Difference between revisions of "ERF for long-term indoor exposure to radon and lung cancer"

From Opasnet
Jump to: navigation, search
(Created page with '== Scope == Exposure-response function for long-term (chronic) exposure to indoor air radon and risk of lung cancer. == Definition == === Data === '''Darby et al. 2005 <ref>D…')
 
m (Answer)
 
(8 intermediate revisions by the same user not shown)
Line 1: Line 1:
== Scope ==
+
[[Category:Indoor air]]
 +
[[Category:Radon]]
 +
[[Category:Exposure-response functions]]
 +
{{variable|moderator=Teemu R}}
  
Exposure-response function for long-term (chronic) exposure to indoor air radon and risk of lung cancer.
+
==Question==
  
== Definition ==
+
What is the exposure-response function of indoor air radon on lung cancer? Radon exposure is assumed to occur as a long-term exposure to radon in indoor air.
 +
 
 +
==Answer==
 +
 
 +
'''Exposure-response function
 +
 
 +
<t2b index="Response metric,Exposure route,Exposure metric,Exposure unit,Threshold,ERF parameter,Observation" locations="ERF,Description" unit="RR per Bq/m3">
 +
Incidence|Inhalation|Annual average indoor concentration|Bq/m3|0|RR|1.0016 (1.0005 – 1.0031)|Darby 2004
 +
</t2b>
 +
 
 +
Page-specific entries (indices that have exactly one value each for the whole variable; usually mentioned in the title and/or in the scope.):
 +
* Pollutant: Radon
 +
* Disease: Lung cancer
 +
 
 +
==Rationale==
  
 
=== Data ===
 
=== Data ===
  
'''Darby et al. 2005 <ref>Darby S, Hill D, Auvinen A, Barros-Dios JM, Baysson H, Bochicchio F, Deo H, Falk R, Forastiere F, Hakama M, Heid I, Kreienbrock L, Kreutzer M, Lagarde F, Mäkeläinen I, Muirhead C, Obereigner W, Pershagen G, Ruano-Ravina A, Ruosteenoja E, Schaffrath-Rosario A, Tirmarche M, Tomasek L, Whitley E, Wichmann H-E, Doll R. Radon in homes and lung cancer risk: collaborative analysis of individual data from 13 European case-control studies. British Medical Journal 2005; 330: 223–226.</ref>
+
:''A piece of data was moved from [http://heande.opasnet.org/heande/index.php?title=Radon_sis%C3%A4ilma_annos-vaste&oldid=28388 a previous version of radon ERF in Heande].
 +
 
 +
Radon  is  classified  by  International Agency  for  the Research  on Cancer  as  known  human
 +
carcinogen (IARC Group 1). The unit risk estimate for radon is 3-6*10<sup>-5</sup> Bq/m<sup>3</sup> (Pershagen et al. 1994). <ref>EnVIE final report. KTL, Kuopio, 2008. [http://heande.opasnet.org/heande/extensions/mfiles/mf_getfile.php?anon=true&docid=3318&docver=2&fileid=3318&filever=1&filename=EnVIE%20WP2%20Final%20Report.pdf]</ref>
 +
 
 +
IARC: Group 1 (Carcinogenic to humans): Radon-222 [10043-92-2] and its decay products (Vol. 43, Vol. 78; 2001) <ref>IARC: Group 1 (Carcinogenic to humans): Radon-222 [10043-92-2] and its decay products (Vol. 43, Vol. 78; 2001)[http://monographs.iarc.fr/ENG/Classification/crthgr01.php] </ref>
 +
 
 +
United Nations Scientific Committee on the Effects of Atomic Radiation (UNSCEAR): 21 July 2009: There is mounting direct evidence to confirm a small but detectable risk of lung cancer from living with radon in the home <ref>United Nations Scientific Committee on the Effects of Atomic Radiation (UNSCEAR): 21 July 2009: There is mounting direct evidence to confirm a small but detectable risk of lung cancer from living with radon in the home [http://www.unscear.org/docs/Radon-distrib.pdf]</ref>
 +
 
