ERF for long-term indoor exposure to radon and lung cancer

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Scope

What is the exposure-response function of indoor air radon on lung cancer. Radon exposure is assumed to occur as a long-term exposure to radon in indoor air.

Definition

Data

Radon is classified by International Agency for the Research on Cancer as known human carcinogen (IARC Group 1). The unit risk estimate for radon is 3-6*10-5 Bq/m3 (Pershagen et al. 1994). [1]

Based on a meta-analysis of European case control studies Darby et al. 2005 [2] and 2006 [3] estimate that for each 100 Bq/m3 increase of radon concentration there is 16 % (95%CI 5%-31%) increase in lung cancer risk.

Dependencies

Unit

RR per 100 Bq/m3

Formula

Result

1.16 (95 % CI 1.05 - 1.31)

See also


References

  1. EnVIE final report. KTL, Kuopio, 2008. [1]
  2. Darby S, Hill D, Auvinen A, Barros-Dios JM, Baysson H, Bochicchio F, Deo H, Falk R, Forastiere F, Hakama M, Heid I, Kreienbrock L, Kreutzer M, Lagarde F, Mäkeläinen I, Muirhead C, Obereigner W, Pershagen G, Ruano-Ravina A, Ruosteenoja E, Schaffrath-Rosario A, Tirmarche M, Tomasek L, Whitley E, Wichmann H-E, Doll R. Radon in homes and lung cancer risk: collaborative analysis of individual data from 13 European case-control studies. British Medical Journal 2005; 330: 223–226.
  3. Darby S, Hill D, Deo H, Auvinen A, Barros-Dios JM, Baysson H, Bochicchio F, Falk R, Farchi S, Figueiras A, Hakama M, Heid I, Hunter N, Kreienbrock L, Kreuzer M, Lagarde FC, Mäkeläinen I, Muirhead C, Oberaigner W, Pershagen G, Ruosteenoja E, Schaffrath Rosario A, Tirmarche M, Tomášek L, Whitley E, Wichmann H-E, Doll R. Residential radon and lung cancer – detailed results of a collaborative analysis of individual data on 7148 persons with lung cancer and 14 208 persons without lung cancer from 13 epidemiologic studies in Europe. Scandinavian Journal of Work, Environment Health 2006; 32 Suppl 1: 1–84.

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