Difference between revisions of "ERF of omega-3 fatty acids"

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DHA|Child´s IQ|Change in IQ points|Placenta|Maternal intake|mg/kg bw/day|ERS|0|0.07 +- 0.01|Cohen et al. 2005; Gradowska 2013
 
DHA|Child´s IQ|Change in IQ points|Placenta|Maternal intake|mg/kg bw/day|ERS|0|0.07 +- 0.01|Cohen et al. 2005; Gradowska 2013
 
Omega3|CHD|Δlog(CHD mortality rate)|Ingestion|Intake from fish|mg/day EPA+DHA|RR|0|0.9802 +- 0.000389|Mozaffarian and Rimm 2006; Gradowska 2013  SD  = exp(-0.02)-exp(-0.02+3.97E-4)
 
Omega3|CHD|Δlog(CHD mortality rate)|Ingestion|Intake from fish|mg/day EPA+DHA|RR|0|0.9802 +- 0.000389|Mozaffarian and Rimm 2006; Gradowska 2013  SD  = exp(-0.02)-exp(-0.02+3.97E-4)
Fish|Subclinical brain infarct (one or more)|Prevalence|Ingestion|Intake of tuna/other fish|≥3 times/week vs. <1/month|RR|0|0.74 (0.54 - 1.01)|Virtanen et al. 2008
+
Fish|Subclinical brain infarct (one or more)|Prevalence|Ingestion|Intake of tuna/other fish|≥3 times/week vs. <1/month|RR|0|0.74 (0.54 - 1.01)|Virtanen et al. 2008; 95% CI
Fish|Any prevalent subclinical brain infarct|Prevalence|Ingestion|Intake of tuna/other fish|Each one serving per week|RR|0|0.93 (0.88 - 0.994)|Virtanen et al. 2008
+
Fish|Any prevalent subclinical brain infarct|Prevalence|Ingestion|Intake of tuna/other fish|Each one serving per week|RR|0|0.93 (0.88 - 0.994)|Virtanen et al. 2008; 95% CI
Fish|Subclinical brain infarct (one or more)|Incidence|Ingestion|Intake of tuna/other fish|≥3 times/week vs. <1/month|RR|0|0.56 (0.30 - 1.07)|Virtanen et al. 2008
+
Fish|Subclinical brain infarct (one or more)|Incidence|Ingestion|Intake of tuna/other fish|≥3 times/week vs. <1/month|RR|0|0.56 (0.30 - 1.07)|Virtanen et al. 2008; 95% CI
Fish|Any incident subclinical brain infarct|Incidence|Ingestion|Intake of tuna/other fish|Each one serving per week|RR|0|0.89 (0.78 - 0.993)|Virtanen et al. 2008  
+
Fish|Any incident subclinical brain infarct|Incidence|Ingestion|Intake of tuna/other fish|Each one serving per week|RR|0|0.89 (0.78 - 0.993)|Virtanen et al. 2008; 95% CI
Fish|Status of cerebral white matter|Grade score|Ingestion|Intake of tuna/other fish|Each one serving per week|1 /grade score|0|0.038|Virtanen et al. 2008
+
Fish|Status of cerebral white matter|Grade score|Ingestion|Intake of tuna/other fish|Each one serving per week|1 /grade score|0|0.038|Virtanen et al. 2008;  95% CI
 
TEQ|Developmental dental defects incl. agenesis|Yes/No according to "Developmental Defects of Enamel Index" |Ingestion etc. (as it was in Seveso)|log(TCDD serum concentration+1)|ng/kg in fat|ERS|0|0.26 +- 0.12|Alaluusua et al. 2004; PL Gradowska PhD thesis 2013
 
TEQ|Developmental dental defects incl. agenesis|Yes/No according to "Developmental Defects of Enamel Index" |Ingestion etc. (as it was in Seveso)|log(TCDD serum concentration+1)|ng/kg in fat|ERS|0|0.26 +- 0.12|Alaluusua et al. 2004; PL Gradowska PhD thesis 2013
 
TEQ|Cancer|Lifetime probability of developing cancer|Ingestion|Intake|kg bw d /mg|Oral CSF|0|156000|US EPA
 
TEQ|Cancer|Lifetime probability of developing cancer|Ingestion|Intake|kg bw d /mg|Oral CSF|0|156000|US EPA

Revision as of 14:59, 28 May 2014



Question

What is the exposure-response function (ERF) of omega-3 fatty acids?

Answer

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ERF of omega-3 fatty acids on intelligence quotient.png

Rationale

Exposure-response of fish oil intake for MI risk in adults is indexed by variable age. It applies to the last two age categories.

