Changing ambient UVR and future skin cancer in London, Rome and Helsinki: melanoma skin cancer (CMM)
|Moderator:iranjon_95 (see all)|
|This page is a stub. You may improve it into a full page.|
- This case study was carried out as part (work package 3.7) of the EU-funded INTARESE project. The contents were obtained from IEHIAS toolbox.
It is widely accepted that ambient ultraviolet radiation (UVR) is carcinogenic (Lucas et al 2006) #: . The full references should be found on this page. --Jouni 06:59, 25 August 2011 (EEST) (type: truth; paradigms: science: relevant comment). This assessment will focus on the impact on malignant melanoma skin cancer (CMM). 
The international mechanism for protecting the ozone layer is the “Montreal Protocol on Substances That Deplete the Ozone Layer” that came into force in 1989 and its subsequent amendments (UNEP 2006). The production of the most harmful ozone depleting substances (ODS) are now phased out worldwide. The atmospheric concentrations of these gases is anticipated to decline over the next decades (IPCC 2005). As a result stratospheric ozone is expected to increase and, subsequently, ambient UVR is anticipated to decrease. Hence, a decrease in melanoma skin cancer is expected, but other factors may play an important role as well such as the ageing of the population.
We explore the effects of changing exposure to ambient ultraviolet radiation (UVR) on melanoma skin cancer, accounting for the recovery of the ozone layer due to decreasing emission of ODS and future emissions of CH4 and N20 (IPCC 2005). We also account for future demographic change
Scenario(s) and Type of Assessment
Type of assessment: prognostic.
UVR scenarios: IPCC (2000) SRES A2 and B1: future population & emissions/concentrations of ODS, CH4 and N2O.
SRES population scenarios were downscaled from the regional to the city-level.
|ODS Emission|| Decreasing trend
| Decreasing trend
same as A2
|CH4 Emission||Higher Increase||Lower Increase|
|N2O Emission||Higher Increase||Lower Increase|
|Population||Higher Growth||Lower growth|
|Age Structure||Slower Aging||Higher Aging|
Geographical and temporal scope:
Study area(s): City of Helsinki, Greater London, City of Rome
Populations: 5-year age groups up to 85+; males/females
Timeframe: 2001, 2030, 2050
Environmental and health factors:
Source: emissions of ODS (decreasing), N2O (increasing) and CH4 (increasing) ,affecting ozone fields
Environmental hazard: ambient UVR (erythemal dose).
Other risk factor: age.
Health outcomes: melanoma skin cancer (CMM) incidence/mortality (rates)
|Health authorities, policy/decision makers and health promotion agencies||Healthy population||Issue recommendations on solar exposure|
|Health care providers||Disease prevention, treatment||Treatment and advice particularly to groups at risk|
|Societies (cancer, osteoporosis, etc)||Support member interests||Issue public information|
|Advocacy groups||Protecting vulnerable groups||Reduce health impacts related to UVR.|
|Researchers||Research||Further knowledge of UVR-related health effects|
UVR exposure: UVR exposures are higher (and ozone recovery slower) in SRES-B1 compared to SRES-A2. The larger increase in ozone column in SRES-A2 can probably be explained by the higher abundance of CH4in this scenario. 
Health impact model 1 only accounts for future change in population size and structure, without accounting for future changes in incidence and mortality rates. The growing and ageing population results in a future increase in skin cancer incidence/mortality in both scenarios. As population growth is highest in SRES-A2, the total number of cases and deaths is also higher in this scenario compared to SRES-B1. For Helsinki and London, skin cancer incidence and mortality rates in the total population, however, are higher in the SRES-B1 scenario compared to the results for SRES-A2; this can be explained by the faster ageing of the population in SRES-B1.
Health impact model 2 also accounts for the future recovery of the ozone layer. The modelling shows a decrease in age-specific skin cancer incidence rates due to the recovery of the ozone layer. As expected, skin cancer incidence/mortality (rates) are lower in model 2 compared to model 1. The SRES-B1 scenario (i.e. the alternative with the lower recovery of the ozone layer) has somewhat higher UVR levels and, consequently, higher age-specific incidence rates than SRES-A2.
Similar conclusions for model 1 and model 2 can be drawn for the DALY calculations.
