Decision analysis and risk management: Difference between revisions

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'''Statistics'''  
'''Statistics'''  


*[http://en.wikipedia.org/wiki/Descriptive_statistics list of links to some methods of descriptive statistics]  
*[http://en.wikipedia.org/wiki/Descriptive_statistics Descriptive statistics (Wikipedia)]  
*[http://en.wikipedia.org/wiki/Inferential_statistics list of links to many methods inferential statistics]  
*[http://en.wikipedia.org/wiki/Inferential_statistics Statistical inference (Wikipedia)]  
*[http://en.wikipedia.org/wiki/Sensitivity_analysis fairly thorough description of sensitivity analysis]  
*[http://en.wikipedia.org/wiki/Sensitivity_analysis Sensitivity analysis (Wikipedia)]  
*[http://en.wikipedia.org/wiki/Propagation_of_uncertainty thorough mathematical description of uncertainty propagation and covariance matrices; nothing about Monte Carlo]  
*[http://en.wikipedia.org/wiki/Propagation_of_uncertainty Propagation of uncertainty (Wikipedia)]  
*[http://en.wikipedia.org/wiki/Monte_Carlo_integration how to integrate with Monte Carlo; not necessary in risk assessment]  
*[http://en.wikipedia.org/wiki/Monte_Carlo_integration Monte Carlo integration (Wikipedia)]  
*[http://en.wikipedia.org/wiki/Calibrated_probability_assessment a short description of training in subjective probabilities]  
*[http://en.wikipedia.org/wiki/Calibrated_probability_assessment Calibrated probability assessment (Wikipedia)]  
*[[:en:Frequency probability|Frequency probability]]  
*[[:en:Frequency probability|Frequency probability (Wikipedia)]]  
*[[:en:Bayesian probability|Bayesian probability]]  
*[[:en:Bayesian probability|Bayesian probability (Wikipedia)]]  
*[[:en:Principle of maximum entropy|Principle of maximum entropy]]
*[[:en:Principle of maximum entropy|Principle of maximum entropy (Wikipedia)]]


'''Exposure'''  
'''Exposure'''  


*[http://en.wikipedia.org/wiki/Exposure_science only a stub]
*[http://en.wikipedia.org/wiki/Exposure_science Exposure science (Wikipedia)]  
*[http://cfpub.epa.gov/ncea/cfm/recordisplay.cfm?deid=20563 EPA Exposure factors program interesting for both teaching and opasnet Base]  
*[http://en.wikipedia.org/wiki/Exposure_assessment Exposure assessment (Wikipedia)]  
*[http://en.wikipedia.org/wiki/Exposure_assessment some basic concepts of exposure assessment]  
*[http://en.wikipedia.org/wiki/Biomarkers_of_Exposure_Assessment Biomarkers of exposure assessment (Wikipedia)]  
*[http://en.wikipedia.org/wiki/Biomarkers_of_Exposure_Assessment short description of basic concepts and examples of biomarkers in exposure assessment]  
*[http://en.wikipedia.org/wiki/Mathematical_exposure_modeling Mathematical exposure modeling (Wikipedia)]  
*[http://en.wikipedia.org/wiki/Mathematical_exposure_modeling a short description of exposure modelling with indoor and outdoor air as examples]  
*[http://www.nature.com/jes/journal/v15/n1/pdf/7500411a.pdf Adoption of an official International Society for Exposure Analysis (ISEA)glossary]  
*[http://www.nature.com/jes/journal/v15/n1/pdf/7500411a.pdf official ISEA/IPCS exposure glossary -> put to opasnet glossary]  
*[http://pubs.acs.org/doi/abs/10.1021/es00077a001 Assessing total human exposure to contaminants, Paul Lioy, 1990 (Article)]
*[http://pubs.acs.org/doi/abs/10.1021/es00077a001 total exposure assessment by Paul Lioy (1990)]  
*[http://cfpub.epa.gov/ncea/cfm/recordisplay.cfm?deid=20563 Exposure Factors Program (EPA)]  
*[http://www.epa.gov/ncea/efh/pdfs/efh-chapter02.pdf EPA exposure factors handbook: chapter on uncertainty and variability]
*[http://www.epa.gov/ncea/efh/pdfs/efh-chapter02.pdf Exposure factors handbook (EPA): chapter on uncertainty and variability]


