ERF of omega-3 fatty acids

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Question

What is the exposure-response function (ERF) of omega-3 fatty acids?

Answer

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ERF of omega-3 fatty acids on intelligence quotient.png

Rationale

Exposure-response of fish oil intake for MI risk in adults is indexed by variable age. It applies to the last two age categories.

Data

ERF

ERF of omega-3 fatty acids(-)
ObsExposure agentTraitResponse metricExposure routeExposure metricExposure unitERF parameterThresholdERFDescription
1DHAChild´s IQChange in IQ pointsPlacentaMaternal intakemg/kg bw/dayERS00.07 +- 0.01Cohen et al. 2005; Gradowska 2013; Standard deviation
2Omega3CHDΔlog(CHD mortality rate)IngestionIntake from fishmg/day EPA+DHARR00.9802 +- 0.000389Mozaffarian and Rimm 2006; Gradowska 2013 SD = exp(-0.02)-exp(-0.02+3.97E-4)
3FishSubclinical brain infarct (one or more)PrevalenceIngestionIntake of tuna/other fish≥3 times/week vs. <1/monthRR00.74 (0.54 - 1.01)Virtanen et al. 2008; 95% CI
4FishAny prevalent subclinical brain infarctPrevalenceIngestionIntake of tuna/other fishEach one serving per weekRR00.93 (0.88 - 0.994)Virtanen et al. 2008; 95% CI
5FishSubclinical brain infarct (one or more)IncidenceIngestionIntake of tuna/other fish≥3 times/week vs. <1/monthRR00.56 (0.30 - 1.07)Virtanen et al. 2008; 95% CI
6FishAny incident subclinical brain infarctIncidenceIngestionIntake of tuna/other fishEach one serving per weekRR00.89 (0.78 - 0.993)Virtanen et al. 2008; 95% CI
7FishStatus of cerebral white matterGrade scoreIngestionIntake of tuna/other fishEach one serving per week1 /grade score00.038Virtanen et al. 2008; 95% CI
8TEQDevelopmental dental defects incl. agenesisYes/No according to "Developmental Defects of Enamel Index" Ingestion etc. (as it was in Seveso)log(TCDD serum concentration+1)ng/kg in fatERS00.26 +- 0.12Alaluusua et al. 2004; PL Gradowska PhD thesis 2013; ERF:n laatu on epäselvä
9TEQCancerLifetime probability of developing cancerIngestionIntakekg bw d /mgOral CSF0156000US EPA
10MeHgChildhood intelligenceIQ changePlacentaMaternal MeHg concentration in hairug /gERS0-0.7 (-1.5 - 0)

ERF publications

ERF data as described in original articles
Exposure agent Trait Response metric Exposure route Exposure metric Exposure unit ERF parameter Threshold ERF Description
DHA Child´s IQ Change in IQ points Placenta Maternal intake mg/kg bw/day ERS 0 0.07(±0.01) Cohen et al. 2005; Gradowska 2013
Omega3 CHD Δlog(CHD mortality rate) Ingestion Intake from fish mg/day EPA+DHA ERS 0 -0.002 (±3.97E-4) Mozaffarian and Rimm 2006; Gradowska 2013
Fish Subclinical brain infarct (one or more) Prevalence Ingestion Intake of tuna/other fish =3 times/week vs. <1/month RR 0 0.74(0.54-1.01) Virtanen et al. 2008
Fish Any prevalent subclinical brain infarct Prevalence Ingestion Intake of tuna/other fish Each one serving per week Decrease in RR % 0 7(0.6-12) Virtanen et al. 2008
Fish Subclinical brain infarct (one or more) Incidence Ingestion Intake of tuna/other fish =3 times/week vs. <1/month RR 0 0.56(0.30-1.07) Virtanen et al. 2008
Fish Any incident subclinical brain infarct Incidence Ingestion Intake of tuna/other fish Each one serving per week Decrease in RR % 0 11(0.7-22) Virtanen et al. 2008
Fish Status of cerebral white matter Grade score Ingestion Intake of tuna/other fish Each one serving per week Increase in grade score % 0 3.8 Virtanen et al. 2008
TEQ Developmental dental defects incl. agenesis Yes/No according to "Developmental Defects of Enamel Index" Ingestion etc. (as it was in Seveso) log(TCDD serum concentration+1) ng/kg in fat ERS 0 0.26 (±0.12) Alaluusua et al. 2004; PL Gradowska PhD thesis 2013
TEQ Cancer Lifetime probability of developing cancer Ingestion Intake (mg/kg bw/d)^-1 Oral CSF 0 156000 US EPA
MeHg Childhood intelligence IQ change Placenta Maternal MeHg concentration in hair ug /g ERS 0 -1.5;-0.7;0

The study by Cohen et al. 2005 [1] estimates that increasing maternal docosahexaenoic acid (DHA) intake by 100 mg/day increases child's IQ by 0.13 points D↷. This value represents central estimate while the upper and lower bound for this ERF is 0.08 and 0.18. Triangular distribution is used.

Study by Cohen et al[1] finds that prenatal MeHg exposure sufficient to increase the concentration of mercury in maternal hair at parturition by 1 µg/g decreases IQ by 0.7 points. The paper identifies important sources of uncertainty influencing this estimate, concluding that the plausible range of values for this loss is 0 to 1.5 IQ points. A triangular distribution with parameters: min = 0, mode = 0.7 and max = 1.5 was created. Distribution by author judgement. See ERF of methyl mercury.

Data also from (some pages should be merged)

Incidences

Incidences(#/py)
ObsTraitResponse metricAgeIncidenceDescription
1CHDIncidenceAdult0.002510000 CHD deaths per 4000000 py in Finland
2Subclinical brain infarct (one or more)IncidenceAdult0.0025guesswork

Unit

IQ points/(100mg omega-3/d)

Calculations

References

  1. Cohen, J.T., PhD, Bellinger, D.C, PhD, W.E., MD, Bennett A., and Shaywitz B.A. 2005b. A Quantitative Analysis of Prenatal Intake of n-3 Polyunsaturated Fatty Acids and Cognitive Development. American Journal of Preventive Medicine 2005;29(4):366–374).