Dynamic simulation periods are specified in Time's definition. This is usually a list of numbers or labels, typically in some unit of time (days, weeks, months, etc.). Use the ÒDynamic()Ó function in your variables to perform dynamic simulation. 0 0 1 1 2 0 -1460 Focus+scope Moderator References INTARESE WP3.4 PM 14. jouta 2006 16:17 ktluser 10. huhta 2008 16:14 48,24 1,0,-23,1440,799,17 2,102,90,476,224 Arial Narrow, 12 0,Model Intarese_wp3_4,2,2,0,1,C:\Analytica models\Nitrate.ANA Risk model Päivi 11. tamta 2008 10:45 48,24 176,48,1 48,24 1,0,-23,1440,799,17 Population age structure [1] 512,48,1 48,24 Country ['Finland','UK','Spain','Hungary','Romania'] 504,112,1 48,24 2,102,90,476,224 ['Finland','UK','Spain','Hungary','Romania'] Exposure model ktluser 28. maata 2008 10:20 48,24 232,64,1 48,24 1,0,-23,1440,534,17 Source of drinking water % Percentage of population using tap and well water Table(Country,Water_source)( 0.06,0.94, 0,0, 0,0, 0,0, 0,0 ) 160,48,1 48,29 2,0,-23,1440,799 2,0,-23,1072,555,0,MIDM [Water_source,Country] [Undefined,Undefined] [Variable Total_daily_consump1, Variable Total_daily_consump3] Proportion of boiled drinking water 0 1024,120,1 40,32 Total daily consumption of drinking water from public supply by infants < 6 months l/day Truncate( Normal (0.240, 0.247), 0, 0.800 ) 312,152,1 92,28 2,0,-23,1072,555 2,0,-23,1072,555,1,STAT [Constant Source_of_drinking_w, Variable Infants__6_months] [Variable Total_ingestion_of_1] http://rais.ornl.gov/homepage/DRAFT_EXPOSURE_HANDBOOK.pdf Total daily consumption of privately supplied drinking water by infacts < 6 months l/d ({Population_size}*Source_of_drinking_w*Daily_consumption_o1) 104,152,1 60,36 2,0,752,1072,555 [Constant Source_of_drinking_w, Variable Infants__6_months, Chance A4] [Variable Total_ingestion_of_1] Total ingestion of nitrates in drinking water by infacts < 6 months Table(Country,Water_source) 200,272,1 52,36 2,0,-23,1440,799 2,0,-23,1440,799,0,MIDM [Water_source,Country] [Variable Total_daily_consump1, Variable Total_daily_consump3] [Objective Total_met_hb_mortal1] Risk level for NO3- mg/l The risk limit for symptomatic methemoglobinemia due to nitrate in drinking water 100 1024,192,1 48,24 2,0,-23,1431,789 Infants <6 months Number of infants < 6 months in each country Table(Country)( 28.6792K,0,0,0,0) 312,48,1 48,24 2,0,-23,1072,555 2,0,-23,1072,555,0,MIDM [] [Variable Total_daily_consump1, Variable Total_daily_consump3] Population size Table(Country)( 5.194901M,0,0,0,0) 1016,40,1 48,24 2,0,-23,1072,555 Water source ['Tap water','Well water'] 1016,272,1 48,24 ['Tap water','Well water'] Health effects ktluser 28. maata 2008 10:20 48,24 232,184,1 48,24 1,0,-23,1440,799,17 Attributable burden of disease to nitrates in drinking water {Daly_valuation}; {Concentration_of_ni 104,160,1 60,28 [Variable Background_prevalen1, Objective Total_met_hb_mortal1] [Objective Dalys_and_or_financ1] Background prevalence of Met-Hb [1,Infection_status_of_] 288,160,1 64,20 2,0,-23,1152,763 [Objective Attributable_burden1] DALYs and/or financial costs {Dbp_dalys}; {Mirobes_dalys} (Risk_estimate) 104,264,1 48,28 [Objective Attributable_burden1, Variable Daly_and_or_cost_we1] [Objective Risk_estimate] DALY and/or cost weightings 0 288,264,1 48,32 [Objective Dalys_and_or_financ1] Total met-Hb mortality and morbidity due to nitrates in drinking water {Daly_valuation}; {Dbp_health_effects} 