The sensitivity analyses shows that the choices regarding the PAF(high estimate is 0.9; low estimate is 0.5) had a large influence (circa 44%) on the health outcomes. Hence for policy purposes, it might be recommended to present all results using both the high and low PAF estimates. Applying age weights and discounting simultaneously to the DALY calculations decreased the number of DALY’s with more than 46%. The choice regarding the imr showed a relative large effect on the outcomes (25% decrease in DALYs compared to standard setting). The sensitivity analyses also shows that the additive effect of an 1°C increase in summer temperature (Van der Leun et al 2008) in 2030 (compared to baseline) could outweigh the effect of the decreasing UVR levels on age-specific incidence and mortality rates.
Modelled current and future exposure:
Based on modelled future percental change in exposure (SRES-A2 and SRES-B1 storylines and associated emission modelling). UVR exposures were calculated by applying ozone fields (estimated from SRES data on atmospheric concentrations of ODS, N2O and CH4) from the Oslo Chemical Transport Model (Rummukainen et al., 1999) complemented by atmospheric fields from the European Centre for Midrange Weather Forecasting (ECMWF). These model outcomes have been made available to INTARESE by Bjorg Rognerud, University of Oslo. These ozone fields were translated to ambient UVR assuming otherwise current atmospheric conditions. 
Health effect assessment
Exposure-response function (ERF)
The ERF is based on Scotto and Fears’ (1987) estimation of the biological amplification factor (BAF= relative change in disease risk due to a 10% increase in UVR exposure), adjusted for age.
|Face, head or neck (FHN), upper extremity (UE) *||Trunk & lower extremity (TL) **|
*higher risk estimate; standard model setting; ** lower risk estimate
Health effect modelling
- In the baseline model baseline incidence rates and baseline population estimates are applied.
- In model 1, baseline incidence rates and future population estimates are applied.
- In model 2, future incidence rates are calculated by applying the BAF and the future percental change in modelled ambient UVR to the baseline incidence rates. Results are combined with future population estimates.
Mortality (rates) (baseline/future) are calculated using the age-specific incidence:mortality ratios (imr), based on the incidence and morality rates in the EURA region as presented by Lucas et al (2006).
Attributable incidence and mortality are calculated using the upper estimate of population attributable fractions (PAF=0.9) as estimated by the WHO (Lucas et al. 2006).
Lung cancer cases in Europe due to indoor radon in residences (mean and 95% confidence interval).
|Health Model||Demographic Change||Decreasing Ambient UVR, due to Future Stratospheric Ozone Recovery|
* using baseline incidence rates per age group and gender.
* * Selected scenarios: SRES-B1 2030, SRES-B1 2050, SRES-A2 2030, SRES-A2 2050.
- Decreasing UVR levels result in lower age-specific incidence and mortality rates (model 1 versus model 2).
- For the population as a whole, this positive effect of decreasing ambient UVR is offset by increasing population size and further ageing of the population. Hence, policies to prevent or treat melanoma will still be relevant in the future, despite the recovery of the ozone layer.
- Based on the sensitivity analyses, it can be concluded that the positive effect of the recovery of the ozone layer could be outweighed by the possible additive effect of 1°C increase in summer temperature between 2000 and 2030, which is not very unlikely given the IPCC climate change scenarios (the national projections for Finland by Jylhä et al. (2004) indicated a temperature rise of 1-3˚C in 2010-2039 compared to 1960-1990).
- The inclusive full-chain model stimulated discussion about the risk assessment context. The exclusive framework stimulated discussion about excluded system factors.
- You often have to work with what is available. This facilitated discussion on choices/assumptions made, improving the (transparency of) the assessments. The sensitivity analyses explored the impact of varying relevant input assumptions, in order to determine how ‘sensitive’ a model is to changes in the value of the parameters of the model. Further discussion with stakeholder might add to this as well, but will be very time-consuming.
- One of the biggest challenges was the downscaling of the SRES-population scenarios from the OECD region to the city level (downscaling).
- There is no one-size fits all integrated assessment approach. General principles, methods and frameworks have to be made meaningful with the specific context of the case study. This requires: creativity, transparency, open attitude, and learning by doing.
- Our inventory of important literature, supporting materials and other useful (data) sources might be useful in future assessments.
#: . You have not copied the contents of the See also/References subpage. Put the Worked examples and Other data sources under the heading See also. Put the actual references into the body text by using ref tags. --Jouni 06:59, 25 August 2011 (EEST) (type: truth; paradigms: science: relevant attack)
Melanoma, ultraviolet radiation, climate change
- Maud Huynen et al. Changing ambient UVR and future skin cancer in London, Rome and Helsinki: melanoma skin cancer (CMM). INTARESE project, 2011.