 +
Based on a meta-analysis of European case control studies Darby et al. 2005
 +
<ref>Darby S, Hill D, Auvinen A, Barros-Dios JM, Baysson H, Bochicchio F, Deo H, Falk R, Forastiere F, Hakama M, Heid I, Kreienbrock L, Kreutzer M, Lagarde F, Mäkeläinen I, Muirhead C, Obereigner W, Pershagen G, Ruano-Ravina A, Ruosteenoja E, Schaffrath-Rosario A, Tirmarche M, Tomasek L, Whitley E, Wichmann H-E, Doll R. Radon in homes and lung cancer risk: collaborative analysis of individual data from 13 European case-control studies. British Medical Journal 2005; 330: 223–226.[http://www.bmj.com/cgi/content/full/330/7485/223]</ref>
 +
and 2006
 +
<ref name="darby2006">Darby S, Hill D, Deo H, Auvinen A, Barros-Dios JM, Baysson H, Bochicchio F, Falk R, Farchi S, Figueiras A, Hakama M, Heid I, Hunter N, Kreienbrock L, Kreuzer M, Lagarde FC, Mäkeläinen I, Muirhead C, Oberaigner W, Pershagen G, Ruosteenoja E, Schaffrath Rosario A, Tirmarche M, Tomášek L, Whitley E, Wichmann H-E, Doll R. Residential radon and lung cancer – detailed results of a collaborative analysis of individual data on 7148 persons with lung cancer and 14 208 persons without lung cancer from 13 epidemiologic studies in Europe. Scandinavian Journal of Work, Environment Health 2006; 32 Suppl 1: 1–84. </ref>
 +
estimate that for each 100 Bq/m<sup>3</sup> increase of radon concentration there is 16 % (95%CI 5%-31%) increase in lung cancer risk.
 +
<ref>EnVIE final report. KTL, Kuopio, 2008. [http://heande.opasnet.org/heande/extensions/mfiles/mf_getfile.php?anon=true&docid=3318&docver=2&fileid=3318&filever=1&filename=EnVIE%20WP2%20Final%20Report.pdf]</ref>
 +
 
 +
It is assumed that the relative risk does not change due to age, sex, or smoking.
 +
 
  
16% increase in the risk of lung cancer per 100 Bq/m3 increase in usual radon concentrations
+
'''Finnish situation based on [[:op_fi:Seturi|Seturi]] calculations:
  
=== Causality ===
+
* Lung cance mortality in Finland (2006): (M 1467 + F 544=) 2011 deaths<ref name="darby2006"/>
 +
* Extra lung cancer deaths due to radon in Finland: (mean; min; max): 346; 108; 666
 +
* Indoor radon causes 364 (108-666) lung cancer deaths in Finland annually, which is 17% of all lung cancer deaths.
  
=== Unit ===
 
  
RR per 100 Bq/m3
+
'''Major uncertainties (in Finnish)
  
=== Formula ===
+
Tärkein keuhkosyövän syytekijä on tupakointi. Suhteellisesti radon lisää keuhkosyövän riskiä yhtä paljon tupakoitsijoilla ja tupakoimattomilla.
 +
Kolmenkymmenen vuoden asuminen noin 700 Bq/m3 radonpitoisuudessa kaksinkertaistaa riskin sairastua keuhkosyöpään 75 vuoden ikään mennessä verrattuna siihen, että olisi asunut matalissa radonpitoisuuksissa. Pienessä radonpitoisuudessa (<100 Bq/m3) asuvalla tupakoitsijalla on noin 10% todennäköisyys saada keuhkosyöpä, kun taas tupakoimattomalla riski on noin 0,4%. Tupakoitsijan riski korkeassa radonpitoisuudessa (700 Bq/m3) on kaksinkertainen (2 * 10% eli 20%) ja tupakoimattoman samoin kaksinkertainen (eli 0,8%).
  
