IRIS/Oral RfDs

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Question

What are the Oral RfDs according to the IRIS database?

Answer

IRIS/Oral RfDs: Difference between revisions(mg /kg /day)

Obs	Substance	CASNR	Critical Effect	Unit	Oral RfD	Type of RfD	Point of Departure	Overall Confidence	IRIS identifier
1	Acenaphthene	83-32-9	Hepatotoxicity	mg /kg-day	6 x10-2	NOAEL	175	Low	0442
2	Acenaphthylene	208-96-8	Not Assessed under the IRIS program						0443
3	Acephate	30560-19-1	Inhibition of brain ChE	mg /kg-day	4 x10-3	LEL	0.12	High	0354
4	Acetaldehyde	75-07-0	Not Assessed under the IRIS program						0290
5	Acetochlor	34256-82-1	Salivation, increased ALT and ornithine carbamyl transferase; significant increases in triglyceride and decreased blood glucose levels; histopathological changes in kidneys and testes of males	mg /kg-day	2 x10-2	NOAEL	2 mg/kg-day	High	0521
6	Acetone	67-64-1	Nephropathy	mg /kg-day	0.9	NOAEL	900	Medium	0128
7	Acetonitrile	75-05-8	Information reviewed but value not estimated. Refer to IRIS Summary.						0205
8	Acetophenone	98-86-2	General toxicity	mg /kg-day	1 x10-1	NOAEL	423	Low	0321
9	Acetyl chloride	75-36-5	Not Assessed under the IRIS program						0518
10	Acifluorfen, sodium	62476-59-9	Mortality and kidney lesions	mg /kg-day	1.3 x10-2	NOEL	1.25	Medium	0192
11	Acrolein	107-02-8	Decreased survival	mg /kg-day	5 x10-4	NOAEL	0.05	Medium/High	0364
12	Acrylamide	79-06-1	Degenerative nerve changes	mg /kg-day	0.002	HED (BMDL)	0.053	Medium/High	0286
13	Acrylic acid	79-10-7	Reduced pup weight	mg /kg-day	5 x10-1	NOAEL	53	High	0002
14	Acrylonitrile	107-13-1	Not Assessed under the IRIS program						0206
15	Adiponitrile	111-69-3	Not Assessed under the IRIS program						0515
16	Alachlor	15972-60-8	Hemosiderosis, hemolytic anemia	mg /kg-day	1 x10-2	NOAEL	1	High	0129
17	Alar	1596-84-5	No adverse effects	mg /kg-day	1.5 x10-1	NOEL	15	Low	0287
18	Aldicarb	116-06-3	Sweating as clinical sign of AChe inhibition (other effect: Clinical signs and symptoms of acetylcholinesterase inhibition including sweating, pinpoint pupils, leg weakness, and other effects Nausea, diarrhea, and other signs and symptoms)	mg /kg-day	1 x10-3	NOAEL	0.01	Medium	0003
19	Aldicarb sulfone	1646-88-4	Brain ChE inhibition in females	mg /kg-day	1 x10-3	NOAEL	0.11	Medium	0312
20	Aldrin	309-00-2	Liver toxicity	mg /kg-day	3 x10-5	LOAEL	0.025	Medium	0130
21	Ally	74223-64-6	Decreased body weight	mg /kg-day	2.5 x10-1	NOEL	25	High	0288
22	Allyl alcohol	107-18-6	Impaired renal function and increased liver and kidney weights	mg /kg-day	5 x10-3	NOEL	4.8	Low	0004
23	Allyl chloride	107-05-1	Not Assessed under the IRIS program						0387
24	Aluminum phosphide	20859-73-8	Body weight and clinical parameters	mg /kg-day	4 x10-4	NOAEL	0.043	Medium	0005
25	Amdro	67485-29-4	Increased organ weights	mg /kg-day	3 x10-4	NOEL	0.33	High	0207
26	Ametryn	834-12-8	Liver toxicity	mg /kg-day	9 x10-3	NOEL	8.6	Low	0208
27	4-Aminopyridine	504-24-5	Not Assessed under the IRIS program						0440
28	Amitraz	33089-61-1	Increased mean blood sugar concentration; slight hypothermia	mg /kg-day	2.5 x10-3	NOEL	0.25	Medium	0334
29	Ammonia	7664-41-7	Not Assessed under the IRIS program						0422
30	Ammonium acetate	631-61-8	Not Assessed under the IRIS program						0517
31	Ammonium methacrylate	16325-47-6	Not Assessed under the IRIS program						0516
32	Ammonium sulfamate	7773-06-0	Decrease in body weight	mg /kg-day	2 x10-1	NOEL	214.3	Low	0007
