinogenicityBased on no human and no animal cancer data.0140
93Butyl benzyl phthalate85-68-7C, Possible human carcinogenBased on statistically significant increase in mononuclear cell leukemia in female rats; the response in male rats was inconclusive and there was no such response in mice.0293
94Butylate2008-41-5Not Assessed under the IRIS program.0215
95t-Butylchloride507-20-0D, Not classifiable as to human carcinogenicityBased on no human carcinogenicity data and inadequate animal data.0417
96Butylphthalyl butylglycolate (BPBG)85-70-1Not Assessed under the IRIS program.0016
97Cacodylic acid75-60-5D, Not classifiable as to human carcinogenicityNo human data and inadequate data in animals0587
98Cadmium7440-43-9B1, Probable human carcinogen - based on limited evidence of carcinogenicity in humansLimited evidence from occupational epidemiologic studies of cadmium is consistent across investigators and study populations. There is sufficient evidence of carcinogenicity in rats and mice by inhalation and intramuscular and subcutaneous injection. Seven studies in rats and mice wherein cadmium salts (acetate, sulfate, chloride) were administered orally have shown no evidence of carcinogenic response.0141
99Calcium cyanide592-01-8Not Assessed under the IRIS program.0017
100Caprolactam105-60-2Not Assessed under the IRIS program.0357
101Captafol2425-06-1Not Assessed under the IRIS program.0216
102Captan133-06-2Not Assessed under the IRIS program.0018
103Carbaryl63-25-2Not Assessed under the IRIS program.0019
104Carbofuran1563-66-2Not Assessed under the IRIS program.0218
105Carbon disulfide75-15-0Not Assessed under the IRIS program.0217
106Carbon tetrachloride56-23-5B2, Probable human carcinogen - based on sufficient evidence of carcinogenicity in animalsCarcinogenicity in rats, mice, and hamsters0020
107Carbonyl sulfide463-58-1Not Assessed under the IRIS program.0617
108Carbosulfan55285-14-8Not Assessed under the IRIS program.0021
109Carboxin5234-68-4Not Assessed under the IRIS program.0022
110Cerium Oxide and Cerium Compounds1306-38-31018
111Chloral hydrate302-17-0C, Possible human carcinogenUnder the 1996 proposed guidelines for carcinogen risk assessment (U.S. EPA, 1996), chloral hydrate shows suggestive evidence of human carcinogenicity by the oral route of exposure.0304
112Chloramben133-90-4Not Assessed under the IRIS program.0023
113Chlordane (Technical)12789-03-6B2, Probable human carcinogen - based on sufficient evidence of carcinogenicity in animalsUnder the 1996 Proposed Guidelines, chlordane would be characterized as a likely carcinogen by all routes of exposure.0142
114Chlordecone (Kepone)143-50-01017
115Chlorimuron-ethyl90982-32-4Not Assessed under the IRIS program.0406
116Chlorine7782-50-5Not Assessed under the IRIS program.0405
117Chlorine cyanide506-77-4Not Assessed under the IRIS program.0024
118Chlorine dioxide10049-04-4D, Not classifiable as to human carcinogenicityUnder the draft Carcinogen Assessment Guidelines (U.S. EPA, 1996), the human carcinogenicity of chlorine dioxide cannot be determined because no satisfactory human or animal studies assessing the chronic carcinogenic potential of chlorine dioxide have been located.0496
119Chlorite (sodium salt)7758-19-2D, Not classifiable as to human carcinogenicityUnder the draft Carcinogen Assessment Guidelines (U.S. EPA, 1996), the human carcinogenicity of chlorite cannot be determined because of a lack of human data and limitations in animal studies.0648
1201-Chloro-1,1-difluoroethane75-68-3Not Assessed under the IRIS program.0661
1212-Chloroacetophenone532-27-4Not Assessed under the IRIS program.0537
122p-Chloroaniline106-47-8Not Assessed under the IRIS program.0320
123Chlorobenzene108-90-7D, Not classifiable as to human carcinogenicityNo human data, inadequate animal data and predominantly negative genetic toxicity data in bacterial, yeast, and mouse lymphoma cells.0399
124Chlorobenzilate510-15-6Not Assessed under the IRIS program.0400
1251-Chlorobutane109-69-3D, Not classifiable as to human carcinogenicityBased on no human carcinogenicity data and inadequate animal data.0415
1262-Chlorobutane78-86-4D, Not classifiable as to human carcinogenicityBased on no human carcinogenicity data and inadequate animal data.0416
127Chlorocyclopentadiene41851-50-7D, Not classifiable as to human carcinogenicityLack of data concerning carcinogenicity in humans or animals.0430
128Chlorodifluoromethane75-45-6Not Assessed under the IRIS program.0657
129Chloroform67-66-3B2, Probable human carcinogen - based on sufficient evidence of carcinogenicity in animalsUnder the Proposed Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1996; U.S. EPA, 1999), chloroform is likely to be carcinogenic to humans by all routes of exposure under high-exposure conditions that lead to cytotoxicity and regenerative hyperplasia in susceptible tissues (U.S. EPA, 1998a,b). Chloroform is not likely to be carcinogenic to humans by any route of exposure under exposure conditions that do not cause cytotoxicity and cell regeneration. This weight-of-evidence conclusion is based on: 1) observations in animals exposed by both oral and inhalation pathways which indicate that sustained or repeated cytotoxicity with secondary regenerative hyperplasia precedes, and