Difference between revisions of "ERF of dioxin"

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Cancer|Lifetime probability of developing cancer|Oral|Dose|(mg/kg bw/d)^-1||Oral CSF|156000|US EPA
 
Cancer|Lifetime probability of developing cancer|Oral|Dose|(mg/kg bw/d)^-1||Oral CSF|156000|US EPA
 
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Revision as of 14:36, 6 February 2014

Question

ERF of dioxin on cancer describes the quantitative relationship between exposure to polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans (PCDD/Fs) and remaining lifetime cancer risk in adult Beneris population.

Answer

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You must define units. Please use syntax: unit="unit"
Difference between revisions of "ERF of dioxin"()
ObsDiseaseResponse metricExposure routeExposure metricExposure unitThresholdERF parameterERFDescription
1CancerLifetime probability of developing cancerOralDose(mg/kg bw/d)^-1Oral CSF156000US EPA

Definition

ERF of dioxin on cancer is indexed by variable age. It applies to the last two age categories, i.e. 18-55yr and 55yr+ (gender combined).

Rationale

Data

The U.S. Environmental Protection Agency (US EPA) calculated an oral cancer slope factor (CSF) for 2,3,7,8 - TCDD (the most toxic dioxin compound). This CFS equals to 156000 (mg/kg bw-d)-1 and represents the upper 95th percentile estimate of the probability of developing cancer per unit intake of chemical over a lifetime. [1]

Formula

Unit

(mg/kg bw/d)-1

References

  1. US EPA 2000. Guidance for assessing chemical contaminant data for use in fish advisories. Volume 1: Fish sampling and analysis, 3rd edition. http://www.epa.gov/waterscience/fish/advice/volume1/