104,56,1 64,32 [Variable Total_ingestion_of_1, Variable Exposure_response_f2] [Objective Attributable_burden1] Infection status of infants < 6 months 432,160,1 48,24 NOEL for NO3- mg/l No effect level (NOEL) for nitrate in drinking water 50 712,56,1 48,24 [Objective Health_risk_estimate] Health risk estimate based on recommendations 712,136,1 48,29 [Variable Noel_for_no3_] Risk estimate 0 104,352,1 48,24 Risk_estimate Risk estimate 2 656,24,-1 48,24 Risk estimate 1 64,24,-1 48,24 Dose response model ktluser 28. maata 2008 10:20 48,24 384,64,1 48,24 1,0,-23,1431,789,17 Exposure-response function for nitrate and iMetHg {Dose_response_of_mi; Water_treatment_meth 112,48,1 64,29 [Objective Total_met_hb_mortal1] Sources ktluser 28. maata 2008 10:20 48,24 72,64,1 48,24 1,0,-23,1431,789,17 [NO3] in drinking water from well 0 312,328,1 60,40 [Variable A, Variable Removal_of_nitrate_b, Variable Local_data_on_] [Variable Total_daily_consump3] [NO3] in drinking water from tap [1,Raw_water_quality1,A1,A,Removal_of_nitrate_b, Local_data] 56,328,1 60,40 2,0,-23,1432,789 [Variable A1, Variable A, Variable Removal_of_nitrate_b, Variable Local_data_on_] [NO3] in surface water Lognormal( 1 ) 56,184,1 48,32 2,166,180,476,224 [Constant Usage_of_nitrate_fe1] [Chance A2] [NO3] in ground water [1,Usage_of_nitrate_fe1] 176,184,1 60,36 [Chance A4, Chance A2] Drinking water legistation and guidance levels on nitrates mg NO3-/l Nitrate concentration in drinking water. EU Directive 80/778/ETY for waterworks >5000 people of production >1000m3/d 50 472,104,1 68,32 [Variable Standard_for_nitrat2] Removal of nitrate by treatment {Dbp_exposure_via_dr; Dbp_exposure_via_oth; Dose_response_of_dbp 312,192,1 60,40 [Variable Standard_for_nitrat2, Constant Water_treatment_met1] [Chance A4, Chance A2] Standard for nitrate mg NO3-/l Table(Country)( 50,0,0,0,0) 472,192,1 48,24 2,0,-23,1432,789 [Variable Drinking_water_legi1] [Variable Removal_of_nitrate_b] Usage of nitrate fertilisers in catcment 56,88,1 48,29 [Variable A1] Water treatment method none water treatment methods [1] 312,104,1 48,28 2,0,0,1025,668 [Variable Removal_of_nitrate_b] Does water treatment affect on the concentration??? 296,56,-1 76,20 Local data on [NO3-] in tap and well water Table(Country,Finland_areas_nuts2)( 'Normal (3.6875, 1.021804688)’','’’Normal (1.3125, 0.961304917)','’Normal (2.0625, 2.321291205)','’Normal (3.6875, 2.890100097)', 0,0,0,0, 0,0,0,0, 0,0,0,0, 0,0,0,0 ) 184,328,1 48,29 2,0,-23,1431,789 2,0,-23,1431,789,0,MIDM 2,0,-23,1432,789,1,MIDM [Country,Finland_areas_nuts2] [Finland_areas_nuts2,Country] [Chance A4, Chance A2] Agricultural releases 56,56,-1 52,20 Upstream variables that are not needed since there is data available for the [NO3-] in tap/well water 128,16,-1 128,20 1 192,120,-3 192,128 1,1,1,0,1,1,0,,0, 65535,65535,65535 De1 1 472,120,-3 76,128 1,1,1,0,1,1,0,,0, 65535,65535,65535 De1 1 192,320,-3 196,68 1,1,1,0,1,1,0,,0, 58981,65535,52427 Data needed 56,280,-1 48,24 Needed for risk evaluation? 