'''Toxicology'''  
'''Toxicology'''  


*[http://en.wikipedia.org/wiki/Toxicity general terms and concepts of toxicology]  
*[http://en.wikipedia.org/wiki/Toxicity Toxicity (Wikipedia)]  
*[http://en.wikipedia.org/wiki/Toxicology a stub with useful links about toxicology]  
*[http://en.wikipedia.org/wiki/Toxicology Toxicology (Wikipedia)]  
*[http://en.wikipedia.org/wiki/No_effect_concentration measures of toxic pollutant concentrations: short description about NOEC and ECx]  
*[http://en.wikipedia.org/wiki/No_effect_concentration Measures of pollutant concentration (Wikipedia)]  
*[http://en.wikipedia.org/wiki/Probit_model mathematics of probit model; advanced material]  
*[http://en.wikipedia.org/wiki/Probit_model Probit model (Wikipedia)]  
*[http://potency.berkeley.edu/ the carcinogenic potency database: learn more about this!]
*[http://potency.berkeley.edu/ The Carcinogenic Potency Database (CPDB) (University of California, Berkley))]


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Revision as of 10:06, 23 February 2011

Decision analysis and risk management (DARM) is a course taught in the | University of Eastern Finland (UEF) for Master's (MSc) Degree Programme in General Toxicology and Environmental Health Risk Assessment ToxEn.

Aims of the course

  • To give a good overview of modern assessment methods,
  • To utilizes modern web workspaces for learning.
  • To avoid overlapping with other courses in the MSc program,

In the course:

The student will learn about the fundamentals of decision analysis; and the connections between societal decision-making and risk assessment. He is able to apply the scientific method and falsification in the context of risk assessment. He also knows how to build an assessment based on the requirements of risk management.     

Course details

  • Name: Decision analysis and risk management          
  • Abbreviation: DARM
  • ECTS-credits: 6
  • Home page of the course: http://en.opasnet.org/w/Darm
  • Degree Programme: ToxEn, Environment health risk assessment
  • Teaching Language: English, with Finnish accent
  • Offered for Students in Other Universities (JOO-opintoja): Yes

Contacts

  • Organising Departments: Department of environmental science (in collaboration with the National Institute for Health and Welfare, THL)          
  • Course Director: Jukka Juutilainen     
  • Teachers: Jouni Tuomisto, Mikko Pohjola, Marko Tainio     
  • Contact Persons email: mikko.pohjola(at)thl.fi     
  • Registration for the Course: Wossikka     

Teaching / Learning Methods

  • Lectures 36 h
  • Group Work 30 h
  • Independent Assessment Study 96 h
  • Web-Based Learning 30 %

Lectures

Schedule and contents of lectures is presented in below Content and schedule table. One lecture is approximately three hours. Theory lectures and exercises column show the main topics of the lectures and links to the lecturing material (e.g. PowerPoint files).

Material column contains additional information from lecturing topics (e.g. articles or book chapters to which the lecture was based on).

Some of the material is in password protected HEANDE page (e.g. due to copy-right reasons). Passwords to HEANDE will be distributed during the lectures.

In the end of this page we have collected large amount of links for further information sources.

Independent Assessment Study

Details will be published soon.

Note! Self-organised group work requires on-line computers.

Evaluation

Scale: 0 (Fail) – 5 (Excellent)

Evaluation is based on:

  • Independent assessment study (2/3)
  • participation in calculation exercises (1/3)
  • Participation in lectures and in discussions will be taken into account while deciding final remarks.