33	Aniline	62-53-3	Not Assessed under the IRIS program						0350
34	ortho-Anisidine	90-04-0	Not Assessed under the IRIS program						0610
35	Anthracene	120-12-7	No observed effects	mg /kg-day	3 x10-1	NOEL	1000	Low	0434
36	Antimony	7440-36-0	Longevity, blood glucose, and cholesterol	mg /kg-day	4 x10-4	LOAEL	0.35	Low	0006
37	Antimony trioxide	1309-64-4	Not Assessed under the IRIS program						0676
38	Apollo	74115-24-5	Liver effects; organ weight changes	mg /kg-day	1.3 x10-2	NOEL	1.25	High	0008
39	Aramite	140-57-8	Not Assessed under the IRIS program						0473
40	Aroclor 1016	12674-11-2	Reduced birth weights	mg /kg-day	7 x10-5	NOAEL	0.007	Medium	0462
41	Aroclor 1248	12672-29-6	Information reviewed but value not estimated. Refer to IRIS Summary.						0649
42	Aroclor 1254	11097-69-1	Ocular exudate, inflamed and prominent Meibomian glands, distorted growth of finger and toe nails; decreased antibody (IgG and IgM) response to sheep erythrocytes	mg /kg-day	2 x10-5	LOAEL	0.005	Medium	0389
43	Arsenic, inorganic	7440-38-2	Hyperpigmentation, keratosis and possible vascular complications	mg /kg-day	3 x10-4	NOAEL	0.0008	Medium	0278
44	Arsine	7784-42-1	Not Assessed under the IRIS program						0672
45	Asbestos	1332-21-4	Not Assessed under the IRIS program						0371
46	Assure	76578-14-8	Liver cell enlargement	mg /kg-day	9 x10-3	NOEL	0.9	High	0335
47	Asulam	3337-71-1	Lower ovarian weight, lower liver/body weight	mg /kg-day	5 x10-2	LEL	50	Medium	0284
48	Atrazine	1912-24-9	Decreased body weight gain (other effect: Cardiac toxicity and moderate-to-severe dilation of the right atrium)	mg /kg-day	3.5 x10-2	NOAEL	3.5	High	0209
49	Avermectin B1	65195-55-3	Increased retinal folds in weanlings, decreased viability and lactation indices, decreased pup body weight, increase of dead pups at birth	mg /kg-day	4 x10-4	NOEL	0.12	High	0381
50	Azobenzene	103-33-3	Not Assessed under the IRIS program						0351
51	Barium and Compounds	7440-39-3	Nephropathy	mg /kg-day	0.2	BMDL05	63	Medium	0010
52	Barium cyanide	542-62-1	Information reviewed but value not estimated. Refer to IRIS Summary.						0009
53	Baygon	114-26-1	Mild cholinergic symptoms and RBD ChE inhibition	mg /kg-day	4 x10-3	LEL	0.36	Medium	0210
54	Bayleton	43121-43-3	Decreased body weight gain, erythrocyte count and hemoglobin level	mg /kg-day	3 x10-2	NOEL	2.5	High	0131
55	Baythroid	68359-37-5	Decreased body weights in males, inflammatory foci in kidneys of females	mg /kg-day	2.5 x10-2	NOEL	2.5	High	0132
56	Benefin	1861-40-1	Depressed erythrocyte counts	mg /kg-day	3 x10-1	NOAEL	25	Medium	0133
57	Benomyl	17804-35-2	Decreased pup weanling weights	mg /kg-day	5 x10-2	NOEL	5 mg/kg-day	High	0011
58	Bentazon (Basagran)	25057-89-0	Blood loss into the gastrointestinal tract; coagulation defect in male and female dogs (other effect: Dose-related increase in red areas (presumed blood) in feces; coagulation defect)	mg /kg-day	3.0 x10-2	NOAEL (ADJ)	3.2	Medium	0134
59	Benz[a]anthracene	56-55-3	Not Assessed under the IRIS program						0454
60	Benzaldehyde	100-52-7	Forestomach lesions, kidney toxicity	mg /kg-day	1 x10-1	NOEL	143	Low	0332
61	Benzene	71-43-2	Decreased lymphocyte count	mg /kg-day	4.0 x10-3	BMDL	1.2	Medium	0276
62	Benzidine	92-87-5	Brain cell vacuolization; liver cell alterations in females	mg /kg-day	3 x10-3	LOAEL	2.7	Medium	0135

Rationale

• IRIS

See also

• IRIS

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