View source for Intake of PCDD/F from fish in Beneris

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[[Category:Beneris]]
[[Category:Fish]]
[[Category:Exposures]]
[[Category:Dioxins]]

== '''Scope'''  ==

<br> '''Intake of PCDD/Fs from fish''' describes the exposure to polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) due to fish consumption in the [[Benefit-risk assessment of fish consumption for Beneris#Beneris population|Beneris population]]. 
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== Definition  ==

Intake of PCDD/F from fish in Beneris is represented as a continuous variable and is indexed by variable age. It applies to the whole Beneris population (all age groups 0-2yr, 2-18yr, 18-55yr and 55yr+) and to indicators such as remaining lifetime risk of cancer in adults and risk of developmental dental defects.<br> 

=== Causality  ===

List of parents: 

*[[Concentrations of PCDD/Fs in fish|Concentrations of PCDD/Fs in fish]] 
*[[Domestic fish consumption of the general population in Finland|Domestic fish consumption of the general population in Finland]] 
*[[Body weight in Finland|Body weight in Finland]]

=== Data ===

'''Lifetime cancer risk''' associated with PCDD/Fs is usually estimated using cancer slope factor (CSF) and the lifetime average daily dose (LADD). Therefore, in this case the intake of PCDD/Fs from fish is expressed as LADD. LADD is calculated as a product of average daily dose (ADD) and the ratio of exposure duration and averaging time (=life expectancy at birth), where ADD is the product of average WHO-TEQ concentration of PCDD/Fs in fish and fish intake rate (daily intake of fish) divided by the body weight.

It is assumed that the exposure duration for people from a given age group is the number of years this age group covers. In other words it is assumed that people from a given age group are exposed to PCDD/Fs from the time of entry to this age group until the time of exit from this age group. Therefore, the exposure duration for age group 18-55yr is 37 years and it's 45 years for age group 55yr+ (assuming max age of 100 years). <br> 

Moreover, according to the WHO statistics <ref> World Health Statistics 2008, http://www.terkko.helsinki.fi/english/who/terkkomaterials.htm </ref> the life expectancy at birth in 2006 was 83 and 76 years for Finnish women and men, respectively, and the combined life expectancy was 79 years. 


To evaluate '''non-cancer risks''' the average daily dose (ADD) of PCDD/Fs is used. For children, the ADD of PCDD/Fs from fish is estimated as a product of daily fish consumption and 
the average WHO-TEQ concentration of PCDD/Fs in fish divided by the body weight. 

=== Formula  ===

General formulas (omitting unit conversions): <br>
ADD_species(i)=Average_WHO-TEQ_PCDD/Fs_concentration_species(i)*Daily_consumption_species(i)/BW <br>
LADD_species(i)=Average_WHO-TEQ_PCDD/Fs_concentration_species(i)*Daily_consumption_species(i)*Exposure_duration/(BW*Life_expectancy_at_birth) 

=== Unit  ===

'''ADD''': pg WHO-TEQ/kg bw-day <br>
'''LADD''': mg/kg bw-day

== See also  ==

[http://www.norden.org/pub/sk/showpub.asp?pubnr=2008:531&lang=1 TemaNord report on PCDD/F and PCB in Nordic countries] 

== Result  ==