- The text on this page is taken from an equivalent page of the IEHIAS-project.
Parabens are chemicals used as preservatives in the cosmetics and pharmaceutical industry. Animal tests show weak oestrogenic activity
Parabens as biomarkers
Sample collection and storage
- Non-invasive matrices include urine and skin, with a high potential for hair as a matrix.
- Breast tissue is only available for the study of breast cancer cases.
Uptake of parabens mainly takes place through the skin
Urine and hair samples are taken and stored using routine methods
Generally, chemical analysis includes HPLC/MS or GC/MS methods
- Recovery estimates from the extraction procedure for breast cancer tissue gave an average recovery of around 50%.
- No information is available on inter- and intralaboratory variability.
No internationally recognized validation schemes
Because the major source of parabens is through cosmetics and pharmaceuticals, use patterns are extremely important factors
Concentrations reported in literature:
|Mean (SEM) ng/g (in breast cancer tissue)||0,0 (0,0)||0,9 (0,4)||2,3 (1,0)||2,6 (0,9)||2,0 (0,5)||12,8 (2,2)||20,6 (4,2)|
No clear dose-response relations are available for humans
Time trend, geographical variation, susceptibel groups:
No information is available