Algebra or other explicit methods if possible
+
Tupakoitsijoilla radonista aiheu­tuva riski on siis absoluuttisesti suurempi kuin tupa­koimattomilla.
(e.g. [[Analytica]] code between the <nowiki>''<anacode></anacode>''</nowiki> delimiters).
 
  
== Result ==
+
=== Unit ===
  
1.16
+
RR per Bq/m<sup>3</sup>
  
 
==See also==
 
==See also==
  
Links to relevant information that does not belong to ''Definition''.
+
*[[Radon]]
 +
* [[ERF for long-term indoor exposure to radon and lung cancer]]
 +
* [http://rem.jrc.ec.europa.eu/RemWeb/Publications/EUR_RADON.pdf An Overview of Radon Surveys in Europe]. Joint Research Centre, 2005. ISBN 92-79-01066-2
 +
* In [[Heande]] (password-protected)
 +
*[[:heande:HI:Radon Indoor Air Case]]
 +
** [[:heande:Indoor air quality & its impact on man|Indoor air quality & its impact on man]]
 +
** [[:heande:Radon|Radon]]
 +
** [[:heande:Indoor air|Indoor air]]
 +
** [http://heande.opasnet.org/heande/index.php?title=Radon_sis%C3%A4ilma_annos-vaste&oldid=28388 A previous version of radon ERF in Heande]
 +
** [[:heande:Radon sisäilma altistus Suomi|Radon sisäilma altistus Suomi]]
 +
** [[:heande:Radon ja pitkäikäiset nuklidit porakaivo, kokonaissyöpäkuolemat annos-vaste|Radon ja pitkäikäiset nuklidit porakaivo]]
 +
** [[:heande:Radon ja pitkäikäiset nuklidit porakaivo, efektiivinen annos|Radon ja pitkäikäiset nuklidit porakaivo]]
 +
** [[:heande:Radon ja pitkäikäiset nuklidit porakaivovedessä|Radon ja pitkäikäiset nuklidit porakaivovedessä]]
 +
** http://heande.opasnet.org/heande/images/6/67/SETURI_laskenta03.xls
  
 
==References==
 
==References==
  
Will appear here automatically, if cited above using the ''<nowiki><ref></ref></nowiki>'' tags.
+
<references/>
Additional references can also be listed here.
+
 
 +
==Related files==
  
<references/>
+
{{mfiles}}

Latest revision as of 12:30, 3 January 2012



Question

What is the exposure-response function of indoor air radon on lung cancer? Radon exposure is assumed to occur as a long-term exposure to radon in indoor air.

Answer

Exposure-response function

Difference between revisions of "ERF for long-term indoor exposure to radon and lung cancer"(RR per Bq/m3)
ObsResponse metricExposure routeExposure metricExposure unitThresholdERF parameterERFDescription
1IncidenceInhalationAnnual average indoor concentrationBq/m30RR1.0016 (1.0005 – 1.0031)Darby 2004

Page-specific entries (indices that have exactly one value each for the whole variable; usually mentioned in the title and/or in the scope.):

  • Pollutant: Radon
  • Disease: Lung cancer

Rationale

Data

A piece of data was moved from a previous version of radon ERF in Heande.

Radon is classified by International Agency for the Research on Cancer as known human carcinogen (IARC Group 1). The unit risk estimate for radon is 3-6*10-5 Bq/m3 (Pershagen et al. 1994). [1]

IARC: Group 1 (Carcinogenic to humans): Radon-222 [10043-92-2] and its decay products (Vol. 43, Vol. 78; 2001) [2]

United Nations Scientific Committee on the Effects of Atomic Radiation (UNSCEAR): 21 July 2009: There is mounting direct evidence to confirm a small but detectable risk of lung cancer from living with radon in the home [3]

Based on a meta-analysis of European case control studies Darby et al. 2005 [4] and 2006 [5] estimate that for each 100 Bq/m3 increase of radon concentration there is 16 % (95%CI 5%-31%) increase in lung cancer risk. [6]

It is assumed that the relative risk does not change due to age, sex, or smoking.