456,32,-1 48,24 Finland areas NUTS2 ['  FI18','  FI19','  FI13','  FI1A'] 496,176,1 48,24 2,0,-119,1432,790 ['  FI18','  FI19','  FI13','  FI1A'] Risk estimate 232,264,1 48,24 [Alias Risk_estimate1] [Objective Dalys_and_or_financ1] Conceptual model ktluser 10. huhta 2008 12:14 48,24 56,48,1 48,24 1,0,-23,1431,789,17 Attributable burden of disease to nitrates in drinking water {Daly_valuation}; {Concentration_of_ni 976,256,1 60,28 [Variable Background_prevalen2, Objective Total_met_hb_mortal3] [Objective Dalys_and_or_financ2] Background prevalence of Met-Hb [1] 976,320,1 64,20 2,0,-23,1152,763 [Objective Attributable_burden2] Concentration of nitrates in drinking water from private supply 0 376,264,1 60,32 [Variable Concentration_of_ni7, Variable Removal_of_nitrates1] [Variable Total_daily_consump7] Concentration of nitrates in drinking water from public supply [1,Raw_water_quality1,Concentration_of_ni6,Concentration_of_ni7,Removal_of_nitrates1] 536,104,1 72,28 [Variable Total_daily_consump6] Concentration of nitrates in surface water Lognormal( 1 ) 224,104,1 48,32 2,166,180,476,224 [Constant Usage_of_nitrate_fe3] Concentration of nitrates in ground water [1,Usage_of_nitrate_fe3] 224,264,1 48,32 [Variable Concentration_of_ni4] Conceptual model ktluser 10. huhta 2008 12:14 320,600,1 48,24 Daily consumption of bottled water by infacts <6 months [1,Daily_sales_of_bott2] 776,176,1 48,32 [Variable Total_daily_consump6, Variable Total_daily_consump7] Daily sales of bottled water 880,432,1 48,28 DALYs and/or financial costs {Dbp_dalys}; {Mirobes_dalys} 1104,256,1 48,28 [Objective Attributable_burden2, Variable Daly_and_or_cost_we2] DALY and/or cost weightings 0 1104,104,1 48,32 [Objective Dalys_and_or_financ2] Drinking water legistation and guidance levels on nitrates 5 88,264,1 68,32 Exposure-response function {Chlorination}; {Dose_response_of_mi; Water_treatment_meth 984,104,1 64,28 [Objective Total_met_hb_mortal3] Population using private water supplies 728,432,1 48,29 [Variable Total_daily_consump7] Population demanding safe, wholesome and clean drinking water supply 0 88,104,1 68,32 Proportion of boiled drinking water 0 672,176,1 40,32 Raw water quality chemical and microbial quality of raw water [1] 376,432,1 52,28 Removal of nitrates by treatment {Dbp_exposure_via_dr; Dbp_exposure_via_oth; Dose_response_of_dbp 536,368,1 72,24 [Variable Standard_for_nitrat3, Constant Water_treatment_met3] [Variable Concentration_of_ni4] Standard for nitrates [1,Drinking_water_legi2] 88,368,1 64,24 2,0,0,1025,668 [Variable Removal_of_nitrates1] Te1 Actions 80,40,-1 48,24 Te1 Sources 224,40,-1 48,24 Te1 Media 360,40,-1 48,24 Te1 Exposure 696,40,-1 48,24 Te1 Impacts 984,40,-1 44,24 Te1 Valuation 1096,40,-1 48,24 Total daily consumption of drinking water from public supply by infants < 6 months 0 720,104,1 92,28 [Variable Concentration_of_ni5, Variable Daily_consumption_o2] Total daily consumption of privately supplied drinking water by infacts < 6 months 1 728,368,1 100,24 2,102,90,476,224 [Variable Concentration_of_ni4, Variable Daily_consumption_o2, Constant Population_using_pr2] Total ingestion of nitrates in drinking water by infacts < 6 months [1,Total_daily_consump6,Total_daily_consump7,Proportion_of_boile2,Population_demandin2] 720,256,1 92,24 2,102,90,476,224 [Objective Total_met_hb_mortal3] Total met-Hb mortality and morbidity due to nitrates in drinking water {Daly_valuation}; {Dbp_health_effects} 976,176,1 64,32 [Variable Exposure_response_f1, Variable Total_ingestion_of_3] [Objective Attributable_burden2] Usage of nitrate fertilisers in catcment 208,432,1 48,29 [Variable Concentration_of_ni6] Water treatment method none water treatment methods [1] 536,432,1 48,28 2,0,0,1025,668 [Variable Removal_of_nitrates1]