is probably required for, hepatic and renal neoplasia; 2) there are no epidemiological data specific to chloroform and, at most, equivocal epidemiological data related to drinking water exposures that cannot necessarily be negative, although there are some scattered positive results that generally have limitations such as excessively high dose or with confounding factors. Thus, the weigh-of-evidence of the genotoxicity data on chloroform supports a conclusion that chloroform is not strongly mutagenic, and the genotoxicity is not likely to be the predominant mode of action underlying the carcinogenic potential of chloroform. Although no cancer data exist for exposures via the dermal pathway, the weight-of-evidence conclusion is considered to be applicable to this pathway as well, because chloroform absorbed through the skin and into the blood is expected to be metabolized and to cause toxicity in much the same way as chloroform absorbed by other exposure routes.0025
130Chloromethyl methyl ether (CMME)107-30-2A, Human CarcinogenThe observation of an increased incidence of respiratory cancer in exposed workers and the observation of respiratory tumors in mice, rats, and hamsters exposed by inhalation forms the basis for this classification.0245
131beta-Chloronaphthalene91-58-7Not Assessed under the IRIS program.0463
1322-Chlorophenol95-57-8Not Assessed under the IRIS program.0303
133p-Chlorophenyl methyl sulfide123-09-1D, Not classifiable as to human carcinogenicityNo human or animal studies found in the available literature0623
134p-Chlorophenyl methyl sulfone98-57-7D, Not classifiable as to human carcinogenicityNo human or animal studies found in the available literature0624
135p-Chlorophenyl methyl sulfoxide934-73-6D, Not classifiable as to human carcinogenicityNo human or animal studies found in the available literature0625
136Chloroprene126-99-81021
137Chlorothalonil1897-45-6Not Assessed under the IRIS program.0143
138o-Chlorotoluene95-49-8Not Assessed under the IRIS program.0412
139Chlorpropham101-21-3Not Assessed under the IRIS program.0283
140Chlorpyrifos2921-88-2Not Assessed under the IRIS program.0026
141Chlorsulfuron64902-72-3Not Assessed under the IRIS program.0027
142Chromium(III), insoluble salts16065-83-1D, Not classifiable as to human carcinogenicityUsing the Proposed Guidelines for Carcinogen Risk Assessment (EPA, 1996), there are inadequate data to determine the potential carcinogenicity of trivalent chromium, as discussed below. However, the classification of hexavalent chromium as a known human carcinogen raises a concern for the carcinogenic potential of trivalent chromium.0028
143Chromium(VI)18540-29-9A, Human Carcinogen (Inhalation route)D, Not classifiable as to human carcinogenicity (Oral route)Under the proposed guidelines (EPA, 1996), Cr(VI) would be characterized as a known human carcinogen by the inhalation route of exposure. The oral carcinogenicity of Cr(VI) cannot be determined. No data were located in the available literature that suggested that Cr(VI) is carcinogenic by the oral route of exposure.0144
144Chrysene218-01-9B2, Probable human carcinogen - based on sufficient evidence of carcinogenicity in animalsNo human data and sufficient data from animal bioassays. Chrysene produced carcinomas and malignant lymphoma in mice after intraperitoneal injection and skin carcinomas in mice following dermal exposure. Chrysene produced chromosomal abnormalities in hamsters and mouse germ cells after gavage exposure, positive responses in bacterial gene mutation assays and transformed mammalian cells exposed in culture.0455
145Coke oven emissions8007-45-2A, Human CarcinogenStudies of coke oven workers have shown increased risk of mortality from cancer of the lung, trachea and bronchus; cancer of the kidney; cancer of the prostate; and cancer at all sites combined. In animals, extracts and condensates of coke oven emissions were found to be carcinogenic in both inhalation studies and skin-painting bioassays. The mutagenicity of whole extracts and condensates, as well as their individual components, provides supportive evidence for carcinogenicity.0395
146Copper7440-50-8D, Not classifiable as to human carcinogenicityThere are no human data, inadequate animal data from assays of copper compounds, and equivocal mutagenicity data.0368
147Copper cyanide544-92-3Not Assessed under the IRIS program.0029
148Creosote8001-58-9B1, Probable human carcinogen - based on limited evidence of carcinogenicity in humansLimited evidence of the association between occupational creosote contact and subsequent tumor formation, sufficient evidence of local and distant tumor formation after dermal application to mice, and some evidence of mutagenic activity, as well as the well-documented carcinogenicity of other coal tar products to humans.0360
149Crotonaldehyde123-73-9C, Possible human carcinogenBased on no human data and an increased incidence of hepatocellular carcinomas and hepatic neoplastic nodules (combined) in male F344 rats. The possible carcinogenicity of crotonaldehyde is supported by genotoxic activity and the expected reactivity of croton oil and aldehyde. Crotonaldehyde is also a suspected metabolite of N-nitrosopyrrolidine, a probable human carcinogen.