Finnish situation based on Seturi calculations:

  • Lung cance mortality in Finland (2006): (M 1467 + F 544=) 2011 deaths[5]
  • Extra lung cancer deaths due to radon in Finland: (mean; min; max): 346; 108; 666
  • Indoor radon causes 364 (108-666) lung cancer deaths in Finland annually, which is 17% of all lung cancer deaths.


Major uncertainties (in Finnish)

Tärkein keuhkosyövän syytekijä on tupakointi. Suhteellisesti radon lisää keuhkosyövän riskiä yhtä paljon tupakoitsijoilla ja tupakoimattomilla. Kolmenkymmenen vuoden asuminen noin 700 Bq/m3 radonpitoisuudessa kaksinkertaistaa riskin sairastua keuhkosyöpään 75 vuoden ikään mennessä verrattuna siihen, että olisi asunut matalissa radonpitoisuuksissa. Pienessä radonpitoisuudessa (<100 Bq/m3) asuvalla tupakoitsijalla on noin 10% todennäköisyys saada keuhkosyöpä, kun taas tupakoimattomalla riski on noin 0,4%. Tupakoitsijan riski korkeassa radonpitoisuudessa (700 Bq/m3) on kaksinkertainen (2 * 10% eli 20%) ja tupakoimattoman samoin kaksinkertainen (eli 0,8%).

Tupakoitsijoilla radonista aiheu­tuva riski on siis absoluuttisesti suurempi kuin tupa­koimattomilla.

Unit

RR per Bq/m3

See also

References

  1. EnVIE final report. KTL, Kuopio, 2008. [1]
  2. IARC: Group 1 (Carcinogenic to humans): Radon-222 [10043-92-2] and its decay products (Vol. 43, Vol. 78; 2001)[2]
  3. United Nations Scientific Committee on the Effects of Atomic Radiation (UNSCEAR): 21 July 2009: There is mounting direct evidence to confirm a small but detectable risk of lung cancer from living with radon in the home [3]
  4. Darby S, Hill D, Auvinen A, Barros-Dios JM, Baysson H, Bochicchio F, Deo H, Falk R, Forastiere F, Hakama M, Heid I, Kreienbrock L, Kreutzer M, Lagarde F, Mäkeläinen I, Muirhead C, Obereigner W, Pershagen G, Ruano-Ravina A, Ruosteenoja E, Schaffrath-Rosario A, Tirmarche M, Tomasek L, Whitley E, Wichmann H-E, Doll R. Radon in homes and lung cancer risk: collaborative analysis of individual data from 13 European case-control studies. British Medical Journal 2005; 330: 223–226.[4]
  5. 5.0 5.1 Darby S, Hill D, Deo H, Auvinen A, Barros-Dios JM, Baysson H, Bochicchio F, Falk R, Farchi S, Figueiras A, Hakama M, Heid I, Hunter N, Kreienbrock L, Kreuzer M, Lagarde FC, Mäkeläinen I, Muirhead C, Oberaigner W, Pershagen G, Ruosteenoja E, Schaffrath Rosario A, Tirmarche M, Tomášek L, Whitley E, Wichmann H-E, Doll R. Residential radon and lung cancer – detailed results of a collaborative analysis of individual data on 7148 persons with lung cancer and 14 208 persons without lung cancer from 13 epidemiologic studies in Europe. Scandinavian Journal of Work, Environment Health 2006; 32 Suppl 1: 1–84.
  6. EnVIE final report. KTL, Kuopio, 2008. [5]

Related files

<mfanonymousfilelist></mfanonymousfilelist>