Content and schedule

Schedule and contents of the course.
  • Each row is a three-hour block of lectures, exercises, discussions, or organised group work, in total 69 hours of teaching. In addition, self-organised group work and individual learning is expected to take ca. 100 hours.
  • Changes are likely especially in the content, but the dates presented here are more or less fixed.
  • Abbreviations: RA = risk assessment, DA = decision analysis, RM = risk management, RC = risk communication.
Date Time Lecturer Lecture room Theory lectures and exercises Material Case study discussions and exercises
28.2. 10-13 Jouni, Mikko, Marko Practical introduction to course. (Jouni)
  • Objectives, aims, expectations.
  • Content and teaching/study methods.
  • Example from risk assessment & management study?
Introduction to the case study and exercises (Mikko)
  • swine flu vaccination campaign in Finland 2009-2011: effects and side effects?
  • group work: decision analysis study plan
  • individual work: reflections on risk management options and actions
3.3. 9-12 Jouni, Mikko, Marko Introduction to risk management. What is managed, who is responsible, what is included? Traditional paradigm.
  • Look from decision-maker's point of view: needs, communication, and assessment all included.
  • Openness: RA, RM, RC are not totally separate.
  • Performance: Context about what we actually aim to achieve. How do we know if we succeeded?
  • Developing risk management options.
  • Development of risk assessment questions.
  • Science-policy interface. Why it does not exist.
  • Boundaries of RA and RM
3.3. 13-16 Mikko, Jouni, Marko Beginning of the swine flu story: How the swine flu problem emerged (spring 2009) and spread in the world. Swine flu story (summer 2009): Preparedness in Finland and internationally. Vaccination campaigns, counter-campaigns.
  • Should we launch a vaccination campaign?
  • Should I take vaccination? Should I not take vaccination?
4.3. 9-12 Mikko, Jouni, Marko Introduction to using Opasnet
  • reading and browsing
  • modes of contribution
  • user accounts / logging in
  • basic editing
  • commenting and discussing content
  • Task: Build the page for the group work.
4.3. 13-16 Jouni, Mikko, Marko Decision analysis: introduction
  • Purpose of assessment: Why it is done
  • Concepts: decisions, objectives, optimization, uncertainty, decision trees
  • Measures of outcome: Utility, DALY, QALY, WTP

Probability theory

  • Subjective probability
  • Practical exercise
  • Bayesian rule and Bayesian networks
  • Importance of exhaustiveness (coverage)
*Dennis Lindley: Philosophy of statistics Exercise part one begins: make a decision analysis study plan to find out good policies in this case. Which models to use, what to assess?
8.3. 9-12 Jouni Decision analysis (continued). Swine flu case as a decision problem: what are the relevant decisions, outcomes and questions in the case?
9.3. 9-12 Jouni Decision analysis (continued).
10.3. 9-12 Marko Modeling and Monte Carlo simulation
  • What is modeling or model?
  • Why would you like to use Monte Carlo?
  • Background of the MC method
  • Monte Carlo, simulation and Monte Carlo simulation
  • Practical implementation of MC
    • Programs
    • Defining the probability functions
    • Reading the results
  • Monte Carlo vs. Bayes and Bootstrapping
Swine flu story (autumn - winter 2009): First deaths of swine flu (threat was real). Problems with implementation: long queues in health centers. Clear-cut case falls apart. False alarm? Disease was milder than thought.
11.3. 8-11 Marko Calculation exercise.
  • Case: Mortality due to PM in Kuopio:
    • Exposure-response function
    • Exposure concentration
    • Background mortality
16.3. 9-12 Jouni Bayesian updating
17.3. 9-12 Jouni Calculation exercise of Bayes
18.3. 13-16 Jouni Overall view of different models: Producing result from rationale.
  • Overall view of models.odp
  • Deterministic, heuristic, and probabilistic estimates.
  • Functional, differential, logical, and probabilistic relations.
  • Other relations (neural networks).
First drafts of DA study plans. Brief presentations by students of and discussions about DA study plan drafts.
21.3. 9-12 Jouni, Marko, Mikko Decision making under uncertainty
  • Evaluating an assessment.odp
  • Uncertainty and it's impact (1h Jouni)
  • Sensitivity analysis (1h Marko)
  • Value of information (1h Marko)
  • Acceptability
  • Analysis of model inputs, outputs, and structure
Swine flu story: Use of adjuvants. How similar is the same? Can/Should be aim at zero risk? Benefit-risk comparisons.
22.3. 9-12 Jouni, Mikko, Marko Decision-making under uncertainty (continued). Value of information, Value of information analysis.
  • Assessment performance? Quality of evidence? Impacts of uncertainty in decision-making. Hindsight. (Mikko)
25.3. 9-12 Marko VOI calculation exercise.
  • Case 1: Weather example:
    • Two cities, daily temperature data for 1 year
    • Question: what is the VOI to know the daily temperature vs. average temperature
    • Calculations done in excel
  • Case 2: Risk model:
    • calculation of VOI by hand
    • calculation of expected value of perfect X information using Jouni's VOI function
29.3. 9-12 Jouni, Mikko Full drafts of DA study plans. Presentations by students of and discussions about study plans. Apply the model to assess the case based on your own research plan. Defend your plan in plenary.
  • Are plans executable? What outputs are expected? Do they serve the intended needs?
  • What should the model do? How should the results be used?
  • The core of a model can go through technical check: does it work?
  • The assessment should link to the outside world: does it produce useful info, is it convincing to users?
30.3. 9-12 Mikko, Jouni Risk management (theory). What is managed, who is responsible, what is included? Traditional paradigm.
  • Look from decision-maker's point of view: needs, communication, and assessment all included.
  • What is the role of decision analysis and modeling in RM?
  • Openness: RA, RM, RC are not totally separate.
  • Performance: Context about what we actually aim to achieve. How do we know if we succeeded?
  • Developing risk management options.
  • Development of risk assessment questions.
  • Science-policy interface. Why it does not exist.