Data

ERF

Difference between revisions of "ERF of omega-3 fatty acids"(-)
ObsExposure agentTraitResponse metricExposure routeExposure metricExposure unitERF parameterThresholdERFDescription
1DHAChild´s IQChange in IQ pointsPlacentaMaternal intakemg/kg bw/dayERS00.07 +- 0.01Cohen et al. 2005; Gradowska 2013
2Omega3CHDΔlog(CHD mortality rate)IngestionIntake from fishmg/day EPA+DHARR00.9802 +- 0.000389Mozaffarian and Rimm 2006; Gradowska 2013 SD = exp(-0.02)-exp(-0.02+3.97E-4)
3FishSubclinical brain infarct (one or more)PrevalenceIngestionIntake of tuna/other fish≥3 times/week vs. <1/monthRR00.74 (0.54 - 1.01)Virtanen et al. 2008; 95% CI
4FishAny prevalent subclinical brain infarctPrevalenceIngestionIntake of tuna/other fishEach one serving per weekRR00.93 (0.88 - 0.994)Virtanen et al. 2008; 95% CI
5FishSubclinical brain infarct (one or more)IncidenceIngestionIntake of tuna/other fish≥3 times/week vs. <1/monthRR00.56 (0.30 - 1.07)Virtanen et al. 2008; 95% CI
6FishAny incident subclinical brain infarctIncidenceIngestionIntake of tuna/other fishEach one serving per weekRR00.89 (0.78 - 0.993)Virtanen et al. 2008; 95% CI
7FishStatus of cerebral white matterGrade scoreIngestionIntake of tuna/other fishEach one serving per week1 /grade score00.038Virtanen et al. 2008; 95% CI
8TEQDevelopmental dental defects incl. agenesisYes/No according to "Developmental Defects of Enamel Index" Ingestion etc. (as it was in Seveso)log(TCDD serum concentration+1)ng/kg in fatERS00.26 +- 0.12Alaluusua et al. 2004; PL Gradowska PhD thesis 2013
9TEQCancerLifetime probability of developing cancerIngestionIntakekg bw d /mgOral CSF0156000US EPA
10MeHgChildhood intelligenceIQ changePlacentaMaternal MeHg concentration in hairug /gERS0-0.7 (-1.5 - 0)

ERF publications

ERF data as described in original articles
Exposure agent Trait Response metric Exposure route Exposure metric Exposure unit ERF parameter Threshold ERF Description
DHA Child´s IQ Change in IQ points Placenta Maternal intake mg/kg bw/day ERS 0 0.07(±0.01) Cohen et al. 2005; Gradowska 2013
Omega3 CHD Δlog(CHD mortality rate) Ingestion Intake from fish mg/day EPA+DHA ERS 0 -0.002 (±3.97E-4) Mozaffarian and Rimm 2006; Gradowska 2013
Fish Subclinical brain infarct (one or more) Prevalence Ingestion Intake of tuna/other fish =3 times/week vs. <1/month RR 0 0.74(0.54-1.01) Virtanen et al. 2008
Fish Any prevalent subclinical brain infarct Prevalence Ingestion Intake of tuna/other fish Each one serving per week Decrease in RR % 0 7(0.6-12) Virtanen et al. 2008
Fish Subclinical brain infarct (one or more) Incidence Ingestion Intake of tuna/other fish =3 times/week vs. <1/month RR 0 0.56(0.30-1.07) Virtanen et al. 2008
Fish Any incident subclinical brain infarct Incidence Ingestion Intake of tuna/other fish Each one serving per week Decrease in RR % 0 11(0.7-22) Virtanen et al. 2008
Fish Status of cerebral white matter Grade score Ingestion Intake of tuna/other fish Each one serving per week Increase in grade score % 0 3.8 Virtanen et al. 2008
TEQ Developmental dental defects incl. agenesis Yes/No according to "Developmental Defects of Enamel Index" Ingestion etc. (as it was in Seveso) log(TCDD serum concentration+1) ng/kg in fat ERS 0 0.26 (±0.12) Alaluusua et al. 2004; PL Gradowska PhD thesis 2013
TEQ Cancer Lifetime probability of developing cancer Ingestion Intake (mg/kg bw/d)^-1 Oral CSF 0 156000 US EPA
MeHg Childhood intelligence IQ change Placenta Maternal MeHg concentration in hair ug /g ERS 0 -1.5;-0.7;0

The study by Cohen et al. 2005 [1] estimates that increasing maternal docosahexaenoic acid (DHA) intake by 100 mg/day increases child's IQ by 0.13 points D↷. This value represents central estimate while the upper and lower bound for this ERF is 0.08 and 0.18. Triangular distribution is used.

Study by Cohen et al[1] finds that prenatal MeHg exposure sufficient to increase the concentration of mercury in maternal hair at parturition by 1 µg/g decreases IQ by 0.7 points. The paper identifies important sources of uncertainty influencing this estimate, concluding that the plausible range of values for this loss is 0 to 1.5 IQ points. A triangular distribution with parameters: min = 0, mode = 0.7 and max = 1.5 was created. Distribution by author judgement. See ERF of methyl mercury.

Data also from (some pages should be merged)

Incidences

Incidences(#/py)
ObsTraitResponse metricAgeIncidenceDescription
1CHDIncidenceAdult0.002510000 CHD deaths per 4000000 py in Finland
2Subclinical brain infarct (one or more)IncidenceAdult0.0025guesswork

Unit

IQ points/(100mg omega-3/d)

Calculations

References

  1. Cohen, J.T., PhD, Bellinger, D.C, PhD, W.E., MD, Bennett A., and Shaywitz B.A. 2005b. A Quantitative Analysis of Prenatal Intake of n-3 Polyunsaturated Fatty Acids and Cognitive Development. American Journal of Preventive Medicine 2005;29(4):366–374).