Opasnet and other web-based decision support systems.

Exercise part two begins: Risk management actions and options.

31.3. 9-12 Jouni, Mikko Trialogue, collective learning Swine flu story: Secret connections to drug industry? Narcolepsy.
1.4. 9-12 Jouni, Mikko Inference rules. Scientific method as open discussion. Falsification.
  • Do we need pre-peer-review?
7.4. 13-16 Mikko

Discussion: Lectures of concepts

Structuring of discussions in practice and theory

  • Ready-made texts: discussions and organisation
  • Homework: evaluate relevance - validity of arguments. Discuss in groups the next day.
  • Build a structured discussion out of this in groups.
  • Possibly utilise group writing tools?
Swine flu story (autumn 2010): Vaccination campaign halted. THL remains silent about possible risks. Narcolepsy analysis. Impacts of openness. How methods learned should be applied now? Why openness is needed?
8.4. 9-12 Mikko Swine flu story (January 2011): Publishing of narcolepsy results and apologies. Searching for the guilty.
11.4. 9-12 Jouni, Mikko Final seminar: Presentations (exercise parts one and two), discussions, and summary of perspectives to the case.
12.4. 8-11 Jouni, Mikko Wrap-up and course feedback. Final seminar (cont'd).

For the case study description, see D↷.


Keywords

  • Risk assessment
  • Decision analysis
  • Bayesian theory
  • Open assessment
  • Risk management
  • Societal decision making.     

Related courses

Following courses, taught in the University of Eastern Finland (UEF), may have supporting, similar, or overlapping content.


Background information from other Decision analysis and risk management study programs in Europe and in USA is provided here: Decision analysis and risk management - background information

Related further education courses in Kuopio (in Finnish)

Täydennyskoulutuskursseja DARM-kurssin aiheista järjestetään osana ERACedu-riskinarviointikoulutusta. Koulutus järjestetään yksipäiväisinä koulutuksina Kuopiossa. Koulutuksessa voi osallistua yhteen tai useampaan päivään; muiden osien käyminen ei ole välttämätöntä, mutta samassa kuussa järjestettävät koulutukset ovat aihepiiriltään lähellä toisiaan.

  1. Päätösanalyysia ja riskinhallintaa tapausesimerkin kautta ("Mini-DARM") (5.5.2011)
    • Sikainfluenssatapauksen pohjalta toteutettu johdanto päätösanalyysiin ja riskinhallinnan perusteisiin.
  2. Päätöksenteko epävarmuuden oloissa (19.5.2011)
    • Päätösanalyysi ja -mallitus
  3. Keskustelu ja kansalaiskuuleminen päätöksenteossa: menetelmiä ja työkaluja (8.9.2011)
    • Kuinka järjestetään tehokkaasti kansalaiskuulemisia ja avointa osallistumista päätöksentekoon tai vaikutusarviointeihin?
  4. Yhteisöllinen oppiminen (29.9.2011)
    • Osallistava arviointi ja mallitus.

Information from Swine flu


Further information


Courses, course materials, articles, Wikipedia pages and other information sources on different topics related to risk assessment, decision analysis, and risk management.

Statistics

Exposure

Toxicology

Epidemiology and public health

Risk characterisation

Risk management

Risk and impact assessment

Decision analysis and economy

Open assessment

Miscellaneous

Related files

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